|1.||Asthma (Bronchial Asthma)
|2.||Idiopathic Pulmonary Fibrosis
|3.||Sarcoidosis (Schaumann Disease)
|4.||Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis)
|1.||Miyazaki, Eishi: 11 articles (04/2013 - 04/2002)|
|2.||Kumamoto, Toshihide: 10 articles (04/2013 - 04/2002)|
|3.||Ando, Masaru: 9 articles (04/2013 - 04/2002)|
|4.||Varga, Steven M: 8 articles (03/2009 - 04/2002)|
|5.||Matsuno, Osamu: 7 articles (01/2010 - 01/2007)|
|6.||Nureki, Shin-ichi: 6 articles (04/2013 - 04/2002)|
|7.||Toews, Galen B: 6 articles (04/2012 - 06/2002)|
|8.||Huffnagle, Gary B: 6 articles (04/2012 - 06/2002)|
|9.||Ueno, Takuya: 6 articles (10/2010 - 01/2007)|
|10.||Olson, Matthew R: 5 articles (03/2009 - 01/2007)|
|1.||Diethylcarbamazine (Hetrazan)FDA Link
02/01/1994 - "Six of them, on the other hand, responded to diethyl carbamazine (DEC) alone and 17 others, following deworming, required further DEC therapy for successful eosinopenic remission, thus warranting a diagnosis of Tropical Pulmonary Eosinophilia (TPE)."
03/01/2010 - "The mechanism of action of diethylcarbamazine (DEC), an antifilarial drug effective against tropical pulmonary eosinophilia, remains controversial. "
11/01/1994 - "The other 6 non responsive patients like the 13 who did not have parasitic infestation, needed treatment with diethylcarbamazine for eosinopenic remission and thus could be classified as patients of tropical pulmonary eosinophilia (TPE). "
12/01/1993 - "Eosinopenic remission was documented in 135 of 182 cooperative patients who were considered to have tropical pulmonary eosinophilia and agreed to be treated with diethylcarbamazine. "
06/01/2012 - "Actually he was suffering from tropical pulmonary eosinophilia and showed response to combined diethylcarbamazine and corticosteroid therapy. "
|2.||Interleukin-5 (Interleukin 5)IBA
12/01/2001 - "A study was undertaken to determine whether inhaled and intravenous IL-5 could induce pulmonary eosinophilia and bronchial hyperresponsiveness (BHR) independently of these effects. "
09/01/1998 - "Our studies examined the role of interleukin-5 (IL-5) in helminth-induced pulmonary eosinophilia and AHR. "
07/01/1992 - "These studies demonstrate the importance of IL-5 to pulmonary eosinophilia in challenged, allergic guinea pigs."
03/01/2013 - "IL-33 is considered to be a local key molecule for triggering pulmonary eosinophilia, together with IL-5. "
02/01/2004 - "Pulmonary eosinophilia and excess IL-5 were further enhanced in Der f- and cysLT-pulsed DC-harboring mice. "
|3.||Immunoglobulin E (IgE)IBA
12/01/1995 - "The present study tested the hypothesis that this pulmonary eosinophilia could be IgE-mediated. "
01/01/2008 - "AIP1 significantly reduced pulmonary eosinophilia and Th2 cytokine expression in the lungs as well as serum IgE levels. "
01/01/2007 - "Interestingly, in the NKT cell-lacking TSLP transgenic mice, pulmonary eosinophilia and increase in IgE did not improve. "
06/01/2006 - "Patients with acute or chronic eosinophilic pneumonia had significantly increased total serum IgE levels compared with healthy controls regardless as atopic status (p<0.001). "
02/01/2004 - "Specific IgE and pulmonary eosinophilia were also measured. "
08/01/2008 - "The aim of this study was to assess clinical signs and altered pulmonary cell expression of cytokines related to eosinophil kinetics in horses with pulmonary eosinophilia. "
06/01/1996 - "The purpose of this study was to determine which cytokines are associated with acute eosinophilic pneumonia. "
03/01/2013 - "We investigated the levels of IL-33 in eosinophilic pneumonia (EP) together with associated cytokines, and discussed the clinical significance of IL-33 in EP. "
01/01/2012 - "We found that LAC1 gene deletion decreased the pulmonary fungal burden and abolished CNS dissemination at weeks 2 and 3. Furthermore, LAC1 deletion lead to: 1) diminished pulmonary eosinophilia; 2) increased accumulation of CD4+ and CD8+ T cells; 3) increased Th1 and Th17 cytokines yet decreased Th2 cytokines; and 4) lung macrophage shifting of the lung macrophage phenotype from M2- towards M1-type activation. "
03/01/2009 - "The results show that the FVB/NJ and BALB/cJ mice are higher Th2-responders than the C57BL/6J mice and that the levels of pulmonary eosinophilia and cytokines did not fully track with MCH responsiveness. "
09/01/1995 - "Because appropriate treatment for those different pulmonary eosinophilia conditions requires different drugs and management, and because delay in effective treatment results in significant morbidity in such patients, diagnostic capabilities must be improved by identifying and obtaining unique antigens that can serologically discriminate between filarial TPE and other similar, but non-filarial, pulmonary eosinophilia syndromes."
