Schoenlein-Henoch Purpura (Purpura, Schoenlein Henoch)

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511 relevant articles (13 outcomes, 19 trials/studies) found for this Disease

Description: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.

Also Known As:

Purpura, Schoenlein Henoch; Anaphylactoid Purpura; Nonthrombocytopenic Purpura; Allergic Purpura; Henoch Purpura; Purpura, Schoenlein-Henoch; Purpura, Nonthrombopenic; Fulminans, Purpura; Hemorrhagic Vasculitis; Hemorrhagica, Purpura; Henoch Schoenlein Purpura; Nonthrombopenic Purpura; Nonthrombopenic Purpuras; Purpura, Allergic; Purpura, Anaphylactoid; Purpura, Henoch; Purpura, Henoch-Schoenlein; Purpura, Rheumatoid; Purpuras, Nonthrombopenic; Schoenlein Henoch Purpura; Henoch-Schoenlein Purpura; Purpura Fulminans; Purpura Hemorrhagica; Purpura, Nonthrombocytopenic; Rheumatoid Purpura; Vasculitis, Hemorrhagic

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18525

Vascular Diseases: 7184

Vasculitis: 6337

Hypersensitivity Vasculitis: 378

Schoenlein-Henoch Purpura: 511

Hemic and Lymphatic Diseases

Hematologic Diseases: 1421

Hemorrhagic Disorders: 447

Hemostatic Disorders: 99

Schoenlein-Henoch Purpura: 511

Blood Coagulation Disorders: 86

Purpura: 1855

Schoenlein-Henoch Purpura: 511

Immune System Diseases: 1237

Hypersensitivity: 36030

Immune Complex Diseases: 341

Hypersensitivity Vasculitis: 378

Schoenlein-Henoch Purpura: 511

Related Diseases

1.	Nephritis
2.	Sepsis (Septicemia)
3.	Nephrotic Syndrome (Syndrome, Nephrotic)
4.	Septic Shock (Toxic Shock Syndrome)
5.	Syndrome

Experts

1.	Lee, Jae Seung: 2 articles (11/2007 - 06/2007)
2.	Shin, Jae Il: 2 articles (11/2007 - 06/2007)
3.	Sadik, Ahmed: 2 articles (04/2007 - 07/2003)
4.	Leclerc, Francis: 2 articles (04/2007 - 07/2003)
5.	Suzuki, Hitoshi: 2 articles (03/2007 - 01/2007)
6.	Farrell, Mary M: 2 articles (05/2006 - 07/2005)
7.	Tilelli, John Arthur: 2 articles (05/2006 - 07/2005)
8.	Sarwari, Arif R: 1 article (10/2008)
9.	Minhas, Khalid M: 1 article (10/2008)
10.	Bashir, Shahida: 1 article (10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Schoenlein-Henoch Purpura:

