|1.||Nephrotic Syndrome (Syndrome, Nephrotic)
|2.||Hypertension (High Blood Pressure)
|5.||Chronic Kidney Failure (Chronic Renal Failure)
|1.||Remuzzi, Giuseppe: 78 articles (10/2015 - 02/2002)|
|2.||Navis, Gerjan: 58 articles (08/2015 - 02/2002)|
|3.||Kawachi, Hiroshi: 53 articles (10/2015 - 04/2002)|
|4.||Nitta, Kosaku: 39 articles (10/2015 - 05/2002)|
|5.||van Goor, Harry: 39 articles (09/2015 - 03/2002)|
|6.||Vaziri, Nosratola D: 38 articles (01/2016 - 01/2002)|
|7.||Reiser, Jochen: 35 articles (12/2015 - 08/2004)|
|8.||Fujita, Toshiro: 35 articles (02/2014 - 01/2002)|
|9.||Ruggenenti, Piero: 34 articles (10/2015 - 02/2002)|
|10.||Tomino, Yasuhiko: 34 articles (10/2014 - 01/2002)|
07/01/2009 - "Patients with biopsy-proven MN, nephrotic-range proteinuria and clearance of creatinine 50 ml/min or more were included in the study. "
07/01/1994 - "The study subjects comprised 13 patients with biopsy-proven renal disease, a diastolic blood pressure of > 90 mmHg, creatinine clearance of > 60 ml/min and stable proteinuria of > 2.0 g/day. "
06/01/2015 - "The treatment outcome was assessed using proteinuria-based criteria; i.e., complete remission (CR) was defined as urinary protein level of <0.3 g/day or g/g Cr, and incomplete remission type I (ICR-I) was defined as urinary protein level of <1.0-0.3 g/day or g/g Cr, and renal dysfunction was defined as a serum creatinine (Cr) level of 1.5 times the baseline level. "
05/01/2015 - "Similar results were obtained in multivariate analysis: Baseline creatinine elevation (OR 3.62, 95 % CI, 1.59-8.23; p = 0.002) and 24-h proteinuria greater than 1500 mg (OR 3.62, 95 % CI, 1.29-10.13; p = 0.014) were independent predictors of failure to achieve partial or complete remission. "
05/01/2015 - "Elevated creatinine (p = 0.0001) and 24-h proteinuria greater than 1500 mg (p = 0.0011) were basal predictors of failure to attain partial or complete remission by bivariate analysis. "
04/01/2013 - "The primary outcomes included complete or partial remission [complete remission (CR): proteinuria <0.3 g/24 h, with serum albumin ≥ 3.5 g/dl and stable renal function; partial remission (PR): proteinuria between 0.3 and 3.5 g/24 h and a decrease of at least 50 % from the baseline level, with serum albumin ≥ 3.0 g/dl and stable renal function]. "
09/01/2008 - "(1) Complete remission (proteinuria < or = 0.1 g/d or negative by dipstick for 3 consecutive days), partial remission (proteinuria between 0.1 g/d and 50 mg/(kg.d), serum albumin > or = 30 g/L) and resistance to CsA (proteinuria > or = 50 mg/(kg.d), or > or = 3+ by dipstick, after 6 months of CsA treatment over a trough level of 100 microg/L) were observed in 65%, 20% and 15%, respectively. "
04/01/2003 - "At the end of 6 months treatment, 7 (29.2%) patients each had complete remission (absent proteinuria, normal serum albumin) and partial remission (1-2+ proteinuria, normal serum albumin). "
05/01/2013 - "Furthermore, a significantly greater improvement in proteinuria and serum albumin levels was observed in the TAC group compared with the CYC group. "
02/01/2013 - "Proteinuria and serum albumin were significantly improved (42.0% ± 13.2%, P = 0.02; 15.2% ± 4.5%, P = 0.01, respectively) even after the first month of treatment. "
|3.||Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
05/01/2012 - "Highly active anti-retroviral therapy in combination with angiotensin-converting enzyme antagonists is highly effective in decreasing proteinuria and preserving renal function."