01/01/2014 - "Although chronic eosinophilic pneumonia is an idiopathic disorder of unknown etiology, our case suggests that inhaled environmental antigens in the home may be associated with the causes of chronic eosinophilic pneumonia. "
01/01/2014 - "Since eosinophilic pneumonia was diagnosed simultaneously in the patient and her tame cat, it can be suggested that inhaled environmental antigens in the home caused the eosinophilic pneumonia. "
01/01/2014 - "Chronic eosinophilic pneumonia occurs predominantly in middle-aged women and non-cigarette smokers, which leads to the speculation that environmental antigens, particularly in the home, contribute to the etiology. "
01/01/2012 - "The BALF of this mouse model of eosinophilic pneumonia induced by the Ascaris suum antigen contained increased numbers of inflammatory cells and elevated Gal-9 levels. "
01/15/2011 - "Anti-CCR3 treatment markedly reduced pulmonary eosinophilia (> 80%) over the course of HDM exposure but had no effect on the remaining inflammatory response, the extent of lung Th2 cells, or the development of remodeling-associated changes, including subepithelial collagen deposition and smooth muscle thickening. "
03/01/2013 - "The types of ILD were idiopathic pulmonary fibrosis (n = 96), collagen vascular disease (n = 10), silicosis (n = 9), drug induced (n = 3), and eosinophilic pneumonia (n = 2). "
08/01/1978 - "Electron microscopic studies of lung were made and compared in 17 patients with lung disease (10 with idiopathic pulmonary fibrosis, 3 with collagen--vascular diseases, 3 with sarcoidosis, and 1 with chronic eosinophilic pneumonia) and in 5 control patients. "
01/01/1982 - "Ultrastructural studies were made of the types of alveolar epithelial cells in fibrotic lungs from 34 patients, including 20 with idiopathic pulmonary fibrosis, five with collagen-vascular diseases, six with sarcoidosis, one with lymphangioleiomyomatosis, one with histiocytosis X, and one with chronic eosinophilic pneumonia. "
03/01/1992 - "A light and electron microscopy study was performed on endothelial cells of alveolar capillaries in biopsied lung tissues obtained from 28 patients with interstitial fibrotic lung diseases, including idiopathic pulmonary fibrosis, sarcoidosis, hypersensitivity pneumonitis, chronic eosinophilic pneumonia, collagen vascular diseases and acute interstitial pneumonia. "
|7.||Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
08/01/2005 - "The aim of this study was to determine the clinical roles of the levels of KL-6, SP-A, and SP-D in the serum and bronchoalveolar lavage fluid (BALF) of patients with acute eosinophilic pneumonia (AEP). "
07/01/2004 - "[A case of acute eosinophilic pneumonia with a disassociation between the KL-6 level and SP-A and SP-D levels in the serum and BAL fluid]."
02/01/2001 - "Treatment with SP-A, SP-D, and rSP-D lowered blood eosinophilia, pulmonary infiltration, and specific Ab levels considerably, which persisted up to 4 days in the SP-A-treated ABPA mice, and up to 16 days in the SP-D- or rSP-D-treated ABPA mice. "
05/01/2005 - "In mice mimicking human allergic bronchopulmonary aspergillosis, SP-A and SP-D suppressed IgE levels, eosinophilia, pulmonary cellular infiltration and cause a marked shift from a pathogenic Th2 to a protective Th1 cytokine profile. "
06/01/2005 - "Intranasal treatment with SP-D or rhSP-D (a recombinant fragment of human SP-D containing trimeric C-type lectin domains) was effective in rescuing the Afu-sensitized DKO mice, while SP-A-treated Afu-sensitized AKO mice showed several-fold elevated levels of IL-13 and IL-5, resulting in increased pulmonary eosinophilia and damaged lung tissue. "
09/01/2015 - "Taken together, these results demonstrate that natural helper cells may play an important role in RSV-induced pulmonary eosinophilia by producing IL-13 via the IL-33/ST2 pathway. "
09/01/2015 - "Natural helper cells contribute to pulmonary eosinophilia by producing IL-13 via IL-33/ST2 pathway in a murine model of respiratory syncytial virus infection."
