|1.||Kwon, Youngjoo: 3 articles (07/2015 - 05/2010)|
|2.||Thapa, Pritam: 3 articles (07/2015 - 05/2010)|
|3.||Na, Younghwa: 3 articles (07/2015 - 05/2010)|
|4.||Lee, Eung-Seok: 3 articles (07/2015 - 05/2010)|
|5.||Karki, Radha: 2 articles (02/2012 - 05/2010)|
|6.||Cho, Won-Jea: 2 articles (02/2012 - 05/2010)|
|7.||Dempsey, Jack Alan: 2 articles (12/2004 - 01/2004)|
|8.||Keyser, Heather: 2 articles (12/2004 - 01/2004)|
|9.||Campbell, Robert M: 2 articles (12/2004 - 01/2004)|
|10.||Collins, Elizabeth: 2 articles (12/2004 - 01/2004)|
07/01/2015 - "A series of novel twenty-eight rigid 2-phenyl- or hydroxylated 2-phenyl-4-aryl-5H-indeno[1,2-b]pyridines were synthesized and evaluated for their topoisomerase inhibitory activity as well as their cytotoxicity against several human cancer cell lines. "
09/01/2012 - "Novel diamidino substituted conformationally restricted derivatives of bis-benzothiazolyl-pyridines and pyrazine were synthesized and their antiproliferative activity against several human cancer cell lines were determinated. "
07/03/2008 - "One of the resulting bicyclic and monocyclic (desilylated) pyridines was identified as an inhibitor of neuregulin-induced neurite outgrowth (EC(50) = 0.30 microM) in a screen that probes a pathway likely to be involved in breast cancers and schizophrenia."
09/01/2009 - "Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines."
08/18/2014 - "In this study we synthesized a series of imidazo[1,2-a]pyrimidines and imidazo[1,2-a]pyridines and identified some derivatives that were able to inhibit the Wnt/β-catenin signaling pathway in a luciferase reporter assay and cell proliferation in selected cancer cell lines, endowed with APC or β-catenin gene mutations. "
|2.||Central Nervous System Diseases (CNS Diseases)
06/05/2015 - "N-Bridged 5,6-bicyclic pyridines: Recent applications in central nervous system disorders."
09/01/2010 - "Four molecular descriptors were selected from a pool of variables using genetic algorithm, and then used to built a QSAR model for a series of 1-(azacyclyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT(6) receptor agonists or antagonists, useful for the treatment of central nervous system disorders. "
|3.||Breast Neoplasms (Breast Cancer)
08/01/2005 - "Effects of dihydropyridines and pyridines on multidrug resistance mediated by breast cancer resistance protein: in vitro and in vivo studies."
09/01/2002 - "The in vitro antitumor activities of 2,6-di-[2-(heteroaryl)vinyl]pyridines versus the standard National Cancer Institute 60 cell lines panel and of 2,6-di-[2-(heteroaryl)vinyl] pyridinium cations versus MCF7 (human mammary carcinoma) and LNCap (prostate carcinoma) cell lines are reported. "
08/01/2005 - "The effects of 25 synthesized dihydropyridines and corresponding pyridines along with 4 commercially available dihydropyridines (niguldipine, nicardipine, nifedipine, and nitrendipine) on the intracellular accumulation of the BCRP substrate mitoxantrone were evaluated in BCRP-expressing human breast cancer MCF-7/MX100 and human non-small cell lung cancer H460/MX20 cells. "
|5.||Dehydration (Water Stress)
02/11/2013 - "Spontaneous dehydration of the initially formed cycloadducts leads to the formation of a variety of substituted pyridines in moderate to good yields. "
01/01/2006 - "The approach led to the construction of N-substituted-1,2,3,4-tetrahydro[1,3]-dioxolo-[6,7]-5H-benzopyrano [3,4-c] pyridines ring systems involving the one-pot deprotection, cyclization and dehydration of N-substituted-4,4-ethylenedioxy-3- [(1,3-benzodioxol-5-yloxy)methyl]piperidines. "
04/12/2007 - "The unsaturated ketones and aldehydes derived from the cycloisomerization of primary and secondary propargyl diynols in the presence of [CpRu(CH3CN)3]PF6 (1) are converted to 1-azatrienes which in turn undergo a subsequent electrocyclization-dehydration to provide pyridines with excellent regiocontrol."
|1.||Protein Kinase Inhibitors
|2.||Protein Kinases (Protein Kinase)
|3.||Adenosine Triphosphate (ATP)
|4.||serotonin 6 receptor
|10.||Type I DNA Topoisomerases (Topoisomerase I)