Thrombocytopenic Purpura (Thrombopenic Purpura)

Subscribe to Selected New Research on Thrombocytopenic Purpura

1470 relevant articles (75 outcomes, 84 trials/studies) found for this Disease

Description: Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.

Also Known As:

Thrombopenic Purpura; Purpura, Thrombocytopenic; Purpuras, Thrombocytopenic; Purpuras, Thrombopenic; Thrombocytopenic Purpuras; Thrombopenic Purpuras; Purpura, Thrombopenic

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases

Hematologic Diseases: 1421

Blood Coagulation Disorders: 86

Purpura: 1855

Thrombocytopenic Purpura: 1470

Idiopathic Thrombocytopenic Purpura: 2748

Thrombotic Thrombocytopenic Purpura: 1663

Wiskott-Aldrich Syndrome: 356

Blood Platelet Disorders: 77

Thrombocytopenia: 12251

Thrombocytopenic Purpura: 1470

Idiopathic Thrombocytopenic Purpura: 2748

Thrombotic Thrombocytopenic Purpura: 1663

Wiskott-Aldrich Syndrome: 356

Immune System Diseases: 1237

Thrombocytopenic Purpura: 1470

Idiopathic Thrombocytopenic Purpura: 2748

Related Diseases

1.	Thrombocytopenia (Thrombopenia)
2.	Infection
3.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
4.	Rheumatoid Arthritis
5.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)

Experts

1.	Bussel, James B: 12 articles (01/2008 - 03/2002)
2.	Tarantino, Michael D: 6 articles (06/2007 - 06/2003)
3.	Vianelli, Nicola: 4 articles (09/2008 - 01/2005)
4.	George, James N: 4 articles (01/2008 - 06/2003)
5.	McMillan, Robert: 4 articles (01/2008 - 09/2002)
6.	Buchanan, George R: 4 articles (05/2007 - 02/2004)
7.	McMillan, R: 4 articles (03/2003 - 07/2000)
8.	Sandler, S G: 4 articles (11/2001 - 03/2000)
9.	Bussel, J B: 4 articles (05/2001 - 01/2000)
10.	Baccarani, Michele: 3 articles (09/2008 - 07/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thrombocytopenic Purpura:

