Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.

Also Known As:

Antagonist, Protein Synthesis; Antagonists, Protein Synthesis; Inhibitor, Protein Synthesis; Inhibitors, Protein Synthesis; Synthesis Antagonist, Protein; Synthesis Inhibitor, Protein; Protein Synthesis Antagonist; Protein Synthesis Antagonists; Protein Synthesis Inhibitor

Networked: 383 relevant articles (14 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Enzyme Inhibitors: 1659
      - Protein Synthesis Inhibitors: 383

Experts

1.	Nikitin, V P: 12 articles (01/2021 - 11/2007)
2.	Solntseva, S V: 12 articles (01/2021 - 11/2007)
3.	Kozyrev, S A: 8 articles (01/2021 - 11/2007)
4.	Nikitin, P V: 4 articles (01/2021 - 01/2018)
5.	Croons, Valerie: 4 articles (07/2010 - 03/2007)
6.	De Meyer, Guido R Y: 4 articles (07/2010 - 03/2007)
7.	Martinet, Wim: 4 articles (07/2010 - 03/2007)
8.	Dussor, Gregory: 3 articles (01/2021 - 07/2014)
9.	Price, Theodore J: 3 articles (01/2021 - 07/2014)
10.	Ke, Fei: 3 articles (09/2009 - 02/2007)

Related Diseases

1.	Ischemia 07/01/1996 - "The observation that delayed death of CA1 neurons after global ischemia is inhibited by protein synthesis inhibitors suggests that the delayed death of these neurons is an active process that requires new gene expression. " 05/01/1993 - "Activation of programmed cell death has recently been suggested to be involved in the delayed neuronal death of CA1 hippocampal neurons after global ischemia based on protection offered by protein synthesis inhibitors. " 05/29/1992 - "Protein synthesis inhibitors have recently been shown to protect from ischemia-induced neuronal death in the rat hippocampus in vivo. " 11/02/2001 - "In the present study, we tested the hypotheses that delayed administration of a protein synthesis inhibitor would be effective in reducing tissue injury in this slowly evolving ischemic infarction, and that efficacy of this treatment would wane with more prolonged ischemia. " 11/02/2001 - "After mild, but not severe, ischemic insults, cerebral infarction develops slowly and may be treatable with protein synthesis inhibitors, even when treatment is delayed for up to 6 h after the onset of ischemia."
2.	Infarction (Infarctions) 09/12/1997 - "Protein synthesis inhibitor transiently reduces neuronal death in the thalamus of spontaneously hypertensive rats following cortical infarction." 11/02/2001 - "In the present study, we tested the hypotheses that delayed administration of a protein synthesis inhibitor would be effective in reducing tissue injury in this slowly evolving ischemic infarction, and that efficacy of this treatment would wane with more prolonged ischemia. " 08/01/1999 - "In a separate set of similar experiments, we pretreated pig hearts in vivo with the protein-synthesis inhibitor and known activator of SAPK/JNK, anisomycin (AN), and found that this compound also significantly reduced infarct size from 83.4 +/- 2.8.1% to 48.1 +/- 5.1%. " 09/12/1997 - "Using stroke-prone spontaneously hypertensive rats with permanent occlusion of the middle cerebral artery (MCA), we investigated whether the secondary thalamic degeneration following cortical infarction is related to apoptosis, and whether the protein synthesis inhibitor cycloheximide (CHX) ameliorates this degenerative process. " 01/01/2016 - "The SRT was re-trained after stroke while the protein synthesis inhibitor anisomycin (ANI) or saline were injected into the peri-infarct cortex through implanted cannulas. "
3.	Amnesia (Dissociative Amnesia) 09/01/1992 - "In the present study, the effect of subcutaneously administered CER on amnesia induced by protein synthesis inhibitors was examined in passive and active avoidance responses and in the Morris water maze test. " 08/01/1982 - "These studies further document the effects of protein synthesis inhibitors on CA mechanisms and suggest that disruption of CA biochemistry may play a role in the amnesia observed after administration of protein synthesis inhibitors." 01/01/2021 - "The administration of protein synthesis inhibitors and a reminder in the late period after amnesia induction (10 days) did not affect its development or caused a short-term memory recovery. " 01/01/2019 - "The administration of protein synthesis inhibitors led to impairment of amnesia reactivation and to recovery of the state formed before amnesia induction and thus to the recovery of conditioned food aversion memory." 09/06/2016 - "However, the onset of amnesia was delayed if the dose of the inhibitor was reduced or a less potent protein synthesis inhibitor was used. "
4.	Infections 09/01/2008 - "Clinical studies exploring protein synthesis inhibitors as future candidates for treatment of intestinal infections caused by Stx2-producing STEC should therefore include knowledge of the toxin variant in addition to the subtype." 02/06/2013 - "Four immediate-early genes - open reading frames 1, 6A, 127 and 131 - were identified on the basis of expression in the presence of a protein synthesis inhibitor and unique expression profiles during infection in the absence of inhibitor. " 05/01/2003 - "Targeting bacterial virulence: the role of protein synthesis inhibitors in severe infections. " 12/01/1999 - "These cells do not show such apoptotic features when infected with a wild-type virus unless the infections are performed in the presence of a protein synthesis inhibitor. " 05/01/2003 - "Animal studies have demonstrated clindamycin, a protein synthesis inhibitor, to be more effective in treating these severe infections than other more susceptible antimicrobial treatments. "
5.	Neoplasms (Cancer) 10/23/2023 - "Using a transcriptional signature similarity approach, we identified anti-cancer protein synthesis inhibitors as potent modulators of the cardiomyocyte molecular clock. " 12/15/2015 - "Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers." 03/01/2009 - "Protein synthesis inhibitors can suppress the development of thermotolerance in tumor tissues during [corrected] repeated heating. " 08/01/2007 - "Interestingly, the engagement of the receptor by TLR3 agonists can directly inhibit cell proliferation and induce tumor cell death when combined to treatment with either type I IFN or protein synthesis inhibitors. " 10/23/2023 - "Taken together, our observations suggest that the activity spectrum of protein synthesis inhibitors, whose clinical use is contemplated not only in cancers but also in viral infections, must be extended to circadian rhythm disruption, with potential beneficial or iatrogenic effects upon acute or prolonged administration."

Related Drugs and Biologics

1.	Cycloheximide (Cicloheximide)
2.	Homoharringtonine
3.	ethyldeshydroxysparsomycin (EdSm)
4.	Anisomycin
5.	Anti-Bacterial Agents (Antibiotics)
6.	Clindamycin (Cleocin)
7.	RNA (Ribonucleic Acid)
8.	Dactinomycin (Actinomycin)
9.	N-Methylaspartate (NMDA)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Injections
2.	Therapeutics
3.	Aftercare (After-Treatment)
4.	Axotomy
5.	Punctures