08/01/2005 - "Allergic asthma is a complex disorder characterized by local and systemic T helper type 2 -cell responses such as the production of IL-13, a cytokine associated with the induction of airway hyper-responsiveness (AHR), chronic pulmonary eosinophilia, airway mucus overproduction and eosinophilic oesophagitis. "
01/15/1999 - "Moreover, while granuloma formation was partially reduced in IL-4-deficient mice, blocking IL-13 in these animals almost completely abrogated granuloma development and the pulmonary eosinophilia, while it simultaneously increased IFN-gamma production. "
05/01/2013 - "Transgenic mice over-expressing IL-13 in the lung develop several characteristics of asthma such as pulmonary eosinophilia, airway epithelial hyperplasia, mucus cell metaplasia, sub-epithelial fibrosis, charcot-Leyden-Like crystals, airways obstruction, and non-specific airways hyper-responsiveness to cholinergic stimulation. "
|9.||Adrenal Cortex Hormones (Corticosteroids)IBA
10/01/2004 - "The clinical course and the treatment with corticosteroids improved chest radiographic findings quickly confirmed the diagnosis of chronic eosinophilic pneumonia. "
06/01/2015 - "Clinical outcomes in patients with acute eosinophilic pneumonia not treated with corticosteroids."
07/01/2013 - "This is the first report of idiopathic acute eosinophilic pneumonia developing in a current user of systemic corticosteroids. "
01/01/2009 - "In keeping with the suspicion of acute eosinophilic pneumonia, the patient responded dramatically to corticosteroids before antifungal therapy was initiated. "
07/01/2003 - "Chronic eosinophilic pneumonia: treatment with inhaled corticosteroids."
|10.||Complement System Proteins (Complement)IBA
06/01/1992 - "Complement evaluation was performed in two patients with active eosinophilic pneumonia and in one in remission, to determine the role of complement activation in the pathogenesis of this disorder. "
04/01/2010 - "Results of earlier studies to evaluate the possible role of complement system in tropical pulmonary eosinophilia (TPE) using classical methods like serum haemolyte component CH50, C3 and C4 levels were inconclusive. "
06/01/1992 - "Evaluation of complement in patients with eosinophilic pneumonia."
05/01/1982 - "Following antigen-antibody reaction a non-complement-mediated eosinophilic pneumonia with numerous macrophages developed. "
05/01/1978 - "Serum immunoglobulin and complement levels in tropical pulmonary eosinophilia, and their correlation with primary and their relapsing stages of the illness."
10/01/2004 - "Indeed, intranasal administration of eotaxin reconstituted pulmonary eosinophilia but not AHR and mucus hypersecretion in OVA-inhalated STAT6-/- mice. "
01/17/2003 - "Suppression of allergen reactive Th2 mediated responses and pulmonary eosinophilia by intranasal administration of an immunodominant peptide is linked to IL-10 production."
01/29/2009 - "Enhancement of ovalbumin-induced pulmonary eosinophilia by intranasal administration of alpha1-proteinase inhibitor type 2 antisense oligonucleotides."
05/01/2003 - "In the present study, we have examined the protection offered by various doses of intranasal administration of a recombinant fragment of human SP-D (rhSP-D) in a murine model of pulmonary hypersensitivity to Derp allergens which showed characteristic high levels of specific IgE antibodies, peripheral blood eosinophilia, pulmonary infiltrates and a Th2 cytokine response. "
|3.||Artificial Respiration (Mechanical Ventilation)
01/01/2008 - "We present a case of 20-year-old man, who developed idiopathic acute eosinophilic pneumonia after smoking cigarettes and required intubation with mechanical ventilation. "
10/01/2006 - "It is rare for drug-induced eosinophilic pneumonia to become so severe that mechanical ventilation is necessary. "
01/01/2014 - "Acute eosinophilic pneumonia (AEP) is a rare febrile illness which is characterized by respiratory failure and often requires mechanical ventilation. "
01/01/1990 - "Acute eosinophilic pneumonia is not a previously recognized cause of postoperative respiratory failure and prolonged mechanical ventilation. "
10/01/2006 - "We report a case of severe eosinophilic pneumonia induced by several antibiotics, requiring mechanical ventilation. "
|4.||Bone Marrow Transplantation (Transplantation, Bone Marrow)
11/19/1994 - "[Chronic eosinophilic pneumonia in a patient treated with allogeneic bone marrow transplantation]."
04/02/1994 - "[Chronic eosinophilic pneumonia in a patient treated with allogenic bone marrow transplantation]."
01/01/2011 - "[A case of eosinophilic pneumonia which occurred after bone marrow transplantation for acute myeloid leukemia]."
04/02/1994 - "A 39 year old patient diagnosed of severe aplastic anemia and treated with allogenic bone marrow transplantation and who presented chronic eosinophilic pneumonia eight months after the transplant is presented. "
12/01/1992 - "[A case of eosinophilic pneumonia with diffuse reticular shadows and scattered nodular shadows on chest X-ray film--comparison of findings of chest X-ray and lung histology]."
07/01/1992 - "The results suggested that various types of previously reported eosinophilic pneumonia classified by sex, the presence or absence of peripheral blood eosinophilia, the degree of clinical symptoms or peripheral blood eosinophilia, and the degree of abnormalities on chest X-ray films should be extensively reevaluated."
10/01/1989 - "[A case of eosinophilic pneumonia with acute progressive dyspnea and diffuse small nodular shadows on chest X-ray film]."