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Prothrombin (Factor II)

A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Also Known As:
Factor II; Blood Coagulation Factor II; Differentiation Reversal Factor; Factor II, Coagulation; Factor, Differentiation Reversal; II, Coagulation Factor; Coagulation Factor II; Blood-coagulation factor II
Networked: 3772 relevant articles (73 outcomes, 332 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Akar, Nejat: 16 articles (08/2013 - 05/2003)
2. De Stefano, Valerio: 15 articles (11/2014 - 05/2002)
3. De Stefano, V: 14 articles (12/2010 - 01/2000)
4. Rosendaal, F R: 14 articles (10/2010 - 01/2000)
5. Mannucci, P M: 13 articles (12/2010 - 09/2000)
6. Martinelli, Ida: 12 articles (12/2015 - 05/2002)
7. Rossi, Elena: 12 articles (10/2013 - 05/2002)
8. Almawi, Wassim Y: 12 articles (08/2013 - 10/2002)
9. Mannucci, Pier Mannuccio: 11 articles (12/2015 - 02/2002)
10. Glueck, Charles J: 11 articles (12/2015 - 06/2002)

Related Diseases

1. Hemorrhage
2. Hemophilia A (Haemophilia)
3. Thrombosis (Thrombus)
4. Liver Diseases (Liver Disease)
5. Hypoprothrombinemias (Prothrombin Deficiency)

Related Drugs and Biologics

1. factor V Leiden
2. recombinant FVIIa (rFVIIa)
3. Bilirubin
4. Factor V (Coagulation Factor V)
5. Factor VIII (Coagulation Factor VIII)
6. Factor VIIa (Activated Factor VII)
7. Fibrinogen (Factor I)
8. Thromboplastin (Tissue Factor)
9. Serum Albumin
10. Thrombin

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Blood Transfusion (Blood Transfusions)
3. Liver Transplantation
4. Minor Surgical Procedures (Minor Surgery)
5. Drug Therapy (Chemotherapy)