01/01/2009 - "One obtained complete remission, two had positive dipstick proteinuria and two needed angiotensin-converting enzyme inhibitors to stay normotensive. "
04/01/1992 - "Patients with recurrent FGS who were treated with ACE inhibitors benefited from a significant reduction of proteinuria. "
01/01/2008 - "Reduction in proteinuria from ARBs and ACE inhibitors is similar, but their combination is more effective than either drug alone. "
05/22/1995 - "In 14 randomized controlled trials, angiotensin-converting enzyme inhibitors caused a greater decrease in proteinuria (pooled mean [95% confidence intervals], -0.51[-0.68 to -0.35], ln [treatment/control]), improvement in glomerular filtration rate (0.13 mL/min per month [0.10 to 0.16 mL/min per month]), and decline in mean arterial pressure (-4.0 mm Hg [-4.9 to -3.0 mm Hg]) compared with controls. "
|4.||Prednisolone (Predate)FDA LinkGeneric
03/01/2011 - "Intensive treatment with a combination of methyl prednisolone pulse therapy and oral prednisolone was successful in achieving complete remission and disappearance of proteinuria in our patient."
05/01/2003 - "Of the 60 patients, 20 cases (33.3%) (Group 1) reached a complete remission of proteinuria by prednisolone alone. "
08/01/1989 - "Clinically, those patients were divided into four stages as follows: (1) untreated nephrotic stage, (2) prednisolone (PSL) treated nephrotic stage, (3) persistent proteinuria stage (incomplete remission, ICR), and (4) complete remission (CR). "
04/03/1987 - "In the 4 cases with complete remission of proteinuria prednisolone was tapered. "
01/01/2006 - "Maximal proteinuria, total amount of BCL, BCL exposure time, and use of prednisolone or other immunosuppressant agents did not significantly influence time until remission. "
|5.||Cyclosporine (Ciclosporin)FDA LinkGeneric
01/01/1996 - "In the third patient, proteinuria relapsed after 9 months of complete remission and persisted in spite of the reintroduction of intravenous cyclosporin. "
03/01/1988 - "Cyclosporine A was started at 7 mg/kg/day and titrated to maintain HPLC level of 100 to 200 ng/ml. Of 20 patients, 14 had a complete remission and the remaining 6 had a reduction in their proteinuria. "
12/01/1987 - "Cyclosporine was started at 7 mg/kg/d and titrated to maintain a serum level of 100 to 200 ng/mL. Of 20 patients, 14 had a complete remission and the remaining six had a reduction in their proteinuria. "
01/01/2011 - "The patient was treated with cyclosporine A (CsA; Neoral®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. "
06/01/1989 - "In the three patients who achieved complete remission, relapse of proteinuria occurred within six weeks of ceasing Cyclosporin. "
01/01/2006 - "Steroids seem to be the best treatment for patients with proteinuria, as drugs in this class ameliorate this symptom and protect against deterioration of renal function. "
05/01/1987 - "Eighteen patients were treated with steroids; ten of these had complete remission of proteinuria and seven a significant reduction of their proteinuria. "
08/01/2010 - "She initially responded well to therapy, but later developed high-grade proteinuria while still on MMF and low-dose steroids. "
01/01/2008 - "The treatment with steroids was the only factor that forecasted a high renal survival (hazard ratio or HR: 0.07, 0.01-0.9) and proteinuria remission (HR: 0.2, 0.04-0.9). "
01/01/2004 - "Cox multivariate regression analyses showed that, in addition to steroids, a low baseline histologic score, a reduction in proteinuria after 6 mo, and no increase in proteinuria during follow-up all were independent predictors of a beneficial outcome. "
|7.||Cyclophosphamide (Cytoxan)FDA LinkGeneric
03/01/1979 - "Full remission in 2 patients in each of the two groups treated with drugs, and diminution of proteinuria in most patients in the cyclophosphamide group showed possible evidence of benefit. "
01/01/2012 - " with intravenous (IV) cyclophosphamide, MMF was as effective in achieving stable kidney function (5 studies, 523 participants: RR 1.05, 95% CI 0.94 to 1.18) and complete remission of proteinuria (6 studies, 686 participants: RR 1.16, 95% CI 0.85 to 1.58). "
