|1.||Kamei, Chiaki: 8 articles (01/2010 - 03/2002)|
|2.||Chen, Zhong: 5 articles (10/2014 - 09/2003)|
|3.||Tamaddonfard, Esmaeal: 4 articles (06/2015 - 07/2008)|
|4.||Fujii, Yoko: 4 articles (01/2007 - 03/2002)|
|5.||Farshid, Amir Abbas: 3 articles (06/2015 - 02/2010)|
|6.||Hu, Wei-Wei: 3 articles (08/2012 - 09/2003)|
|7.||Yanai, Kazuhiko: 3 articles (06/2011 - 09/2003)|
|8.||Hirasawa, Noriyasu: 3 articles (02/2011 - 10/2002)|
|9.||Ohuchi, Kazuo: 3 articles (02/2011 - 10/2002)|
|10.||Masuoka, Takayoshi: 3 articles (01/2010 - 03/2008)|
|1.||Anaphylaxis (Anaphylactic Shock)
01/01/1993 - "In conscious animals fasted overnight and then pretreated with mepyramine to prevent death due to acute bronchial anaphylaxis, exposure to nebulised allergen produced slight respiratory symptoms. "
01/01/1980 - "Large doses of pyrilamine maleate (/1-receptor antagonist) partially inhibited acute systemic anaphylaxis. "
09/01/1972 - "Effect of mepyramine and spasmolytic agents on guinea-pig anaphylaxis with special reference to the protracted shock."
12/01/1989 - "This inhibition of systemic LTC4 formation was associated with a complete protection against lethal anaphylactic shock in animals pretreated in addition with the H1 receptor antagonist pyrilamine. "
10/01/2001 - "Consequently, in conjunction the two experimental models used in this study--passive cutaneous anaphylactic reaction in guinea pigs and ex vivo [3H]-mepyramine binding to rat cortical membrane--may be important to estimate the duration of antiallergic effects of drugs and to detect their sedative effects, which are important indicators in the development of new antiallergic drugs."
01/01/1991 - "Compared to 0.3% pheniramine, 0.1% and 0.2% chlorpheniramine and 0.2% pyrilamine were statistically superior in inhibiting redness and itching. "
06/01/1994 - "This study investigated the effects of single doses of clemastine (2mg orally), mepyramine (2 micrograms intradermally) and placebo on weal and flare caused by intradermal chloroquine 2.5mg and histamine 2 micrograms in 11 healthy black subjects who experienced generalised pruritus with oral chloroquine. "
01/01/1991 - "The results of this study suggest that 0.1%, 0.2% and 0.3% chlorpheniramine, 0.3% dexbrompheniramine, 0.2% pyrilamine, and 0.4% and 0.5% pheniramine were effective in relieving the itching and conjunctival injection associated with topically applied histamine. "
02/01/1995 - "Thus PAF-induced ocular pruritus was unaffected by the histamine H1-receptor antagonist pyrilamine but was substantially attenuated by the PAF antagonists WEB 2086 and CV-6209 and was virtually abolished by E-6123. "
01/01/1991 - "0.3% chlorpheniramine, dexbrompheniramine, pyrilamine and pheniramine significantly reduced histamine-induced itching (p less than or equal to 0.01 for each drug) and conjunctival injection (p less than or equal to 0.02 for each drug), when compared to contralateral eyes receiving PBS. "
01/01/1984 - "Although histamine is implicated in the process of inflammation, the H1-antagonist, pyrilamine, had very little effect on ocular inflammation, whereas the H2-antagonist, cimetidine, exhibited no effect but rather enhanced the ocular inflammatory responses at the peak of inflammation. "
03/25/1983 - "Mepyramine maleate at a dose maximally effective on histamine-induced paw oedema (1 mg X kg-1 i.p.) failed to suppress carrageenan-induced inflammation. "
06/01/1982 - "Furthermore, combinations of cimetidine, mepyramine and indomethacin had only minor effects on the inflammation. "
03/11/1994 - "In a new model using conscious, unrestrained and ovalbumin-sensitized guinea pigs, we investigated the effects of the selective histamine H1 receptor antagonist, mepyramine, on the development of allergen-induced early and late asthmatic reactions, bronchial hyperreactivity and airway inflammation, having each animal as its own control. "
04/01/1961 - "Cortisone, mepyramine and sodium salicylate were effective in reducing histamine-induced inflammation, sodium salicylate being less active in the adrenalectomized animal. "
|4.||Memory Disorders (Memory Loss)
03/01/2008 - "We investigated the ameliorative effects of glutamatergic drugs on pyrilamine-induced spatial memory deficit and the decrease in hippocampal theta activity in rats. "
01/19/2007 - "Although the antagonistic effect of GBE on pyrilamine-induced spatial memory deficits was weak, a significant difference was observed with TE and WME. "
09/20/2002 - "Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. "
03/22/2002 - "On the other hand, pyrilamine caused a significant spatial memory deficit in control rats. "
01/01/2010 - "The working memory deficit and decreased hippocampal theta power induced by pyrilamine were ameliorated by intrahippocampal injection of (RS)-3,5-dihydroxyphenylglycine (DHPG) (1 and 10 microg/side), a group I mGlu-receptor agonist; however, intrahippocampal injection of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (APDC), a group II mGlu-receptor agonist, and L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), a group III mGlu-receptor agonist, showed no significant effect on the pyrilamine-induced memory deficit and decreased hippocampal theta activity. "
|5.||Body Weight (Weight, Body)
12/01/1975 - "Mepyramine does not significantly affect tolerance, and with regard to dependence there is an effect only on body weight loss, which is increased. "
10/01/1998 - "Values were determined without any treatment (baseline), after administration of pyrilamine maleate (1 mg/kg of body weight, i.v., given during a 15-minute period), and during 1-hour infusions of histamine at 3 rates (7.5, 15, and 30 microg/kg/h, i.v.). "
04/28/2000 - "Furthermore, the blockade of histamine H(1) receptors by mepyramine did not attenuate the effect of leptin on feeding and body weight. "
04/01/1983 - "At doses of 5 mg/kg body weight, the withanolide produced a moderate fall of blood pressure in dogs (34 +/- 2.1, mm Hg) which was blocked by atropine and not by mepyramine or propranolol. "
09/01/2000 - "Each experiment consisted of serial collection periods: baseline; infusion of pyrilamine maleate (1 mg/kg of body weight, IV); not treated; and IV infusion of saline (0.9% NaCl) solution alone, saline solution containing pentagastrin (6 microg/kg x h), or saline solution containing histamine (30 microg/kg x h). "
|1.||Histamine (Histamine Dihydrochloride)
|3.||Histamine H1 Receptors (Histamine H1 Receptor)
|7.||Pheniramine (Pheniramine Maleate)