|1.||Lau, Gee W: 5 articles (03/2012 - 11/2003)|
|2.||Winstanley, Craig: 4 articles (10/2015 - 01/2007)|
|3.||Hassett, Daniel J: 4 articles (12/2009 - 11/2003)|
|4.||Muller, Michael: 3 articles (05/2015 - 06/2009)|
|5.||Leto, Thomas L: 3 articles (02/2013 - 01/2009)|
|6.||Rada, Balázs: 3 articles (02/2013 - 01/2009)|
|7.||Fothergill, Joanne L: 3 articles (06/2011 - 01/2007)|
|8.||Taylor, Graham W: 3 articles (01/2008 - 02/2002)|
|9.||Whyte, Moira K B: 3 articles (01/2008 - 02/2002)|
|10.||Ran, Huimin: 3 articles (12/2004 - 11/2003)|
06/01/2014 - "In patients with hospital-acquired pneumonia, the expression of the Las and Rhl QS genes was associated with bacterial motility, biofilm formation, and pyocyanin production, suggesting an involvement of the QS genes in the clearance of pathogenic P. "
01/01/2015 - "Lung inflammation was induced using the culture supernatants from two Pseudomonas aeruginosa clinical strains, VR1 and VR2, isolated from patients affected by cystic fibrosis and showing different phenotypes in terms of motility, colony characteristics and biofilm production as well as pyoverdine and pyocyanine release. "
05/05/2015 - "These data suggest that GSH forms a cell-impermeant conjugate with pyocyanin and that availability of the thiol may be critical to minimizing the toxicity of this important bacterial virulence factor at infection sites. "
01/01/2014 - "These results imply that slow-growing clinical populations of lasR cells in chronic infections may contribute to virulence by producing pyocyanin under conditions where lasR⁺ cells do not."
02/01/2013 - "Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections."
09/01/2012 - "Pyocyanin is toxic to eukaryotic cells and has been shown to play a role in infection in a mouse model, making it an attractive target for anti-infective drug discovery. "
03/01/2011 - "Despite the long-appreciated in vivo role of the redox-active virulence factor pyocyanin in Pseudomonas airway infections and the importance of airway epithelial cells in combating bacterial pathogens, little is known about pyocyanin's effect on airway epithelial cells. "
|3.||Astrocytoma (Pilocytic Astrocytoma)
02/01/2012 - "In conclusion, this study provides the first evidence on mechanisms underlying the toxicity of both pyocyanin and 1-hydroxyphenazine to astrocytoma cells and provides novel evidence suggesting that this toxicity may be mediated by the formation of acidic vesicular organelles, a hallmark of autophagic cell death."
02/01/2012 - "Therefore, the aim of this study was to compare the CNS toxicity of pyocyanin and 1-hydroxyphenazine in vitro and to provide insight into mechanisms that underlie this toxicity using 1321N1 astrocytoma cells. "
05/01/2013 - "The role of autophagy in pyocyanin (PCN)-induced toxicity in the central nervous system (CNS) remains unclear, with only evidence from our group identifying it as a mechanism underlying toxicity in 1321N1 astrocytoma cells. "
02/01/2012 - "The autophagy inhibitor 3-methyladenine (5 mM) protected 1321N1 astrocytoma cells against both pyocyanin and 1-hydroxyphenazine-induced cell injury and increased accumulation of acidic vesicular organelles, a hallmark of autophagy. "
02/01/2012 - "Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity."
|5.||Cystic Fibrosis (Mucoviscidosis)
01/01/2007 - "Many isolates exhibit premature (during early rather than late exponential growth) and over-production of pyocyanin, which has a number of toxic effects directly relevant to cystic fibrosis. "
01/01/2007 - "Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain."
06/01/2004 - "Pyocyanin (1-hydroxy-N-methylphenazine) is a cytotoxic pigment secreted by the bacterial species Pseudomonas aeruginosa, which frequently infects the lungs of immunosuppressed patients as well as those with cystic fibrosis. "
02/15/2002 - "Pyocyanin-induced neutrophil apoptosis was not delayed either by treatment with LPS, a powerfully antiapoptotic bacterial product, or in neutrophils from cystic fibrosis patients. "
02/01/2014 - "The blue-green phenazine, Pyocyanin (PYO), is a well-known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. "
|2.||Sulfhydryl Compounds (Thiols)
|3.||Heme Oxygenase (Decyclizing) (Heme Oxygenase)
|5.||Pancreatic Elastase (Elastase)
|6.||Pregnenolone Carbonitrile (PCN)
|8.||Virulence Factors (Pathogenicity Factors)
|9.||Interleukin-8 (Interleukin 8)