01/01/2016 - "His proteinuria and general oedema persisted despite repeated high-dose steroid therapy; however, these clinical symptoms immediately improved after beginning treatment with cyclophosphamide (CyP). "
08/01/2007 - "A 12-month course of MMF decreased proteinuria and improved renal function in the majority of patients, but did not appear as effective or better tolerated than cyclophosphamide. "
08/01/2007 - "Cumulative incidences of remission of proteinuria at 12 months were 66% in the MMF group versus 72% in the cyclophosphamide group (P = 0.3). "
|8.||Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
11/01/2009 - "Proteinuria resolved completely following the initiation of a gluten-free diet, without the use of immunosuppressive therapy and despite tapering of angiotensin-converting enzyme inhibitor. "
07/01/2015 - "Initial therapy consisted of antihypertensive treatment including angiotensin converting enzyme inhibitor (ACEi) leading to blood pressure control and a significant reduction of proteinuria. "
04/27/1992 - "We have previously reported that angiotensin-converting enzyme (ACE) inhibition in Munich Wistar Fromter/Ztm (MWF/Ztm) rats resulted in a significant reduction of proteinuria, in respect to untreated animals, and that treated animals were protected against the development of glomerular sclerotic lesions. "
07/01/2003 - "Remission of nephrotic range proteinuria has also been reported in some patients with type 1 diabetes from the Collaborative Study Group during a median follow-up of 3 years of angiotensin-converting enzyme (ACE) inhibitor administration; no deterioration of renal function was observed in these patients. "
04/01/2005 - "[Influence of angiotensin-converting enzyme gene polymorphism on the anti-proteinuria efficacy of angiotensin-converting enzyme inhibitor in Han nationality of southern Sichuan province in China]."
|9.||Prednisone (Sone)FDA LinkGeneric
01/01/2011 - "After a new relapse, a second 24-month course of MFM and low-dose prednisone produced partial to complete remission of proteinuria with preservation of renal function. "
07/01/1994 - "Alternate day prednisone for up to 6 months may be a reasonable approach since a complete remission in proteinuria was seen in 44% of our treated patients and this response was closely linked to a good long-term prognosis. "
02/20/1988 - "Short-course prednisone therapy consisted of 60 mg/m2 per 24 h until proteinuria had disappeared for 3 days, followed by 40 mg/m2 per 48 h until complete remission had occurred. "
01/01/2015 - "Under treatment with oral prednisone mean eGFR significantly improved from 38 ± 21 ml/min to 57 ± 26 ml/min and proteinuria decreased from 981 ± 304 mg/24 hrs to 176 ± 77 mg/24 hrs at the end of follow-up. "
03/01/2010 - "Prednisone therapy and antihypertensive treatment significantly improved proteinuria and renal function deterioration. "
|10.||Immunoglobulin G (IgG)IBA
07/01/2008 - "Compared with control mice, IL-18R-deficient mice showed a significant reduction of proteinuria, renal pathological findings including glomerular IgG and C3 deposits, and leukocyte infiltrates. "
10/01/2015 - "We compared their clinicopathological findings, including IgG subclass staining, and electron microscopic findings, and evaluated the predictors of proteinuria remission. "
09/01/2009 - "Treatment of NZB/W mice with the beta-galactosylceramide ameliorated lupus disease activity as judged by improvement in proteinuria, renal histopathology, IgG anti-dsDNA antibody formation, and survival. "
02/01/2006 - "Neither absolute levels of urinary IgG, beta(2)M or alpha(1)M at baseline or at 12 months nor the percentage reduction between baseline and 12 months clearly predicted the occurrence of a remission or a relapse to nephrotic range proteinuria. "
09/01/1988 - "A corresponding increase in fractional clearance of anionic (pI 4.5-5.0) over neutral (pI 7.0-7.5) IgG species was observed in patients with subnephrotic-range proteinuria. "
06/01/1996 - "Its appearance was associated with poor prognosis of the graft in most patients, although spontaneous remission of proteinuria is possible."
