|1.||Mochly-Rosen, Daria: 22 articles (10/2011 - 06/2002)|
|2.||Kazanietz, Marcelo G: 18 articles (10/2013 - 01/2002)|
|3.||King, George L: 17 articles (05/2015 - 09/2002)|
|4.||Leitges, Michael: 16 articles (08/2013 - 10/2003)|
|5.||Li, Tao: 14 articles (05/2015 - 06/2006)|
|6.||Strasser, Ruth H: 12 articles (01/2013 - 05/2002)|
|7.||Blumberg, Peter M: 11 articles (06/2014 - 01/2002)|
|8.||Alkon, Daniel L: 10 articles (06/2015 - 04/2008)|
|9.||Larsson, Christer: 10 articles (01/2015 - 03/2003)|
|10.||Jan, Chung-Ren: 10 articles (12/2014 - 02/2003)|
04/01/2007 - "This study was designed to test the hypothesis that preconditioned effluent from rat hearts purified by Sep-Pak C-18 cartridges could induce remote cardioprotection against ischemia/reperfusion (I/R) injury through the activation of protein kinase C signaling pathway. "
12/01/2001 - "The octapeptide (psi)(epsilon)RACK was selected for this study as it is known to exhibit selective epsilon protein kinase C isozyme agonist activity and to reduce ischemia-induced damage in cardiomyocytes. "
02/01/2000 - "In this study, the role of the neuron-specific gamma isoform of protein kinase C (gammaPKC) in reversible focal ischemia was examined using mutant mice in which the gene for gammaPKC was knocked-out (gammaPKC-KO). "
04/01/1998 - "Our recent studies utilizing an in vivo regional ischemia model revealed no changes in the subcellular distribution of protein kinase C (PKC) in dog and rabbit hearts after repeated 5 min episodes of preconditioning ischemia/reperfusion. "
01/01/2014 - "Activation of the diacylglycerol-protein kinase C (DAG-PKC) cascade has been implicated in the cardioprotective effects occurring after ischemia/reperfusion (I/R). "
01/01/2015 - "Protein kinase C-δ (PKC-δ) and PKC-ε are reported to be effective in cancer prevention via S-thiolation-mediated mechanisms. "
07/01/2013 - "In this study, we found that Nanog expression was upregulated by inhibition of protein kinase C (PKC) activity in six human cancer cell lines examined. "
03/01/2013 - "In our previous studies, we reported that protein kinase C ζ (PKCζ) mediated cancer cell chemotaxis by regulating cytoskeleton rearrangement and cell adhesion. "
01/01/2011 - "Protein kinase C was found to be significantly over-expressed in cancer samples compared to adjacent normal cervical tissues by proteomics in our previous study. "
10/15/2009 - "In the present study, we focused on protein kinase C (PKC)alpha, which is hyper-activated in most tumor cells, as a trigger for transgene regulation. "
02/01/2009 - "The aim of the present study was to investigate the roles of protein kinase C (PKC) signal transduction pathway in the 15-hydroxyeicosatetraenoic acid (15-HETE)-induced down-regulation expression of K(V) 1.5, K(V) 2.1 and K(V) 3.4, and pulmonary vasoconstriction under hypoxia. "
05/01/2001 - "The current study was done to test the hypothesis that protein kinase C (PKC) inhibitors prevent the increase in pulmonary vascular resistance and compliance that occurs in isolated, blood-perfused dog lungs during hypoxia. "
07/01/1994 - "These studies indicate that chronic hypoxia impairs the differentiation of 3T3-L1 cells to adipocytes in association with the sustained activation of protein kinase C, which appears to play a role in mediating this process."
06/01/2012 - "Chronic hypoxia differentially up-regulates protein kinase C-mediated ovine uterine arterial contraction via actin polymerization signaling in pregnancy."
05/01/2012 - "Activation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C."
|4.||Diabetic Retinopathy (Retinopathy, Diabetic)
11/01/2009 - "Data from 584 eyes in 340 placebo-treated patients in the 3-years-long Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) trial were used to investigate the relationship between VA and DMO. "
01/01/2007 - "This multicentre, randomised study, named PKC-DRS2 (Protein Kinase C-Diabetic Retinopathy Study 2), was conducted at 70 clinical sites and involved 685 patients with diabetic retinopathy. "
01/01/2004 - "Protein kinase C (PKC) inhibition has been used in therapeutic trials intended to reduce the incidence of proliferative diabetic retinopathy. "
01/31/2014 - "Suppression of protein kinase C-ζ attenuates vascular leakage via prevention of tight junction protein decrease in diabetic retinopathy."
03/01/2011 - "Protein kinase C inhibitors in the treatment of diabetic retinopathy. "
|5.||Hypertension (High Blood Pressure)
06/01/2005 - "The present study examined the role of L-/T-type Ca channels and the interaction between these channels and protein kinase C (PKC) in hypertension. "
01/01/2003 - "The aim of the study was to investigate the role of protein kinase C (PKC) in changes in myofilament Ca(2+)-sensitivity of vascular smooth muscle cells (SMC) in rats at different vasospastic states: hypoxic pulmonary vasoconstriction, genetically determined hypertension, and hypertension resulted from ionizing radiation. "
01/01/2003 - "In the present study, we investigated the role of protein kinase C in the regulation of cholinergic nervous activity in the central nervous system in hypertension. "
10/23/1995 - "The goal of this study was to determine the role of activation of protein kinase C in disruption of the blood-brain barrier during acute hypertension. "
01/01/1990 - "This study was performed to investigate the effects of a specific protein kinase C inhibitor (H-7) on vascular adrenergic transmission in hypertension. "
|2.||Protein Isoforms (Isoforms)
|3.||Protein Kinases (Protein Kinase)
|4.||Type C Phospholipases
|9.||Epidermal Growth Factor (EGF)
|1.||Drug Therapy (Chemotherapy)
|4.||Combination Drug Therapy (Combination Chemotherapy)