1.	Protein CIBA 05/01/2006 - "BACKGROUND AND OBJECTIVES: The aim of this study was to document the effects of supplementation with a plasma-derived protein C concentrate in adult patients with infectious purpura fulminans" 05/01/2004 - "CONCLUSIONS: Treatment with protein C concentrate is followed by an improvement of the coagulopathy and is safe in children with purpura fulminans; however, a large trial involving a high dose is required to determine its effect on mortality and morbidity" 07/01/2003 - "Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: a pharmacokinetic study." 12/01/2000 - "An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia." 10/01/2008 - "Pneumococcal purpura fulminans successfully treated with activated protein C." Order ALL the reference details at left...
2.	Antithrombin IIIIBA 10/01/1994 - "Meningococcal purpura fulminans treated with antithrombin III concentrate: what is the optimal replacement therapy?" 12/01/2002 - "Significant advances have been made in understanding the physiopathology of the meningococcal purpura fulminans especially about the deleterious role of the deficiency of the protein C and the antithrombin III. It is too soon to advance that the prognosis of these diseases has been improved by these new therapeutic approaches but the results of preliminary clinical studies are encouraging" 01/01/1990 - "Meningococcemia and purpura fulminans in adults: acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates." 12/01/1997 - "Personal experience is reported on the efficacy of heparin in combination with antithrombin III in the treatment of purpura fulminans in two preterm neonates who did not have inherited deficiency of protein C or S and developed the disease possibly following prolonged labor (36 hours) in the first case, and maternal neoplasia, in the second" 01/01/2008 - "First, neonatal purpura fulminans is associated with a hereditary deficiency of the natural anticoagulants Protein C and Protein S as well as Antithrombin III. Idiopathic purpura fulminans usually follows an initiating febrile illness that manifests with rapidly progressive purpura" Order ALL the reference details at left...
3.	Methylprednisolone FDA LinkGeneric 01/01/2007 - "Complete remission of nephrotic syndrome with methylprednisolone pulses in an adult with Schönlein-Henoch purpura]" 04/01/1998 - "Between 1980 and 1994, 38 children with severe forms of Schönlein-Henoch purpura glomerulonephritis were entered into a prospective study to evaluate methylprednisolone pulse therapy on the outcome of nephropathy in terms of clinical symptoms and histopathological changes" 04/01/1998 - "Methylprednisolone pulse therapy in the treatment of severe forms of Schönlein-Henoch purpura nephritis." 09/01/1995 - "Successful treatment of rapidly progressive glomerulonephritis associated with Henoch-Schoenlein purpura with high doses of methylprednisolone]" 03/01/2007 - "Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis." Order ALL the reference details at left...
4.	drotrecogin alfa activated (Xigris)FDA Link 02/01/2003 - "Drotrecogin alfa (activated) for the treatment of meningococcal purpura fulminans." 08/01/2005 - "INTRODUCTION: We report data from adult and pediatric patients with severe sepsis from studies evaluating drotrecogin alfa (activated) (DrotAA) and presenting with purpura fulminans (PF), meningitis (MEN), or meningococcal disease (MD) (PF/MEN/MD)" 08/01/2005 - "Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies." 05/01/2005 - "Treatment with protein C concentrate or recombinant activated protein C (Drotrecogin alfa, activated) has been shown to be beneficial in sepsis-induced purpura fulminans" 02/01/2004 - "Based on case reports, treatment with drotrecogin alfa (activated) or substitution of protein C have been recommended for adjuvant treatment of sepsis-related purpura fulminans." Order ALL the reference details at left...
5.	Heparin (Liquaemin)FDA LinkGeneric 05/01/1996 - "The potentials of heparin monotherapy in patients with hemorrhagic vasculitis and kidney involvement]" 11/01/1987 - "The autocoagulation test and heparin therapy of patients with hemorrhagic vasculitis]" 01/01/1986 - "Eighty eight children with extrarenal manifestations of Henoch-Schoenlein purpura received 120-150 IU/kg heparin in infusion for three days at onset and at relapses" 08/01/1979 - "Results of the heparin treatment of children with hemorrhagic vasculitis]" 08/01/1970 - "Value of heparin in the treatment of meningococcal purpura fulminans" Order ALL the reference details at left...
6.	CortisoneIBA 12/01/1959 - "Purpura fulminans and cortisone.]" 02/19/1954 - "Therapy of Schoenlein-Henoch purpura with cortisone.]" 10/01/1953 - "Rheumatoid purpura treated with cortisone.]" 09/19/1953 - "A.C.T.H and cortisone in idiopathic thrombocytopenic and Schönlein-Henoch (allergic) purpura." 11/01/1951 - "Cortisone in allergic purpura of children." Order ALL the reference details at left...
7.	SteroidsIBA 05/01/2000 - "Steroids for prophylaxis of nephropathy in Schnlein Henoch purpura" 09/01/1993 - "Anaphylactoid purpura and renal disease: the case against routine steroids." 01/01/1988 - "Incidence of renal complications in Schönlein-Henoch purpura syndrome in dependence of an early administration of steroids." 09/01/1987 - "Can the nephropathy in Schönlein-Henoch purpura (syndrome) be prevented by early administration of steroids?" 01/01/1952 - "Excretion of cortical steroids and allergic reaction in a case of rheumatoid purpura.]" Order ALL the reference details at left...
8.	Cyclosporine (Ciclosporin)FDA LinkGeneric 06/01/1998 - "Failure of cyclosporine A in controlling Schoenlein-Henoch purpura." 04/01/1997 - "Severe nephrotic syndrome in a patient with Schönlein-Henoch purpura: complete remission after cyclosporin A." Order ALL the reference details at left...
9.	Ketoconazole (Nizoral)FDA LinkGeneric 11/01/2007 - "Although it may be prudent to provide stress-dose steroids to children with septic shock who are clinically at risk for adrenal insufficiency (chronic or recent steroid use, purpura fulminans, etomidate or ketoconazole administration, hypothalamic, pituitary, adrenal disease), the safety and efficacy of stress-dose steroids as general adjunctive therapy for pediatric septic shock have not been established" Order ALL the reference details at left...
10.	Etomidate FDA LinkGeneric 11/01/2007 - "Although it may be prudent to provide stress-dose steroids to children with septic shock who are clinically at risk for adrenal insufficiency (chronic or recent steroid use, purpura fulminans, etomidate or ketoconazole administration, hypothalamic, pituitary, adrenal disease), the safety and efficacy of stress-dose steroids as general adjunctive therapy for pediatric septic shock have not been established" Order ALL the reference details at left...

