|3.||Atopic Dermatitis (Atopic Eczema)
|1.||Abelson, Mark B: 25 articles (08/2011 - 03/2002)|
|2.||Kuraishi, Yasushi: 20 articles (01/2015 - 10/2002)|
|3.||Ständer, Sonja: 20 articles (07/2014 - 12/2002)|
|4.||Yosipovitch, Gil: 19 articles (05/2015 - 11/2003)|
|5.||Beuers, Ulrich: 18 articles (04/2015 - 09/2002)|
|6.||Andoh, Tsugunobu: 17 articles (11/2015 - 03/2003)|
|7.||Ständer, S: 13 articles (12/2015 - 03/2001)|
|8.||Kremer, Andreas E: 13 articles (04/2015 - 09/2010)|
|9.||Steinhoff, Martin: 13 articles (06/2014 - 12/2002)|
|10.||Weisshaar, Elke: 13 articles (09/2012 - 05/2003)|
|1.||Morphine (MS Contin)FDA LinkGeneric
03/01/2015 - "In this study, treatment with a peripherally acting μ-opioid antagonist was generally ineffective against intrathecal morphine-induced pruritus, but a small clinical effect cannot be excluded. "
03/01/2015 - "The aim of this study was to determine if a peripherally acting, μ-opioid antagonist would reduce morphine-induced pruritus. "
10/01/2002 - "Although the mediators and exact mechanisms eliciting and sustaining pruritus are not completely known, AE patients in clinical trials have been shown to benefit under treatment with morphine antagonists. "
08/01/1985 - "One of the frequently reported side effects following epidural morphine administration in clinical trials is a generalized pruritus of several hours duration. "
05/01/1984 - "Two patients in group I and one patient in group II had generalized pruritus, and in one study patient bradypnea developed in association with the epidural administration of morphine. "
|2.||Histamine Antagonists (Antihistamines)IBA
05/01/2014 - "Topical antihistamines can generate rapid relief from acute symptoms and itching. "
11/20/2007 - "Desensitization was acutely successful in all 24 patients, and by 6-month follow-up, 1 patient had persistent but improved pruritus controlled with oral antihistamines and 23 remained asymptomatic, with only 2 patients requiring repeat desensitization. "
11/01/2014 - "Drug avoidance is the mainstay of treatment, and antihistamines can reduce associated pruritus. "
10/19/2011 - "In many diseases, pruritus is not effectively treated with antihistamines, indicating the involvement of nonhistaminergic mechanisms. "
08/01/2010 - "Of seven grade B trials, four supported the efficacy of topical antihistamines while three refute their use in relieving pruritus. "
|3.||Ursodeoxycholic Acid (Urso)FDA LinkGeneric
12/01/1992 - "Ursodeoxycholic acid has been beneficial in pruritus and in liver function tests; an improvement in fetal prognosis should be evaluated in future controlled studies."
03/01/1997 - "Ursodeoxycholic acid (UDCA) administration provides a significant improvement in maternal pruritus and in the biochemical abnormalities, with no adverse effects in the mother or child. "
03/01/1992 - "During the initial 12 months urso treatment liver function tests improved significantly in all patients, pruritus improved in 60% of patients. "
01/01/2013 - " with placebo, ursodeoxycholic acid (UDCA) showed improvement in pruritus in five (228 women) out of seven trials. "
04/01/2014 - "The child was started on ursodeoxycholic acid following which the itching improved. "
|4.||Histamine (Histamine Dihydrochloride)FDA Link
07/01/2014 - "The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects."
07/01/2014 - "In conclusion, JNJ 39758979 was effective in inhibiting histamine-induced pruritus in healthy subjects. "
07/01/2014 - "A clinical study was conducted to evaluate the safety and efficacy of the H4R antagonist, JNJ 39758979 [(R)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine], on histamine-induced pruritus in healthy subjects. "
01/01/1985 - "Placebo-controlled study of the efficacy of topical antihistaminics against histamine-induced pruritus."
10/01/2000 - "The anti-histamine loratidine (orally, 1.7 microg/ g/day, for 4 weeks) reduced the severity of the lesions macroscopically, probably by suppressing the pruritus. "
|5.||Ondansetron (Zofran)FDA LinkGeneric
10/01/1998 - "Although under treatment with ondansetron a significant improvement of itching as assessed by the VAS score was demonstrated, this treatment was not preferred over placebo by the patients. "
03/01/1999 - "We have evaluated the efficacy of ondansetron in the prevention of opioid-induced pruritus in a prospective, randomized, double-blind, placebo-controlled study. "
11/01/2012 - "Ondansetron was demonstrated to have negligible effect on cholestatic or uremic pruritus on the basis of a limited number of studies."