1.	Inosine Triphosphate (ITP)IBA 01/01/1992 - "In one case, remission of AIHA allowed the donor's PBMC to successfully reconstitute SCID mice, despite the fact that the donor had developed immune thrombocytopenic purpura (ITP)" 02/01/2007 - "Immune thrombocytopenic purpura diagnosed in adolescence is more likely to be chronic then in childhood ITP, but has a higher rate of spontaneous resolution than in adults" 12/01/2006 - "Recurrent immune thrombocytopenic purpura (ITP) is defined as the recurrence of ITP after at least 3 months of remission sustained without treatment" 10/06/2008 - "OBJECTIVE: To determine whether Helicobacter pylori eradication is an effective treatment for Australian patients with chronic immune thrombocytopenic purpura (ITP)" 08/01/2008 - "BACKGROUND: Corticosteroid (CS) therapy is effective in many patients with immune thrombocytopenic purpura (ITP), although it is associated with adverse effects" Order ALL the reference details at left...
2.	rituximab (Mabthera)FDA Link 06/01/2006 - "Rituximab in the management of chronic immune thrombocytopenic purpura: an effective and safe therapeutic alternative in refractory patients." 08/01/2004 - "Rituximab is effective for selected patients with chronic steroid-refractory immune thrombocytopenic purpura." 01/01/2006 - "Rituximab appears to constitute a safe and effective treatment for refractory immune thrombocytopenic purpura associated with SLE in patients having a contraindication to or refractory to conventional therapy." 02/01/2005 - "CONCLUSIONS: Rituximab may be a useful treatment for chronic immune thrombocytopenic purpura in children with a >50% CR rate lasting an average of 13 months, with 9 of 15 CRs ongoing (8 lasted 6 months or longer)" 11/01/2005 - "Long-term cost-efficacy of rituximab in immune thrombocytopenic purpura." Order ALL the reference details at left...
3.	Intravenous Immunoglobulins (IVIG)FDA Link 07/01/2005 - "Then it has been shown to be effective in the treatment of patients with thrombocytopenic purpura, and in the last decade, IVIG has been used in the treatment of many autoimmune and systemic inflammatory diseases" 03/01/1999 - "The influence of Epstein-Barr virus seropositivity on the efficacy of intravenous immune globulin in children with immune thrombocytopenic purpura." 05/01/1997 - "Safety and efficacy of low-dose intravenous immune globulin (IVIG) treatment for infants and children with immune thrombocytopenic purpura" 01/01/2007 - "Our study showed that IVIG blocked IFN-gamma signaling and IFN-gamma-induced gene expression and suppressed IFN-gamma function in vivo during immune responses to Listeria monocytogenes and in an IFN-gamma-enhanced model of immune thrombocytopenic purpura" 01/01/1985 - "A multicenter European trial of intravenous immune globulin in immune thrombocytopenic purpura in childhood." Order ALL the reference details at left...
4.	Immunoglobulin G (IgG)IBA 09/01/1995 - "Platelet associated IgG in chronic relapsing thrombocytopenic purpura in remission." 09/01/1984 - "Studies of platelet-associated IgG and in vivo platelet survival demonstrated immune-mediated destruction of platelets consistent with immune thrombocytopenic purpura" 03/01/2005 - "Evidence suggests that amelioration of childhood immune thrombocytopenic purpura and some other autoimmune states by intravenous normal IgG is due to the following chain of events: (1) cross-linking of Fcgamma-receptors on blood effector cells; (2) release of mediators from these cells, often yielding an infusion-related reaction; (3) mediator-induced development of a cytokine field characterized by a mutually stabilizing Th2 polarization of CD4 T lymphocytes and alternative activation of macrophages; (4) selective quiescence of these macrophages towards targets coated with IgG autoantibody, due to increased expression of the macrophage Fcgamma-receptor IIB" 11/01/1999 - "Corticosteroid prophylaxis for neurologic complications of intravenous immunoglobulin G therapy in childhood immune thrombocytopenic purpura." 02/01/1997 - "Neurologic complications of treatment of childhood acute immune thrombocytopenic purpura with intravenously administered immunoglobulin G." Order ALL the reference details at left...
5.	Immunoglobulins (Immunoglobulin)IBA 12/01/2005 - "In this preliminary study, the value of different platelet parameters, measured by the ADVIA120 Analyzer, in predicting the immediate response to intravenous immunoglobulin or intravenous anti-RhoD was assessed in 31 patients with immune thrombocytopenic purpura" 10/01/2003 - "Low-dose versus high-dose immunoglobulin for primary treatment of acute immune thrombocytopenic purpura in children: results of a prospective, randomized single-center trial." 01/01/2003 - "Efficacy, tolerability, safety and pharmacokinetics of a nanofiltered intravenous immunoglobulin: studies in patients with immune thrombocytopenic purpura and primary immunodeficiencies." 01/01/2008 - "Weekly long-term intravenous immunoglobulin for refractory parvovirus B19 and Epstein-Barr virus-induced immune thrombocytopenic purpura." 03/01/2007 - "Safety and tolerability of a novel chromatography-based intravenous immunoglobulin when administered at a high infusion rate in patients with immune thrombocytopenic purpura." Order ALL the reference details at left...
6.	Danazol (Azol)FDA LinkGeneric 12/01/1988 - "Danazol seems to be effective in the treatment of children with immune thrombocytopenic purpura and would warrant additional studies to determine its proper role in the management of this common pediatric ailment." 09/01/1985 - "The use of danazol in the management of chronic immune thrombocytopenic purpura." 03/01/1999 - "Danazol therapy in cyclic acquired amegakaryocytic thrombocytopenic purpura: a case report." 08/01/1995 - "Thrombocytopenic purpura following treatment with danazol." 07/01/1995 - "Treatment of idiopathic thrombopenic purpura with danazol]" Order ALL the reference details at left...
7.	RHO(D) antibody (anti-D)IBA 01/01/2007 - "Immune thrombocytopenic purpura associated with renal disease is usually therapy-related, occurring after administration of intravenous immunoglobulin therapy or anti-D" 11/01/2003 - "Use of intravenous anti-D in patients with refractory and relapsed immune thrombocytopenic purpura." 11/01/2003 - "Initial management of immune thrombocytopenic purpura in adults: a randomized controlled trial comparing intermittent anti-D with routine care." 03/01/2001 - "A dose of 75 microg/kg/d of i.v. anti-D increases the platelet count more rapidly and for a longer period of time than 50 microg/kg/d in adults with immune thrombocytopenic purpura." 01/01/1999 - "Treatment of childhood acute immune thrombocytopenic purpura with anti-D immune globulin or pooled immune globulin." Order ALL the reference details at left...
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/1982 - "Remission of post-transfusion thrombocytopenic purpura with high dose intravenous corticosteroids." 09/06/2004 - "The immune thrombocytopenic purpura was successfully treated with anti-tuberculous drugs combined with corticosteroids and high dose immune globulin therapy" 10/01/1993 - "Intravenous corticosteroids versus intravenous gammaglobulin in the treatment of acute immune thrombocytopenic purpura." 01/01/1973 - "The place corticosteroids in the treatment of idiopathic thrombopenic purpura]" 01/01/1986 - "Efficacy of the injection of corticoids combined with plasma exchange in the treatment of patients with autoimmune thrombopenic purpura]" Order ALL the reference details at left...
9.	AutoantibodiesIBA 10/01/1989 - "Immunochemical analysis of platelet autoantibodies in HIV-related thrombocytopenic purpura: a study of 68 patients." 09/01/1998 - "Platelet autoantibodies in immune thrombocytopenic purpura." 12/01/1996 - "Autoantibodies in chronic immune thrombocytopenic purpura occasionally interfere with platelet function" 06/01/1995 - "Autoantibodies and CD5+ B cells in childhood onset immune thrombocytopenic purpura." 01/01/1993 - "Kami-kihi-to appears to promote the suppression of autoantibodies in patients with chronic immune thrombocytopenic purpura" Order ALL the reference details at left...
10.	AntibodiesIBA 01/01/1982 - "Studies of platelet antibodies in patients with thrombocytopenic purpura by two different techniques." 02/01/2007 - "Unappreciated HLA antibodies in adult immune thrombocytopenic purpura." 07/01/2005 - "All auto-immune thrombocytopenic purpura (AITP) patients had serologic assessment for associated auto-antibodies at the time of inclusion" 01/01/2005 - "Antiplatelet antibodies and their correlation with clinical findings in childhood immune thrombocytopenic purpura." 01/01/2001 - "Anti-alphavbeta3 antibodies in chronic immune thrombocytopenic purpura." Order ALL the reference details at left...

