|1.||Sowunmi, A: 10 articles (02/2007 - 04/2002)|
|2.||Adedeji, A A: 8 articles (02/2007 - 01/2004)|
|3.||Fateye, B A: 8 articles (02/2007 - 10/2003)|
|4.||Gbotosho, G O: 6 articles (02/2007 - 05/2004)|
|5.||Happi, T C: 6 articles (12/2006 - 01/2004)|
|6.||Doumbo, Ogobara K: 5 articles (01/2011 - 10/2006)|
|7.||Roper, Cally: 5 articles (01/2010 - 04/2003)|
|8.||Fehintola, F A: 5 articles (11/2005 - 01/2004)|
|9.||Yuthavong, Yongyuth: 4 articles (01/2013 - 11/2006)|
|10.||Kamchonwongpaisan, Sumalee: 4 articles (01/2013 - 11/2006)|
10/31/1959 - "[Clinical contribution to the determination of the efficacy of pyrimethamine in the prophylaxis and therapy of paludism]."
11/01/1999 - "Our study further suggests that pyrimethamine resistance can be monitored by a technique that can be adopted by malaria research centers in Africa."
12/01/1981 - "These in-vitro findings emphasize the importance of further studies into the toxicity of pyrimethamine when this drug is used for malaria prophylaxis in malnourished individuals."
01/01/2014 - "Intermittent preventive treatment of malaria in pregnancy (IPTp) using sulphurdoxine-pyrimethamine (SP) is one of key malaria control strategies in Africa. "
09/01/2013 - "Accessible mutational trajectories for the evolution of pyrimethamine resistance in the malaria parasite Plasmodium vivax."
|2.||Falciparum Malaria (Plasmodium falciparum Malaria)
01/01/2008 - "A random comparison of the efficacy of AQ (10 mg/kg/day x 3 d) and a single dose of SP (25 mg/kg of sulphadoxine/1.25 mg/kg of pyrimethamine) was performed in children under five years of age, with uncomplicated falciparum malaria, using the 28-day WHO therapeutic efficacy test. "
04/01/2006 - "Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia."
01/01/2009 - "Varying efficacy of artesunate+amodiaquine and artesunate+sulphadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in the Democratic Republic of Congo: a report of two in-vivo studies."
05/01/2004 - "Efficacy of sulfadoxin pyrimethamine for uncomplicated Plasmodium falciparum malaria in a small sample of Sudanese children."
12/01/2013 - "Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal."
01/01/2012 - "In conclusion, toxoplasmosis in heart allographs was more frequent among seronegative heart recipients, and oral pyrimethamine was highly effective for the prevention of T. "
02/01/2014 - "We propose an innovative product based on the nanoencapsulation of pyrimethamine (PYR), aiming an improvement of drug efficacy for the treatment of toxoplasmosis. "
11/01/1953 - "The chemotherapeutic efficacy of 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (daraprim) in experimental toxoplasmosis."
06/01/1998 - "Intention-to-treat vs. on-treatment analyses of clinical trial data: experience from a study of pyrimethamine in the primary prophylaxis of toxoplasmosis in HIV-infected patients. "
11/01/2014 - "Two inhibitors exhibited lower effective concentrations than the currently used toxoplasmosis drug pyrimethamine. "
09/01/1977 - "vivax, concomitant delivery of the two agents resulted in a 32-fold increase in the activity of pyrimethamine and a 50- to 100-fold increase in the activity of sulfadizine; 3) that as a result of this synergism, infections with the pyrimethamine resistant Ro/PM and Palo Alto strains could be cured with a fraction of the maximum tolerated dose of this drug; 4) that in marked contrast to the above result, infections with the Malayan Camp and Vietnam Smith strains of P. "
09/01/2005 - "Among patients infected with the quintuple resistant parasites, day 3 blood pyrimethamine concentrations were higher in those who cleared the infection than in those who did not (305 +/- 35.4 versus 228 +/- 21.7 ng/ml; P = 0.037). "
01/01/1993 - "Maternal weekly pyrimethamine prophylaxis did not appear to be effective in preventing infection as six (21.4%) of the 28 neonates whose mothers had regular prophylaxis had parasitaemia compared with seven (26.9%) of the 26 neonates whose mothers had no prophylaxis (chi 2 = 0.22; p > 0.05). "
11/01/1984 - "Urinary excretion studies indicated that protection persisted as long as the daily output of CGT did not fall below that attained with the parenterally administered hydrochloride salt at a dose equivalent to 0.015 mg of CGT per kg. Studies on infections with the resistant Ro/PM strain showed that the activity of CGT-P was compromised severely by resistance to pyrimethamine. "
01/01/1983 - "Further studies are indicated to determine to what extent findings obtained with the in vitro microtechnique can be correlated with the response of falciparum infection to treatment with pyrimethamine-sulphadoxine combinations."
|5.||Acquired Immunodeficiency Syndrome (AIDS)
10/01/1995 - "The authors report the use and the outcome of claritromycin associated with pyrimethamine in the treatment of toxoplasma encephalites in two patients with AIDS. "
08/01/1995 - "We have characterized the disposition of pyrimethamine in 20 adults with advanced AIDS. "
01/01/1992 - "Although the combination of pyrimethamine with a sulfonamide is still very effective for treatment of toxoplasmosis the use of these two drugs immunocompromised individuals, particularly AIDS patienst, often results in a remarkable incidence of adverse reactions. "
07/06/1996 - "[Efficacy of pyrimethamine in monotherapy for preventing toxoplasmosis in AIDS]."
01/01/1992 - "We retrospectively assessed the efficacy of maintenance therapy with pyrimethamine alone in 38 patients with AIDS and central nervous system (CNS) toxoplasmosis. "
|8.||Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
|1.||Drug Therapy (Chemotherapy)
|5.||Heart Transplantation (Grafting, Heart)