Therapies and Procedures

1.	Plasma Exchange 01/01/1979 - "Plasma exchange as sole therapy was effective in patients with idiopathic anaphylactoid purpura and mixed cryoglobulinaemia, but not in one SLE patient with CIC" 03/01/1987 - "Treatment, by plasma exchange, of a severe digestive manifestation of rheumatoid purpura in an adult]" 04/28/1982 - "Plasma exchange treatment in a patient with severe Schoenlein-Henoch purpura]" 01/01/2004 - "These findings suggested that plasma exchange was effective in leading remission in a case of allergic purpura nephritis associated with thrombotic microangiopathy." 01/01/2004 - "Successful treatment of allergic purpura nephritis associated with thrombotic microangiopathy using plasma exchange: a case report]" Order ALL the reference details at left...
2.	Plasmapheresis 09/01/1989 - "Experience in the use of plasmapheresis in children with hemorrhagic vasculitis]" 03/01/2004 - "Successful treatment of crescentic glomerulonephritis associated with adult-onset Henoch-Schoenlein purpura by double-filtration plasmapheresis." 09/01/1981 - "Two adult patients with Henoch-Schoenlein purpura and rapidly progressive glomerulonephritis were treated with plasmapheresis" 01/01/1988 - "In virus hepatitis with liver insufficiency, bullous erythema and hemorrhagic vasculitis plasmapheresis can be used as an independent method" 01/01/1984 - "The authors discuss the results of the use of therapeutic plasmapheresis (290 sessions) in 56 patients with immunity-mediated diseases: hemorrhagic vasculitis, Goodpasture's syndrome, multiple sclerosis, Guillain-Barre's syndrome, rheumatoid arthritis, partial red cell aplasia, etc. Demonstrate the possibilities of the attainment of positive results provided plasmapheresis is included into the complex of therapeutic measures" Order ALL the reference details at left...
3.	Tonsillectomy 03/01/2002 - "OBJECTIVE: To explore the peri-operative cure of patients suffered allergic purpura before tonsillectomy" 03/01/2002 - "The peri-operative cure of patients suffered allergic purpura before tonsillectomy]" 03/01/2007 - "Efficacy of tonsillectomy plus methylprednisolone pulse therapy for a child with Henoch-Schoenlein purpura nephritis." Order ALL the reference details at left...
4.	Hyperbaric Oxygenation 09/01/2000 - "OTHER STRATEGIES: Improvement in limb perfusion was achieved after hyperbaric oxygenation in patients with purpura fulminans caused by different pathogens" Order ALL the reference details at left...
5.	Amputation 09/01/2006 - "The authors report a case of nasal reconstruction in a 5-year-old boy who had undergone subtotal amputation of the nose 8 months before in the context of meningococcus-induced purpura fulminans" 09/01/2006 - "Suitable age for nasal reconstruction after subtotal amputation in a child, with respect to a case involving purpura fulminans." 04/01/2003 - "CONCLUSIONS: The data would suggest that children requiring surgery for purpura fulminans achieve age-appropriate milestones and are primarily limited by their physical disability related to amputations, scarring, and abnormal bone growth." 01/01/2002 - "In a third case, secondary reconstructive measures had to be performed 1 year after purpura fulminans due to insufficient soft-tissue coverage after lower leg amputation" 06/01/2001 - "We used this method in seven patients (five men, two women; mean age 30 years) who had had below-knee amputations, six of them after injury to a healthy limb and one for purpura fulminans" Order ALL the reference details at left...

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