Proto-Oncogene Proteins

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

Also Known As:

Proto Oncogene Proteins, Cellular; Proto-Oncogene Products, Cellular; Cellular Proto Oncogene Proteins; Cellular Proto-Oncogene Products; Proto Oncogene Products, Cellular; Proto Oncogene Proteins; Proto-Oncogene Proteins, Cellular; c onc Proteins; Cellular Proto-Oncogene Proteins; c-onc Proteins

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        Cyclin D1: 7286
        Lipocalin-2: 2783
        Proto-Oncogene Proteins c-akt: 2595
        Janus Kinase 2: 754
        Proto-Oncogene Proteins c-met: 714
        Thyroid Hormone Receptors: 648
        Type 3 Fibroblast Growth Factor Receptor: 533
        ErbB-2 Receptor: 526
        Proto-Oncogene Proteins c-sis: 491
        fms-Like Tyrosine Kinase 3: 490
        Proto-Oncogene Proteins c-kit: 471
        Stathmin: 427
        Proto-Oncogene Proteins c-ets: 420
        c-Mer Tyrosine Kinase: 419
        raf Kinases: 360
        Proto-Oncogene Proteins c-fos: 329
        Proto-Oncogene Proteins c-mdm2: 283
        Chemokine CXCL1: 182
        Macrophage Colony-Stimulating Factor Receptor: 168
        Proto-Oncogene Proteins c-bcl-2: 141
        Bcl-2-Like Protein 11: 139
        RNA-Binding Protein FUS: 130
        Proto-Oncogene Proteins p21(ras): 128
        N-Myc Proto-Oncogene Protein: 108
        Axl Receptor Tyrosine Kinase: 103
        Proto-Oncogene Proteins c-pim-1: 84
        Proto-Oncogene Proteins c-myc: 79
        macrophage stimulating protein: 77
        Kruppel-Like Factor 6: 64
        proto-oncogene protein Spi-1: 62
        RNA-Binding Protein EWS: 61
        Proto-Oncogene Proteins c-ret: 60
        Wnt-5a Protein: 58
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck): 49
        Zinc Finger Protein GLI1: 47
        Proto-Oncogene Proteins c-fyn: 38
        Proto-Oncogene Proteins c-jun: 32
        Fibroblast Growth Factor 4: 27
        Proto-Oncogene Proteins c-hck: 24
        T-Cell Acute Lymphocytic Leukemia Protein 1: 23
        Proto-Oncogene Proteins pp60(c-src): 22
        Proto-Oncogene Proteins c-rel: 18
        Bax protein (53-86): 16
        ErbB-3 Receptor: 16
        Proto-Oncogene Proteins c-myb: 16
        ErbB-4 Receptor: 14
        Wnt1 Protein: 14
        Myeloid-Lymphoid Leukemia Protein: 13
        Notch4 Receptor: 13
        Pre-B-Cell Leukemia Transcription Factor 1: 12
        Proto-Oncogene Proteins c-vav: 12
        Proto-Oncogene Proteins c-mos: 11
        B-Cell Lymphoma 3 Protein: 9
        Proto-Oncogene Proteins c-bcr: 8
        rat Sfrp4 protein: 8
        MDS1 and EVI1 Complex Locus Protein: 7
        Proto-Oncogene Proteins c-bcl-6: 7
        Proto-Oncogene Proteins c-cbl: 7
        Wnt2 Protein: 7
        Fibroblast Growth Factor 6: 6
        Proto-Oncogene Proteins c-crk: 6
        KRIT1 Protein: 5
        Proto-Oncogene Mas: 4
        Proto-Oncogene Proteins c-abl: 4
        Proto-Oncogene Proteins c-maf: 4
        zebrafish bbc3 protein: 4
        proto-oncogene protein Pbx3: 3
        RUNX1 Translocation Partner 1 Protein: 3
        human CEP43 protein: 2
        human TET1 protein: 1
        Proto-Oncogene Proteins c-fes: 1
        Proto-Oncogene Proteins c-yes: 1
        C elegans ROL-3 protein
        chicken A-MYB protein
        Danio rerio PSMD10 protein
        dog neutrophil gelatinase-associated lipocalin protein
        Drosophila BHD protein
        Drosophila CCM3 protein
        Drosophila Ets97D protein
        Drosophila fuss protein
        Drosophila pnt protein
        Drosophila Src64B protein
        Drosophila tj protein
        Drosophila Wnt5 protein
        Gallus gallus Ju93 protein
        Gallus gallus SKIL protein
        human ACP1 protein
        human AKAP13 protein
        human BBC3 protein
        human BCOR protein
        human BNIP3 protein
        human BNIP3L protein
        human CCN4 protein
        human COPS3 protein
        human DDX6 protein
        human DNPH1 protein
        human ECT2 protein
        human FLCN protein
        human FRAT1 protein
        human GFI1B protein

Experts

1.	Asgari, Mojgan: 1 article (03/2016)
2.	Ebadi, Nader: 1 article (03/2016)
3.	Ghadakzadeh, Sara: 1 article (03/2016)
4.	Hosseini, Seyed Ali: 1 article (03/2016)
5.	Jahed, Marzieh: 1 article (03/2016)
6.	Majidizadeh, Tayebeh: 1 article (03/2016)
7.	Mivehchi, Mohamad: 1 article (03/2016)
8.	Shahshanipour, Majid: 1 article (03/2016)
9.	Kim, Han Bok: 1 article (09/2009)
10.	Kim, Kyu Kwang: 1 article (09/2009)

Related Diseases

1.	Renal Cell Carcinoma (Grawitz Tumor) 06/15/1993 - "This study investigates whether or not an interrelationship exists between the expression of resistance-related proteins (P-glycoprotein, glutathione S-transferase, topoisomerase II) and proto-oncogene products (c-fos, c-myc, c-K-ras, epidermal growth factor receptor [EGF-R], and c-neu proteins.) Thirty-eight human renal cell carcinomas of previously untreated patients were analyzed for expression of P-glycoprotein (P-170), glutathione S-transferase-pi (GST-pi), topoisomerase II (Topo II) and proto-oncogene proteins by means of immunohistochemistry. "
2.	Neoplasms (Cancer) 03/18/2016 - "The silencing of the tumor suppressor gene by hypermethylation of the CpG islands and overexpression of proto-oncogene proteins are the main mechanisms in cancers. " 06/15/1993 - "A significant interrelationship between the investigated resistance-related proteins or proto-oncogene proteins and the stage or grading of the tumors was not observed. "
3.	Carcinogenesis 07/01/2002 - "Alteration of ubiquitination and degradation of these proto-oncogene proteins often occurs during tumorigenesis and critically contributes to cell decisions as per proliferation/differentiation and survival/death. "
4.	Optic Nerve Injuries 12/30/1999 - "Distribution of beta-amyloid precursor and B-cell lymphoma proto-oncogene proteins in the rat retina after optic nerve transection or vascular lesion. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 12/30/1999 - "Distribution of beta-amyloid precursor and B-cell lymphoma proto-oncogene proteins in the rat retina after optic nerve transection or vascular lesion. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	ErbB Receptors (EGF Receptor)
3.	Glutathione S-Transferase pi
4.	Member 1 Subfamily B ATP Binding Cassette Transporter
5.	Proto-Oncogene Proteins c-fos (FRAs)
6.	Glutathione Transferase (Glutathione S-Transferase)
7.	Epidermal Growth Factor (EGF)
8.	Type II DNA Topoisomerases (Topoisomerase II)
9.	trioctyl phosphine oxide (TOPO)
10.	Focal Adhesion Protein-Tyrosine Kinases