|1.||Venous Thrombosis (Deep-Vein Thrombosis)
|1.||Kline, Jeffrey A: 39 articles (10/2015 - 02/2002)|
|2.||Stein, Paul D: 34 articles (11/2014 - 12/2003)|
|3.||Goldhaber, Samuel Z: 33 articles (10/2015 - 03/2002)|
|4.||Huisman, Menno V: 30 articles (12/2015 - 02/2002)|
|5.||Wang, Chen: 29 articles (07/2015 - 08/2003)|
|6.||Büller, Harry R: 29 articles (01/2015 - 02/2002)|
|7.||Righini, Marc: 28 articles (12/2015 - 12/2004)|
|8.||Büller, H R: 28 articles (06/2015 - 06/2000)|
|9.||Pruszczyk, Piotr: 28 articles (05/2015 - 06/2003)|
|10.||Meyer, Guy: 27 articles (12/2015 - 04/2005)|
|1.||Heparin (Liquaemin)FDA LinkGeneric
09/01/1990 - "Low-dose subcutaneous heparin 5,000 IU commencing 2 hours preoperatively and continuing 12 hourly until the patient is fully mobile is unequivocally effective in preventing DVT in medical and surgical patients and, most importantly, significantly reduces the incidence of fatal postoperative pulmonary embolism and total mortality. "
06/01/1995 - "Whether thrombolysis is superior to heparin in subacute intermediate pulmonary embolism has not been proven unequivocally in terms of mortality or clinically important endpoints. "
03/01/1983 - "The efficacy of low dosage heparin in the prevention of pulmonary embolism has been assessed in a group of 177 "high risk" patients undergoing hip replacement operations compared with a control group of 236 "high risk" patients not so treated. "
01/01/1967 - "[Two cases of massive pulmonary embolism treated successfully with heparin + CY 58]."
01/01/2002 - "There is insufficient evidence to confirm either protection against pulmonary embolism or an overall benefit, or to distinguish between various applications of heparin. "
|2.||Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
09/01/2005 - "Low-molecular-weight heparin (LMWH) appears to be safe and effective for treating pulmonary embolism (PE), but its cost-effectiveness has not been assessed. "
01/01/2009 - "The authors conducted a prospective study of the efficacy of prophylactic use of low-molecular-weight heparin to prevent pulmonary thromboembolism. "
10/01/2004 - "Pulmonary embolism in medical patients: improved diagnosis and the role of low-molecular-weight heparin in prevention and treatment."
04/01/1996 - "Transesophageal echocardiography and contrast-enhanced spiral CT of the chest helped to avoid a pulmonary angiography in an elderly patient with saddle pulmonary thromboembolism and allowed for direct evaluation of its resolution during treatment with subcutaneous low molecular weight heparin."
01/01/2013 - "Patients who were diagnosed as acute pulmonary embolism (PE) and received either SC LMWH treatment or SC LMWH with thrombolytics in our hospital (a tertiary hospital) between 2000 and 2010 were included in the study. "
|3.||fibrin fragment D (D-dimer)IBA
06/15/2004 - "A clinical prediction rule for pulmonary embolism is most helpful when it is used with subsequent evaluations such as ventilation-perfusion scanning, D-dimer testing, or computed tomography. "
05/01/2009 - "The purpose of our study was to investigate whether D-dimer screening is being used effectively to determine the need for MDCT in diagnosing acute pulmonary embolism (PE) in emergency department patients. "
05/01/2011 - "Recently, a diagnostic strategy using a clinical decision rule, D-dimer testing and spiral computed tomography (CT) was found to be effective in the evaluation of patients with clinically suspected pulmonary embolism (PE). "
01/11/2006 - "A diagnostic management strategy using a simple clinical decision rule, D-dimer testing, and CT is effective in the evaluation and management of patients with clinically suspected pulmonary embolism. "
06/01/2013 - "There is therefore an urgent need for the evaluation of diagnostic strategies that safely exclude the diagnosis of acute pulmonary embolism in pregnant women without the need for diagnostic imaging, which is currently the gold standard, as no studies have confidently demonstrated the safety of ruling out VTE by clinical probability assessment combined with the use of D-dimer levels. "
|4.||Warfarin (Coumadin)FDA LinkGeneric
08/01/1987 - "Early warfarin therapy in the treatment of acute pulmonary embolism appears to be both cost-effective and safe. "
12/01/2013 - "[A randomized controlled study of the VKORC1 and CYP2C9 genotypes in guiding warfarin therapy for pulmonary thromboembolism]."
01/01/2011 - "Further familial study was performed, and the patient's older sister was revealed to have the same mutation; she was already taking warfarin due to diagnosed pulmonary thromboembolism. "
08/01/1999 - "Clinical trials are currently investigating the potential value of LMWHs in the treatment of pulmonary embolism and as an alternative to warfarin in secondary prevention of DVT. "
08/01/2015 - "Extended warfarin treatment after pulmonary embolism."
|5.||Enoxaparin (Lovenox)FDA LinkGeneric
08/01/2007 - "After three weeks of enoxaparin therapy, her symptoms and pulmonary embolism on CT improved. "
06/01/2003 - "Following our study we can conclude that extended 3-month treatment with enoxaparin as monotherapy for symptomatic, acute pulmonary embolism is feasible and warrants further study in a large clinical trial."