11/01/2012 - "Overall, three studies showed no benefit to ondansetron over placebo; however, two studies in cholestatic pruritus showed small reductions in pruritus with questionable clinical significance. "
11/01/2012 - "Electronic databases were systematically searched for randomized controlled trials examining the role of ondansetron in cholestatic or uremic pruritus between 1966 and 2008. "
|6.||Tacrolimus (Prograf)FDA LinkGeneric
03/01/2014 - "He was given 0.1% tacrolimus ointment twice daily and experienced a marked improvement in his pruritus within 2 weeks. "
01/01/2005 - "Tacrolimus ointment led to significant improvement of pruritus and severe eczematous skin lesions after 20 days of treatment. "
10/01/1998 - "The median percent reduction in pruritus was significantly greater for tacrolimus-treated patients (74% to 89%) than for vehicle-treated patients (51%, P = .027). "
03/01/2005 - "The results of this study do not demonstrate that tacrolimus ointment 0.1% is more effective than vehicle in relieving uremic pruritus."
05/01/2012 - "Use of topical tacrolimus is effective in controlling pruritis of AD compared to emollient."
|7.||Naloxone (Narcan)FDA LinkGeneric
08/01/2011 - "Some of those studies indicated a significant reduction in the frequency or severity of pruritus with use of naloxone (a low-dose, continuous i.v. infusion of naloxone appeared to be the most effective treatment). "
07/01/1985 - "Intravenous naloxone significantly decreased the incidence of pruritus during labor and delivery. "
10/01/1997 - "Naloxone had been shown to be effective in relieving pruritus of dialyzed patients. "
09/01/2009 - "Naloxone is safe and efficacious in symptomatic improvement in cholestatic pruritus."
07/01/2011 - "Analgesic efficacy of intravenous naloxone for the treatment of postoperative pruritus: a meta-analysis."
|8.||Bile Acids and Salts (Bile Acids)IBA
10/01/2014 - "Pruritus resolved in nine children with significant reduction of serum bile acids (P < 0.02). "
03/01/2012 - "Thirteen patients (54%) improved significantly, with a normalization of serum bile acids (P < .001 vs postoperatively) and lessened pruritus (P < .05 vs preoperatively) at 12 months after PEBD. "
08/01/1996 - "These findings show that UDCA is more effective than SAMe in controlling pruritus and total bile acids, which are considered a prognostic parameter in ICP with respect to the fetus. "
10/01/1981 - "Serum bile acids levels fell in all patients in whom pruritus improved but not in the patient who responded less favorably."
01/01/2015 - "A prospective observational study was performed in pregnant patients who underwent blood tests for bile acids due to persistent pruritus. "
|9.||gabapentin (Neurontin)FDA LinkGeneric
07/01/2014 - "The use of gabapentin was responsible for a significant improvement in pruritus (p=0.0020). "
01/01/2005 - "Although a double-blind placebo-controlled clinical trial should be conducted to better elucidate the efficacy and toxicity of gabapentin in patients with uremic itch, our data suggest that gabapentin could be considered an effective and safe alternative treatment for uremic pruritus."
06/25/2012 - "[Brachioradial pruritus effectively treated with gabapentin]."
06/01/2008 - "Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions. "
12/01/2004 - "Our study shows that gabapentin is safe and effective for treating uraemic pruritus in haemodialysis patients. "
|10.||Cetirizine (Zyrtec)FDA LinkGeneric
10/01/1993 - "The new H1-receptor antagonist, cetirizine, is eliminated primarily unchanged by renal excretion and is thus potentially useful for relief of pruritus in patients with hepatic dysfunction, in whom many H1-receptor antagonists are contraindicated. "
01/01/2012 - "An open clinical trial on the efficacy of cetirizine hydrochloride in the management of allergic pruritus in cats."
11/01/2002 - "The skin lesions and pruritus cleared quickly after the administration of cetirizine hydrochloride."
05/01/2004 - "The pruritus was satisfactorily reduced in 4/22 (18%) dogs that completed the trial with cetirizine. "
03/01/1990 - "In a double-blind and placebo-controlled study, 11 subjects underwent a conjunctival provocation test (CPT) with a grass pollen extract to determine the effect of cetirizine on allergen-induced itching and redness of the eye. "
|1.||Phototherapy (Light Therapy)
09/01/2012 - "Four patients (30%) needed an additional phototherapy course because of recurrent pruritus and in all of them again a marked improvement of pruritus was observed. "
09/01/2011 - "Both the NB-UVB and control groups had significant and comparable improvement in the pruritus intensity VAS scores during the period of phototherapy and follow-up. "
09/01/1997 - "UVB phototherapy can produce significant relief of pruritus and improvement in the quality of life in patients positive for HIV."