Therapies and Procedures

1.	Splenectomy 03/01/1993 - "Splenectomy is a safe and effective treatment in HIV-infected patients with severe symptomatic thrombocytopenic purpura resistant to medical therapy." 10/01/1991 - "The site of platelet destruction in thrombocytopenic purpura as a predictive index of the efficacy of splenectomy." 02/01/1986 - "In six patients with thrombocytopenic purpura not cured by splenectomy platelets fell to less than 150 X 10(9)/l within six weeks of splenectomy" 08/01/2006 - "Predictive factors for successful laparoscopic splenectomy in immune thrombocytopenic purpura: study of clinical and laboratory data." 01/01/1977 - "After a critical study, a splenectomy was performed in a 6-year-old boy with chronic thrombocytopenic purpura" Order ALL the reference details at left...
2.	Platelet Transfusion (Blood Platelet Transfusions) 03/01/1991 - "Intravascular platelet transfusion in utero for the treatment of immunologic thrombocytopenic purpura: a case report]" 03/01/1987 - "Thrombocytopenic purpura and platelet transfusion." 10/18/1976 - "Platelet transfusion in immune thrombocytopenic purpura." 01/30/1969 - "Use of "compatible" platelet transfusions in treatment of congenital isoimmune thrombocytopenic purpura." 08/01/1994 - "Refractory immune thrombocytopenic purpura accompanied with avascular necrosis of femoral head receiving the combination of high dose immunoglobulin therapy followed by platelet transfusion could successfully be managed to undergo surgery]" Order ALL the reference details at left...
3.	Plasma Exchange 10/01/2005 - "Plasma exchanges as treatment of severe acute immune thrombocytopenic purpura]" 09/01/1998 - "The Canadian experience using plasma exchange for immune thrombocytopenic purpura" 01/01/1988 - "Combined plasma exchange and intravenous gammaglobulin in the treatment of patients with refractory immune thrombocytopenic purpura." 02/28/1981 - "Value of plasma exchange in the management of acute immunoallergic thrombocytopenic purpura (author's transl)]" 02/01/2000 - "Thrombocytopenic purpura resolved 2 months after discontinuation of plasma exchange while the patient received chemotherapy" Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 12/01/2004 - "This article discusses the pros and cons of drug therapy for immune thrombocytopenic purpura in children." 12/01/2004 - "The pros and cons of drug therapy for immune thrombocytopenic purpura in children." 02/01/2004 - "The child with immune thrombocytopenic purpura: is pharmacotherapy or watchful waiting the best initial management" 02/01/2000 - "Thrombocytopenic purpura resolved 2 months after discontinuation of plasma exchange while the patient received chemotherapy" 01/01/2006 - "CASE REPORT: A newly diagnosed patient with metastatic pancreatic adenocarcinoma developed thrombocytopenic purpura prior to initiation of chemotherapy" Order ALL the reference details at left...
5.	Colectomy 12/01/2003 - "We report a case with ulcerative colitis and immune thrombocytopenic purpura which were cured after the colectomy" 12/01/2003 - "Resolution of immune thrombocytopenic purpura after colectomy for ulcerative colitis." 11/01/2001 - "Complete resolution of refractory immune thrombocytopenic purpura after colectomy for ulcerative colitis." 11/01/1999 - "Can colectomy cure immune thrombocytopenic purpura in a patient with ulcerative colitis?" Order ALL the reference details at left...

Best Treatments:
Research Summary Report
on Thrombocytopenic Purpura