Purine-Nucleoside Phosphorylase

An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free purine plus ribose-5-phosphate. EC 2.4.2.1.

Also Known As:

Nicotinamide Riboside Phosphorylase; Purine Nucleoside Phosphorylases; Nucleoside Phosphorylases, Purine; Phosphorylase, Inosine; Phosphorylase, Nicotinamide Riboside; Phosphorylase, Purine-Nucleoside; Phosphorylases, Purine Nucleoside; Purine Nucleoside Phosphorylase; Riboside Phosphorylase, Nicotinamide; Inosine Phosphorylase; Purine-nucleoside:orthophosphate ribosyltransferase

Networked: 319 relevant articles (6 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Pentosyltransferases
        Purine-Nucleoside Phosphorylase: 319
        5'-methylthioadenosine phosphorylase: 183
        Purine Nucleoside Phosphorylase Deficiency: 159
        adenosine phosphorylase: 2
        Arabidopsis MTAN1 protein
        Arabidopsis MTAN2 protein
        Immune Defect Due To Inosine Phosphorylase Deficiency
        xanthosine phosphorylase

Experts

1.	Parker, William B: 11 articles (01/2020 - 01/2003)
2.	Sorscher, Eric J: 10 articles (01/2020 - 01/2003)
3.	Grunebaum, Eyal: 8 articles (11/2018 - 03/2004)
4.	Gandhi, Varsha: 8 articles (01/2017 - 12/2005)
5.	Allan, Paula W: 7 articles (01/2020 - 01/2003)
6.	Schramm, Vern L: 7 articles (01/2018 - 12/2008)
7.	Waud, William R: 6 articles (01/2020 - 01/2003)
8.	Roifman, Chaim M: 6 articles (08/2012 - 04/2003)
9.	Secrist, John A: 5 articles (01/2020 - 01/2003)
10.	Bantia, Shanta: 5 articles (08/2013 - 06/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. " 11/08/2017 - "coli Purine Nucleoside Phosphorylase in the Treatment of Solid Tumors." 01/01/2016 - "coli purine nucleoside phosphorylase (PNP) gene was originally described by our laboratories as a means to inhibit growth of solid tumors in vivo. " 12/01/2011 - "However, novel suicide genes, such as Escherichia coli purine nucleoside phosphorylase (PNP), have been utilized to demonstrate more potent tumor killing and an enhanced bystander effect on local, non-expressing cells compared to HSV-tk. " 06/08/2008 - "coli) purine nucleoside phosphorylase (PNP)/9-(2-deoxy-beta-dribofuranosyl)-6-methylpurine (MeP-dR) suicide gene system exhibits excellent anti-tumor effects, indicating this system directed by a HCC-specific promoter would offer a possibility of targeting gene therapy for HCC. "
2.	Urinary Bladder Neoplasms (Bladder Cancer) 03/01/2007 - "The purpose of this study was to evaluate the in vivo transduction efficiency and the therapeutic efficacy of the RCR vector mediated delivery of Escherichia coli purine nucleoside phosphorylase (PNP) in combination with fludarabine phosphate for bladder cancer. " 03/01/2007 - "Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts." 10/01/1984 - "In ACI/N rats pretreated with cyclophosphamide (CY) growth of the bladder cancer, BC-47, and adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) activities in lymphocytes were investigated to clarify the possible antitumor effect via the immune system of the chemotherapeutic agent. "
3.	Autoimmune Diseases (Autoimmune Disease) 07/01/1995 - "Inhibitors of purine nucleoside phosphorylase may have therapeutic value in the treatment of T-cell proliferative diseases such as T-cell leukemia, in the suppression of host-versus-graft response in organ transplants, and in the treatment of T-cell-mediated autoimmune diseases. " 07/01/2010 - "Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies." 03/01/2010 - "Purine nucleoside phosphorylase (PNP) deficiency is a rare combined immunodeficiency disorder presenting with clinically recurrent infections, failure to thrive, various neurological disorders, malignancies, and autoimmune diseases. "
4.	Hematologic Neoplasms (Hematological Malignancy) 05/01/1982 - "[Adenosine deaminase and purine nucleoside phosphorylase activities of various cultured cell lines derived from human hematologic malignancies]." 07/01/2010 - "Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies."
5.	Purine Nucleoside Phosphorylase Deficiency 11/01/2023 - "Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive combined immunodeficiency. " 01/01/2022 - "In this issue of the JCI, Abt and colleagues report on purine nucleoside phosphorylase (PNP) deficiency, exploring the basis for the autoimmune complications that develop in this particular form of T cell immune deficiency and assigning a key role for overactivation of TLR7." 09/29/2021 - "Early Diagnosis and Treatment of Purine Nucleoside Phosphorylase (PNP) Deficiency through TREC-Based Newborn Screening." 04/01/2016 - "Purine nucleoside phosphorylase (PNP) deficiency has been recently introduced in the newborn screening program in Tuscany. " 01/01/2016 - "21-year-old G1P0 with purine nucleoside phosphorylase (PNP) deficiency delivered a viable infant vaginally at 37 weeks. "

Related Drugs and Biologics

1.	forodesine
2.	Nucleosides
3.	1,2-epoxy-3-(p-nitrophenoxy)propane
4.	fludarabine phosphate (Fludara)
5.	Adenine
6.	6-methylpurine
7.	Cladribine
8.	2-bromo-2'-deoxyadenosine
9.	Adenosine Deaminase
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Organ Transplantation
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Platelet Transfusion (Blood Platelet Transfusions)
5.	Drug Therapy (Chemotherapy)