Pyrophosphatases

A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.

Also Known As:

Networked: 171 relevant articles (5 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Doñate, Fernando: 4 articles (01/2018 - 04/2016)
2.	Morrison, Karen: 4 articles (01/2018 - 04/2016)
3.	Aidinis, Vassilis: 3 articles (01/2022 - 01/2020)
4.	Lagging, Martin: 3 articles (07/2021 - 06/2014)
5.	Aviña, Hector: 3 articles (01/2018 - 04/2016)
6.	Karki, Sher: 3 articles (01/2018 - 04/2016)
7.	Ou, Jimmy: 3 articles (01/2018 - 04/2016)
8.	Stover, David R: 3 articles (01/2018 - 04/2016)
9.	Maehara, Yoshihiko: 3 articles (01/2017 - 03/2012)
10.	Docampo, Roberto: 3 articles (09/2016 - 09/2005)

Related Diseases

1.	Anemia 03/07/2013 - "Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients." 10/01/2010 - "We identified a variant, located upstream of the inosine triphosphate pyrophosphatase gene on chromosome 20p13 that is significantly associated with treatment-induced anemia (combined P = 6.0 × 10(-14)). " 03/01/2015 - "The aim of this study was to clarify the association between the inosine triphosphate pyrophosphatase (ITPA) gene variants and PEG-IFNalpha/RBV combination treatment induced anemia in chronic hepatitis C (CHC) Ukrainian patients. " 12/01/2016 - "The most common adverse effect was anemia (hemoglobin <10 g/dL), especially for patients aged ≥ 65 with the inosine triphosphate pyrophosphatase CC genotype at rs1127354 (26.2%, 33/126). " 11/01/2013 - "Single nucleotide polymorphisms (SNPs) in the inosine triphosphate pyrophosphatase (ITPA) gene protect patients from ribavirin induced anemia. "
2.	Infections 01/01/1998 - "Studies of promoter fusion to a promoterless lacZ gene showed that compared to in vitro-grown bacteria, expression of the pyrophosphatase gene (ppa) was induced fourfold throughout the intracellular infection. " 01/01/2003 - "Our previous experiments have shown that InvA is an Ap5A pyrophosphatase, a member of the Nudix hydrolase family, which is up-regulated during the internalization, early growth phase, and exit steps during rickettsial mammalian cell infection. " 01/01/2016 - "We investigated the role of inosine triphosphate pyrophosphatase (ITPA) single nucleotide polymorphism (SNP) (rs1127354) in predicting RBV-induced anemia and thrombocytopenia among Egyptian patients with CHC genotype 4 infection. " 07/01/2021 - "Absence of a functional interferon-λ 4 (IFN-λ4) gene (IFNL4) predicts spontaneous resolution of acute hepatitis C virus (HCV) infections in regions with a predominance of genotype 1, whereas variants of the inosine triphosphate pyrophosphatase (ITPase) gene (ITPA) entailing reduced activity associate with increased sustained virologic response rates following some therapeutic regimens. " 06/01/2014 - "The present study evaluated the impact of variations in the inosine triphosphate pyrophosphatase (ITPase) gene (ITPA) on treatment outcome in patients with hepatitis C virus (HCV) genotype 2/3 infection receiving peginterferon-α2a and lower, conventional 800 mg daily dose of ribavirin. "
3.	Hepatitis C 03/01/2012 - "Efficacy of splenectomy in preventing anemia in patients with recurrent hepatitis C following liver transplantation is not dependent on inosine triphosphate pyrophosphatase genotype." 09/16/2015 - "Other investigations demonstrated that inosine triphosphate pyrophosphatase genetic variants protect hepatitis C virus-genotype-1 CHC patients from ribavirin-induced anemia, and other studies that a polymorphism in the patatin-like phospholipase domain-containing protein 3 was associated with hepatic steatosis in CHC patients. "
4.	Drug-Related Side Effects and Adverse Reactions 08/01/2012 - "Recent articles have reported that inosine triphosphate pyrophosphatase (ITPase) deficiency was associated with adverse drug reactions toward thiopurine drug therapy. " 07/01/2005 - "There is evidence that polymorphisms in the genes encoding thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPase) predict adverse drug reactions to AZA therapy. " 03/01/2004 - "Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)." 09/01/2007 - "In 422 consecutive patients (250 with Crohn's disease and 172 with ulcerative colitis) and 245 healthy controls, single nucleotide polymorphisms of thiopurine methyltransferase, inosine triphosphate pyrophosphatase and hypoxanthine phosphoribosyl transferase (HPRT1) genes were related to the occurrence of adverse drug reactions (ADRs) and efficacy of therapy. "
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/01/2009 - "Pro32Thr polymorphism of inosine triphosphate pyrophosphatase gene predicts efficacy of low-dose azathioprine for patients with systemic lupus erythematosus." 05/01/2010 - "Inosine triphosphate pyrophosphatase 94C>A polymorphism: clinical implications for patients with systemic lupus erythematosus treated with azathioprine." 05/01/2009 - "We evaluated the relationship between the efficacy of low-dose azathioprine (AZA) therapy and the inosine triphosphate pyrophosphatase (ITPA) 94C>A (Pro32Thr) polymorphism in patients with systemic lupus erythematosus (SLE). "

Related Drugs and Biologics

1.	Inosine Triphosphate (ITP)
2.	Inosine Triphosphatase
3.	thiopurine methyltransferase (thiopurine S-methyltransferase)
4.	Interferons
5.	Azathioprine (Imuran)
6.	Transferases
7.	Hypoxanthine
8.	Hydroxymethyl and Formyl Transferases
9.	Ribonucleotides
10.	Methotrexate (Mexate)

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Splenectomy
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Radiotherapy