11/01/2011 - "ACEI/ARBS administration is beneficial in CAI for BP control and significant decrease in proteinuria along with the stabilization of graft function."
01/01/2000 - "A significant reduction in proteinuria without adversely affecting graft function was the main beneficial effect observed. "
10/01/2012 - "In, SRL was well tolerated; conversion to SRL improved graft function with a slight increase in proteinuria."
07/01/2008 - "In addition, the continuous improvement in pancreas transplant alone, offering the opportunity to reduce cardiovascular risk due to proteinuria and reduced glomerular filtration rate (GFR), is rarely appreciated. "
07/01/2003 - "Proteinuria and haematuria improved after treatment. "
11/01/2001 - "The study was stopped prematurely after treatment of the first 24 subjects due to proteinuria in five of the 16 subjects who received systemic bFGF, which exceeded 1000 mg/24 h in four of these five subjects. "
11/01/2015 - "In both the groups, proteinuria decreased significantly 12 months after treatment, and no significant difference in alleviation effects on proteinuria was found between groups. "
07/01/2015 - "Soon after treatment onset there were signs of improvement pertaining to proteinuria and stabilization of renal function. "
07/01/2014 - "The primary outcome was change in 24-hour proteinuria from baseline after treatment. "
|3.||Drug Therapy (Chemotherapy)
09/01/2015 - "The patient's renal function and tubular proteinuria were markedly improved after chemotherapy. "
06/01/2005 - "Improvement in renal function and proteinuria following VAMP chemotherapy correlated with a reduction in circulating light-chain levels. "
01/01/2003 - "Following the serial chemotherapy his proteinuria improved, and M protein became undetectable in both serum and urine. "
01/01/1989 - "The difference between groups 1 and 2 is not simply due to differences in response to chemotherapy, for many group-1 patients achieve improvement in renal function without or before loss of light chain proteinuria. "
01/01/2015 - "12.3% of patients with T2DM tested had a positive proteinuria test for the first screening performed in 1 year after initiation of antidiabetic drug therapy. "
|4.||Transplantation (Transplant Recipients)
02/01/2003 - "High P(alb) is associated with recurrence of FSGS after transplantation, but serial studies of P(alb) activity in patients with native kidney FSGS have not been performed, and the relationship between P(alb) and remission of proteinuria is not known. "
07/01/2015 - "Glomerular enlargement 1 yr after transplantation may be related to improved proteinuria. "
01/01/2007 - "Eighteen months after transplantation the patient keeps haematological remission and normal renal function, without proteinuria.Since"
11/01/2015 - "Recent studies have demonstrated a relationship between low-grade proteinuria and worse graft survival, but this has not been fully studied in expanded criteria donor (ECD) kidney transplant recipients. "
01/01/2013 - "This is the first study to show that increased serum YKL-40 levels are independently associated with proteinuria in renal transplant recipients. "
07/01/2009 - "Plasmapheresis (PP) can reduce proteinuria and even induce complete remission of proteinuria. "
12/01/2012 - "Within 3 weeks of regular anti-TNFα therapy, the patient achieved sustained partial remission of proteinuria, allowing us to wean her off plasmapheresis completely. "
01/01/2013 - "For the treatment of severe HSPN, aggressive therapies including multiple drug combination therapy and plasmapheresis have been shown to be effective in ameliorating proteinuria and histological severity. "
10/01/2011 - "Aggressive therapies for the treatment of severe HSPN, including multiple drug combination therapy and plasmapheresis, have been shown to be effective in ameliorating proteinuria and histological severity. "
09/01/2000 - "Corticosteroid pulse therapy and plasmapheresis were effective in improving proteinuria and reducing protein thrombi. "