01/01/1994 - "No clinically symptomatic pulmonary embolism was observed during the treatment or follow-up phase of this study in the group that received thirty milligrams of enoxaparin every twelve hours. "
11/01/2015 - "Prescription of enoxaparin is associated with decreasing pulmonary embolism mortality rate in Germany."
09/01/2015 - "Three patients in the IPC-alone group developed pulmonary embolism, but none in the enoxaparin group did so (Fisher's exact test, P = 0.10). "
02/01/2015 - "Anticoagulants are the mainstay of treatment for acute pulmonary embolism; however, in patients with massive or submassive pulmonary embolism, advanced therapy with thrombolytics may be considered. "
10/01/2012 - "Although improved surgical techniques and widespread use of anticoagulants have substantially reduced the incidence of thromboembolic events, venous thromboembolic disease is still a dangerous complication and, in these patients, pulmonary embolism remains the main cause of death. "
01/01/1993 - "Although oral anticoagulants appear to be particularly effective for the prevention of fatal pulmonary embolism, it is not clear that their efficacy is directly related to the prothrombin time."
11/01/2001 - "This study reports the efficacy of adjusted low-dose oral anticoagulants in the prevention of fatal pulmonary embolism after hip fracture. "
11/01/1988 - "This prospective study was designed to obtain information on the fate of patients with severe pulmonary embolism who received anticoagulants as first-line treatment, in order to identify those in whom other treatments available might be expected to reduce mortality or sequelae. "
|7.||4- ((1,4,8,11- tetraazacyclotetradec- 1- yl)methyl)benzoic acidIBA
10/01/2014 - "Eighty kilovoltage CTPA with HIR provides improved image quality and conspicuity of pulmonary embolism enabling low dose CTPA protocols close to 1 mSv in patients weighing less than 80 kg."
04/01/2014 - "CT pulmonary angiography (CTPA) is considered the gold standard for the diagnosis of pulmonary embolism (PE) and is frequently performed in patients with cardiopulmonary complaints. "
01/01/2014 - "Computed tomographic pulmonary angiography (CTPA) is a gold standard test for the diagnosis of pulmonary embolism (PE), but is reported to be over prescribed. "
12/01/2012 - "Computed tomography pulmonary angiography (CTPA) is considered as clinical gold standard for diagnosing pulmonary embolism (PE). "
08/01/2012 - "To identify reasons for ordering computed tomography pulmonary angiography (CTPA), to identify the frequency of reasons for CTPA reflecting defensive behavior and evidence-based behavior, and to identify the impact of defensive medicine and of training about diagnosing pulmonary embolism (PE) on positive results of CTPA. "
|8.||Tissue Plasminogen Activator (Alteplase)FDA Link
01/01/2008 - "Authors consider alteplase to be highly effective in the treatment of massive pulmonary embolism. "
12/01/1989 - "A case of pulmonary thromboembolism in a young woman three days status post-abdominal surgery is treated successfully with a low-dose infusion rate of tissue plasminogen activator (10 mg/hr over 10 h). "
01/01/2008 - "[The efficacy of alteplase in pulmonary embolism treatment]."
02/01/1988 - "To determine if pulmonary perfusion was improved in acute pulmonary embolism after therapy with recombinant human tissue-type plasminogen activator (rt-PA), lung scans were obtained before and a mean of 22 hours after therapy in 19 patients. "
12/01/2015 - "The aim of this study was to evaluate the association between admission CK-MB levels and in-hospital and long-term clinical outcomes in pulmonary embolism (PE) patients treated with thrombolytic tissue-plasminogen activator. "
07/01/2010 - "[Massive pulmonary thromboembolism treated successfully with streptokinase. "
08/01/1976 - "As a result of the case described the administration of streptokinase in a high initial dosage of about 750,000-1,000,000 U within a few minutes appears to be effective in serious lethal pulmonary embolism. "
01/01/1983 - "The efficacy of streptokinase was studied in an open trial on 30 consecutive patients with major pulmonary embolism, affecting at least three lobar arteries in pulmonary angiography. "
01/01/1983 - "It is concluded that streptokinase treatment of major pulmonary embolism is effective and safe in rapidly restoring pulmonary perfusion."
