|1.||Akar, Nejat: 16 articles (08/2013 - 05/2003)|
|2.||De Stefano, Valerio: 15 articles (11/2014 - 05/2002)|
|3.||De Stefano, V: 14 articles (12/2010 - 01/2000)|
|4.||Rosendaal, F R: 14 articles (10/2010 - 01/2000)|
|5.||Mannucci, P M: 13 articles (12/2010 - 09/2000)|
|6.||Martinelli, Ida: 12 articles (12/2015 - 05/2002)|
|7.||Rossi, Elena: 12 articles (10/2013 - 05/2002)|
|8.||Almawi, Wassim Y: 12 articles (08/2013 - 10/2002)|
|9.||Mannucci, Pier Mannuccio: 11 articles (12/2015 - 02/2002)|
|10.||Glueck, Charles J: 11 articles (12/2015 - 06/2002)|
01/01/2015 - "Twenty-four patients with acute bleeding episodes were treated with prothrombin complex concentrate (PCC) at a relative low dose of 30 to -50 U/kg/d and achieved good outcomes without any adverse reaction. "
01/01/2009 - "In bleeding patients, the improvement in coagulation after prothrombin complex concentrate administration was judged to be clinically significant."
01/01/2003 - "He had been managed during his bleeding episodes with prothrombin complex factor concentrates, which became less effective in controlling his bleeding. "
12/01/2013 - "The objective of the present study was to investigate the efficacy of a four-factor prothrombin complex concentrate (Prothromplex, PTX) in shortening prolonged international normalized ratio or controlling life-threatening bleeding. "
09/01/2014 - "[Safety and efficacy of a prothrombin complex concentrate in patients with coagulopathy and hemorrhage]."
|2.||Hemophilia A (Haemophilia)
04/01/2012 - "We report here the case of a boy with hemophilia A and high titers of inhibitors who responded well to prophylactic activated prothrombin complex concentrate (APCC) treatment. "
01/01/1950 - "Studies on serum prothrombin in hemophilia."
12/01/2012 - "Contact-inhibited plasmas from six healthy volunteers, one mild haemophilia A patient, and five patients with heterozygous prothrombin G20210 mutation were assayed. "
10/01/2012 - "Acquired hemophilia successfully treated with activated prothrombin complex concentrate and immunosuppressant combination: a case report."
04/01/2012 - "Cost effectiveness of prophylactic treatment with activated prothrombin complex concentrate in a patient with inhibitor-positive hemophilia A."
05/01/2000 - "Additionally, a bivariate linkage analysis of plasma prothrombin activity and thrombosis significantly improved the linkage signal for prothrombin activity (lod score = 4.7; P = 1.5 x 10(-6)) and provided strong evidence that this QTL has a pleiotropic effect on the risk of thrombosis (lod score = 2.43; P =.0004). "
08/01/2013 - "The objectives of this study were to determine the pathological role of elevated prothrombin in venous and arterial thrombosis in vivo, and distinguish thrombogenic mechanisms in these vessels. "
03/01/2013 - "27 previous studies analyzed the association of BD and thrombosis with the FVL, prothrombin and MTHFR polymorphisms. "
04/01/2006 - "When studies from Turkey were excluded from the meta-analysis, only the prothrombin G20210A mutation was associated with thrombosis."
01/01/2006 - "Mutation screening studies related with thrombosis revealed that prothrombin 20210A allele of the prothrombin gene leads to an increase in plasma prothrombin levels. "
|4.||Liver Diseases (Liver Disease)
06/01/1969 - "[Triple biological test in the diagnosis of certain liver diseases (combined study of prothrombin, fibrinolytic and alexic studies)]."
07/01/2012 - "Prothrombin index slope is an early prognostic marker in patients with severe acute liver diseases."
10/01/2008 - "We conclude that serum Se levels are low in alcoholics; these low values depend more heavily on impaired nutrition but also on liver dysfunction; although low Se levels were associated with a higher mortality, prothrombin activity displaced serum Se when survival was assessed using Cox's regression model."
12/01/2007 - "Therapy with prothrombin-complex concentrate is seldom pursued in patients with liver disease due to high risk of thrombotic complications. "
07/01/2007 - "Postoperative liver dysfunction was defined as an international prothrombin ratio of > or = 1.5. "
|5.||Hypoprothrombinemias (Prothrombin Deficiency)
05/01/1994 - "The hypoprothrombinemia in this syndrome is the result of rapid clearance of prothrombin-antiprothrombin antibody complexes by the reticulo-endothelial system. "
01/15/1990 - "The prothrombin survival time indicates that the hypoprothrombinemia is due to the clearance of the prothrombin-antiprothrombin complex in vivo."
12/01/2000 - "In this study, 13 patients with prothrombin deficiency were screened for the presence of alterations in the prothrombin gene, and nine novel candidate mutations were identified. "
11/01/1947 - "Clinical hypoprothrombinemia; a study of factors A and B of prothrombin."
09/01/2013 - "Two novel mutations in the prothrombin gene identified in a patient with compound heterozygous type 1/2 prothrombin deficiency."
|1.||factor V Leiden
|2.||recombinant FVIIa (rFVIIa)
|4.||Factor V (Coagulation Factor V)
|5.||Factor VIII (Coagulation Factor VIII)
|6.||Factor VIIa (Activated Factor VII)
|7.||Fibrinogen (Factor I)
|8.||Thromboplastin (Tissue Factor)
|2.||Blood Transfusion (Blood Transfusions)
|4.||Minor Surgical Procedures (Minor Surgery)
|5.||Drug Therapy (Chemotherapy)