Psychomotor Agitation (Akathisia)

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1191 relevant articles (108 outcomes, 110 trials/studies) found for this Disease

Description: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.

Also Known As:

Akathisia; Restlessness; Psychomotor Hyperactivity; Psychomotor Restlessness; Hyperactivity, Psychomotor; Psychomotor Excitement; Restlessness, Psychomotor; Agitation, Psychomotor; Excitement, Psychomotor

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinsonian Disorders (Parkinsonism)
2.	Tremor (Tremors)
3.	Schizophrenia (Dementia Praecox)
4.	Dyskinesias (Dyskinesia)
5.	Syndrome

Experts

1.	Weizman, Abraham: 5 articles (06/2006 - 05/2003)
2.	Poyurovsky, Michael: 4 articles (06/2006 - 05/2003)
3.	Lima, A R: 3 articles (01/2004 - 01/2002)
4.	Bacaltchuk, J: 3 articles (01/2004 - 01/2002)
5.	Weizman, A: 3 articles (12/2001 - 05/2001)
6.	Vinson, David R: 2 articles (08/2006 - 04/2004)
7.	Fuchs, Camil: 2 articles (06/2006 - 06/2003)
8.	Weizman, Ronit: 2 articles (06/2006 - 06/2003)
9.	Statsenko, Nikolay: 2 articles (03/2006 - 11/2004)
10.	Miodownik, Chanoch: 2 articles (03/2006 - 11/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Psychomotor Agitation:

1.	Propranolol (Inderal)FDA LinkGeneric 01/01/2000 - "Based on the available literature, propranolol or other lipophilic beta-blockers seem to be the most consistently effective treatment for acute akathisia" 08/01/1993 - "Propranolol failed to produce a significant improvement overall in any of the akathisia measures, with only one patient showing clinical improvement" 02/01/1991 - "Eight patients were subsequently treated in a nonblind manner with racemic propranolol, with a significant reduction in akathisia scores" 01/01/1988 - "Neither propranolol nor placebo treated patients showed a significant improvement in akathisia" 01/01/1989 - "This study shows that 120 mg of propranolol a day is more effective than placebo in reducing akathisia, and that propranolol's antiakathisic effect may require several days of treatment." Order ALL the reference details at left...
2.	Antipsychotic Agents (Antipsychotics)IBA 10/01/2008 - "Based on preliminary studies with antipsychotic drugs, a subgroup of patients who experience akathisia may be particularly vulnerable to suicide" 09/01/2008 - "CONCLUSION: Second-generation antipsychotics seem to reduce psychomotor agitation and aggressive behavior in patients with autistic spectrum disorder; however, further studies are required to evaluate the side effects of these drugs in relation to their beneficial effects." 01/01/2007 - "The aim of this study was to find out if the use of conventional antipsychotics is associated with an increased risk of akathisia (compared with atypical antipsychotics) even when low doses of conventional antipsychotics are used" 11/01/2002 - "The purpose of this study was to characterize the subjectively experienced symptoms and cognitive impairment associated with akathisia, which is among the most disabling adverse effects associated with antipsychotic drugs" 01/01/1995 - "The studies suggest that a significant proportion of patients chronically treated with neuroleptics suffer from akathisia" Order ALL the reference details at left...
3.	olanzapine (Zyprexa)FDA Link 12/01/2006 - "In our case study we describe the appearance of akathisia next to olanzapine therapy in the case of a 65 years old woman, and an overview of the literature have reference to adverse events of olanzapine." 12/01/2006 - "Akathisia in the course of olanzapine treatment]" 12/01/2006 - "METHODS: Using [18]-FDG-PET, imaging patterns of cortical metabolic activity were obtained in a patient during olanzapine-induced akathisia and after recovery" 12/01/2006 - "Cerebellar and thalamic metabolic changes visualized by [18]-FDG-PET in olanzapine-induced acute akathisia." 06/01/2006 - "Higher-dose olanzapine exhibited a tolerance profile similar to that of 20 mg/d; however, akathisia may be more likely to occur at higher doses, particularly in subjects with a history of akathisia." Order ALL the reference details at left...
4.	Haloperidol (Haldol)FDA LinkGeneric 06/01/2001 - "Haloperidol was associated with a non-significant reduction in LI scores, and dysphoria/akathisia (Barnes Akathisia Rating Scale) in three-quarters of the subjects" 04/01/1993 - "Our study, therefore, replicates the findings of Sanberg (1980) and Russell et al. (1987a, 1987b) that haloperidol increases "emotional" defecation in rats in well-habituated environments, but the same model does not replicate the motor component of neuroleptic-induced akathisia seen in human subjects." 05/01/1983 - "Biochemical and psychophysiological study of haloperidol-induced akathisia]" 05/01/2006 - "The most common side effects caused by haloperidol were sedation and akathisia, the latter being more troublesome" 07/01/2004 - "One patient in the haloperidol group experienced mild akathisia, but no other patients reported clinically significant side effects" Order ALL the reference details at left...
5.	MianserinIBA 09/01/1997 - "Seven mianserin-treated patients improved and five revealed complete disappearance of neuroleptic-induced akathisia" 09/01/1997 - "It contrast, it appears that low-dose mianserin is therapeutically effective in acute neuroleptic-induced akathisia." 10/04/2000 - "Improvement in a patient with severe akathisia achieved by mianserin]" 03/01/1999 - "AIM: To evaluate the efficacy of the 5-HT2 antagonist, mianserin in neuroleptic-induced akathisia" 03/01/1999 - "CONCLUSIONS: Mianserin at a low dose may be a promising therapeutic option for patients with acute neuroleptic-induced akathisia." Order ALL the reference details at left...
6.	Risperidone (Risperdal Consta)FDA Link 10/01/2004 - "RESULTS: On the CMAI, risperidone was significantly more effective in treating hitting (p = .000), hurt self or other (p = .005), cursing or verbal aggression (p = .000), repetitive sentences or questions (p = .001), scratching (p = .041), general restlessness (p = .001), grabbing onto people (p = .028), constant request for attention (p = .041), pacing and aimless wandering (p = .013), and performing repetitious mannerisms (p = .045)" 03/01/2003 - "MAIN OUTCOMES AND RESULTS: The patient demonstrated a reduction in restlessness in response to the use of risperidone, which permitted wound healing" 08/01/2002 - "One patient dropped out after 1 week due to the occurrence of akathisia associated with markedly increased plasma risperidone concentrations" 05/01/2002 - "CONCLUSIONS: Symptoms typical of RLS may be induced by risperidone treatment and should be differentiated from akathisia" 05/01/2002 - "BACKGROUND: According to some reports, patients treated with risperidone may develop akathisia" Order ALL the reference details at left...
7.	Fluoxetine (Prozac)FDA LinkGeneric 01/01/1996 - "Substantial emergence of psychomotor agitation also occurred at a similar incidence across the three treatment groups and typically appeared within the first 3 wk. Improvement in agitation was significantly more prominent (P < 0.001) among fluoxetine-treated than among placebo-treated patients" 01/01/1996 - "Data derived from this large series of clinical trials suggested no evidence that either fluoxetine or TCAs induced psychomotor agitation at rates exceeding the natural course of the disorder over time (placebo cohort)" 09/01/1994 - "Recent studies have suggested, however, that fluoxetine (Prozac) may in fact lead to suicidal behavior because the drug appears to adversely affect serotonergic neuronal discharge and induce an akathisia-like extrapyramidal reaction" 12/01/2003 - "The patient developed severe restlessness and de novo suicidal ideation approximately 1 week after the dosage of fluoxetine was doubled, 1 year on from when the drug was first introduced" 12/01/2003 - "We report the case of a 22-year-old woman presenting major depressive episode with severe akathisia after an increase in fluoxetine" Order ALL the reference details at left...
8.	Clozapine (Clozaril)FDA LinkGeneric 04/01/1994 - "While our previous experience indicates that clozapine is effective in treating persistent akathisia, two controlled studies indicate vastly different prevalence rates of akathisia (7% vs. 40%) in patients receiving clozapine" 04/01/1993 - "We believe that clozapine is a very useful drug for the relief of nocturnal akathisia in parkinsonian subjects." 07/01/1992 - "Future controlled trials of clozapine that specifically investigate persistent akathisia may answer this question more conclusively." 04/01/2007 - "Acute nocturnal akathisia induced by clozapine." 01/01/2005 - "Tardive nocturnal akathisia due to clozapine treatment." Order ALL the reference details at left...
9.	Clonazepam (Rivotril)F