09/01/2011 - "To investigate whether or not NB-UVB phototherapy is an effective treatment for uraemic pruritus. "
07/01/2005 - "Narrowband ultraviolet B phototherapy may be an effective treatment for patients with uremic pruritus. "
01/01/2012 - "Two of these reflected a faster onset of effective analgesia from time of injection with CSE and the third was of more pruritus with CSE compared to low-dose epidural (average RR 1.80; 95% CI 1.22 to 2.65; 11 trials, 959 women; random-effects, T² = 0.26, I² = 84%). "
04/01/2008 - "This study was conducted using mice to examine whether different subtypes of mu-OR would be responsible for pruritus and analgesia. "
01/01/2003 - "Of the 25 outcomes analysed from these studies CSE shows a reduced time from first injection to effective maternal analgesia WMD -5.50 minutes (95% CI -6.47 to -4.52; four trials), an increased incidence of maternal satisfaction OR 4.69 (95% CI 1.27 to 17.29; three trials), and an increased incidence of pruritus OR 2.79 (95% CI 1.87 to 4.18; nine trials). "
09/01/2013 - "After ensuring adequate analgesia this behaviour was interpreted as pruritus. "
09/01/2013 - "In contrast, ethnically distinct hospital population groups exerted a marked effect on the time-course of both analgesia and pruritus."
05/01/2010 - "Pruritus and signs of vulvar lesions were dramatically improved following HIFU treatment, without severe complications, and 90.23% of the patients were cured or had their symptoms improved 6months after treatment. "
06/01/2011 - "Shampoo 1 showed a significantly higher anti-mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question 'The use of this shampoo decreases the itching of my scalp?' after a 4-week treatment with shampoo 1 equaled 90%. "
05/01/1995 - "In 12 children, replies to a questionnaire at up to 18 months after treatment, showed that 10 had maintained improvement in itching and scratching, nine in sleep disturbance, and seven maintained improvement in itching and scratching, nine in sleep disturbance, and seven maintained improvement in mood."
01/01/2015 - "Over the two studies, there were 18 adverse events possibly or probably associated with treatment, most of which were increased pruritus after treatment. "
01/01/2008 - "Patients reported a reduction of pruritus on visual analogue scales from 4.9 +/- 2.6 to 2.7 +/- 2.4 6 days after treatment start and a further reduction to 2.0 +/- 2.3 at study end (P < 0.001 each). "
|4.||Renal Dialysis (Hemodialysis)
01/01/2005 - "The test product appeared to be effective in reducing both pruritus and xerosis in hemodialysis patients. "
01/01/2012 - "The case of a hemodialysis patient with consistent itching and a variety of cutaneous eruptions, which after performing skin biopsy were explored and cured, is described. "
01/01/2009 - "A randomized controlled clinical trial comparing the efficacy of dead sea mineral-enriched body lotion versus two types of placebo in the treatment of cutaneous dryness, itching, peeling and tightness in hemodialysis patients (EDIT)."
10/01/2015 - "This study was carried out to determine the factors affecting and incidence of itching in patients undergoing hemodialysis treatment. "
07/01/2014 - "Pruritus in hemodialysis patients: Results from the Japanese Dialysis Outcomes and Practice Patterns Study (JDOPPS)."
03/01/2012 - "To evaluate the safety and efficacy of 'out-patient' albumin dialysis using the molecular adsorbent recirculating system (MARS) in the treatment of intractable pruritus in cholestatic patients referred for liver transplantation for symptomatic relief. "
05/01/2010 - "Partial external biliary diversion is helpful in several patients as it reduces the pruritus and postpones or even avoids liver transplantation. "
01/01/1992 - "After intensive supportive care for 2 weeks, the patient's condition gradually improved and she was discharged with mildly elevated liver enzyme levels and pruritus, without need of liver transplantation. "
11/01/2001 - "Liver transplantation for intractable pruritus is contraindicated before an adequate trial of opiate antagonist therapy."
01/01/2014 - "Of the 5 patients who underwent IE after PEBD, 1 eventually required liver transplantation, 1 developed varying degree of pruritus, and 3 female patients, operated on because of aesthetic reasons, had excellent outcomes. "