12/01/2001 - "High dose and short-term streptokinase infusion in patients with pulmonary embolism: prospective with seven-year follow-up trial."
|10.||Adenosine Diphosphate (ADP)IBA
08/01/2014 - "siceraria showed a significant increase in tail bleeding time and plasma recalcification time, significant protection against ADP induced pulmonary thromboembolism in mice, and also inhibited the platelet aggregation induced by ADP in vitro. "
06/01/2002 - "PMC was also effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism in mice when administered intravenously at doses of 5 and 10 microg/g. "
10/01/2010 - "The effect to venous thrombosis model and pulmonary thromboembolism model induced by vein injecting ADP and Adr was observed. "
07/01/2012 - "Grade 3/4 toxic effects for ADP versus placebo-DP were cardiac events (5% versus 2%), lymphopenia (23% versus 16%), neutropenia (47% versus 40%), ileus (2% versus 0%) and pulmonary embolism (6% versus 2%). "
12/01/2011 - "In vivo studies revealed that andrographolide (22 and 55 μg/kg) is effective in reducing the mortality of ADP-induced acute pulmonary thromboembolism and significantly prolonged platelet plug formation in mice. "
06/18/2014 - "Thrombolytic therapy may be beneficial in the treatment of some patients with pulmonary embolism. "
12/01/2009 - "Acute massive pulmonary embolism with hemodynamic compromise treated successfully with thrombolytic therapy."
09/01/1998 - "This case suggests that delayed thrombolytic therapy in patients with massive pulmonary embolism can still be beneficial in selected cases, even if given more than 2 weeks after symptom onset."
06/01/1996 - "We found a significant ABD-assisted right ventricular hypokinetic regression after thrombolytic therapy in acute pulmonary embolism but could not demonstrate a linear relation between improvement in early right ventricular function and angiography."
06/01/1989 - "Many investigators have reported about beneficial results with thrombolytic therapy in patients with acute pulmonary embolism. "
|2.||Vena Cava Filters (Inferior Vena Cava Filter)
08/01/2014 - "It has been proven that the use of an inferior vena cava filter (IVCF) is effective in decreasing the incidence of pulmonary embolism (PE) in high-risk spinal surgery patients. "
09/15/2010 - "To evaluate the safety and efficacy of prophylactic inferior vena cava filter (IVCF) to prevent pulmonary embolism (PE) in high risk patients undergoing major complex spinal surgery. "
01/01/2009 - "Retrievable inferior vena cava filters (IVCFs) offer protection against pulmonary embolism during this high-risk period, when anticoagulation is discontinued, while avoiding potential long-term sequelae of a permanent IVCF. "
05/01/2008 - "A retrievable inferior vena cava filter, as an adjunct to chemical and mechanical prophylaxis, was a safe and effective means of reducing the acute risk of pulmonary embolism in this high-risk group of patients. "
11/01/2005 - "The OptEase permanent/retrievable vena cava filter can be safely and successfully retrieved up to 14 days in patients who no longer require inferior vena cava filter protection against pulmonary embolism."
06/01/2014 - "Successful management of acute massive pulmonary embolism using Angiovac suction catheter technique in a hemodynamically unstable patient."
09/01/2004 - "Mean treatment time was 124.6 min. Hybrid treatment with mechanical fragmentation using a rotating pigtail catheter combined with local fibrinolysis and manual clot aspiration resulted in a rapid and safe improvement in the hemodynamic condition of patients with acute massive pulmonary thromboembolism. "
10/01/2014 - "Catheter-directed thrombolytic intervention is effective for patients with massive and submassive pulmonary embolism."
10/01/2014 - "Catheter-directed thrombolytic (CDT) therapies for severe pulmonary embolism (PE) have been shown to be effective and safe when compared with systemic thrombolysis in adults. "
10/01/2008 - "Subsequently and in the acuteness, a catheter interventional PFO-closure via a double-umbrella device was placed and the pulmonary embolism was effectively treated by a local lysis through the insertion of a pigtail-catheter into the right pulmonary artery."
04/01/2007 - "Open pulmonary embolectomy is the most effective treatment for acute massive pulmonary embolism. "
11/01/2001 - "Emergency surgical pulmonary embolectomy is a highly effective treatment for selected patients with pulmonary embolism. "
07/01/1991 - "Transesophageal echocardiography seems to be a very helpful technique to diagnose promptly massive pulmonary embolism and a very useful tool at the time of operation to guide the embolectomy."
02/01/1977 - "We present the findings in a patient with acute massive pulmonary embolism who underwent transvenous pulmonary embolectomy, with immediate and marked improvement in hemodynamic function and survival. "
01/01/2007 - "[Massive pulmonary embolism treated successfully with embolectomy following failed thrombolysis--the role of repeated spiral computerised tomography and echocardiography--a case report]."
07/01/2007 - "Percutaneous rheolytic thrombectomy for large pulmonary embolism: a promising treatment option."
01/01/2007 - "We illustrate here that percutaneous mechanical thrombectomy can be a safe and effective method of treating massive pulmonary embolism when thrombolysis is relatively contraindicated. "
08/01/1997 - "In conclusion, antithrombotic PCPS is very useful to care massive pulmonary embolism with thrombectomy."
09/01/1990 - "The fibrinolytic treatment for right atrial thromboemboli during multiple pulmonary embolism is a promising alternative to right atrial thrombectomy: our results indicate that rt-PA acts rapidly and is effective and safe; if these results will be confirmed in a larger group of patients, rt-PA could become the first-choice therapy of right atrial thromboembolus."
10/21/1997 - "A new treatment for severe pulmonary embolism: percutaneous rheolytic thrombectomy."