Prostatitis

Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.

Also Known As:

Acute Bacterial Prostatitis; Asymptomatic Inflammatory Prostatitis; Chronic Bacterial Prostatitis; Chronic Prostatitis with Chronic Pelvic Pain Syndrome; Acute Bacterial Prostatitides; Asymptomatic Inflammatory Prostatitides; Bacterial Prostatitides, Acute; Bacterial Prostatitides, Chronic; Bacterial Prostatitis, Acute; Bacterial Prostatitis, Chronic; Chronic Bacterial Prostatitides; Inflammatory Prostatitis, Asymptomatic; Prostatitides; Prostatitides, Chronic Bacterial

Networked: 2708 relevant articles (330 outcomes, 455 trials/studies)

Relationship Network

Disease Context: Research Results

Urogenital Diseases: 126
- Genital Diseases: 114
  - Male Genital Diseases: 2
    - Prostatic Diseases: 520
      - Prostatitis: 2708
- Male Urogenital Diseases
  - Male Genital Diseases: 2
    - Prostatic Diseases: 520
      - Prostatitis: 2708

Related Diseases

1.	Pelvic Pain
2.	Pain (Aches)
3.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia)
4.	Infections
5.	Prostatitis

Experts

1.	Nickel, J Curtis: 36 articles (05/2017 - 08/2002)
2.	Shoskes, Daniel A: 28 articles (01/2021 - 07/2002)
3.	Schaeffer, Anthony J: 28 articles (11/2020 - 08/2002)
4.	Zhang, Li: 20 articles (10/2022 - 01/2014)
5.	Cai, Tommaso: 19 articles (09/2021 - 12/2006)
6.	Perletti, Gianpaolo: 16 articles (09/2021 - 05/2007)
7.	Weidner, W: 16 articles (12/2014 - 02/2000)
8.	Naber, K G: 16 articles (11/2011 - 03/2000)
9.	Magri, Vittorio: 15 articles (07/2021 - 06/2005)
10.	Wagenlehner, Florian M E: 15 articles (01/2019 - 08/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Prostatitis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 05/06/2014 - "Our meta-analysis reveals that antibiotics are not beneficial in the management of category III prostatitis. " 05/06/2014 - "To determine whether antibiotics are beneficial in the management of category III prostatitis. " 05/06/2014 - "Antibiotics are not beneficial in the management of category III prostatitis: a meta analysis." 01/01/2020 - "Repeat biopsy seems to increase the risk of acute prostatitis, while the use of antibiotics effective for anaerobic pathogens seems not to be essential yet." 12/01/1986 - "Although Cephem antibiotics are transferred to the prostatic fluid in relatively low levels, they are clinically effective for bacterial prostatitis. "
2.	Ciprofloxacin (Cipro)FDA LinkGeneric 08/01/2002 - "Our model implies that ciprofloxacin 500 mg twice daily for 28 days appears to be the most cost effective treatment for chronic bacterial prostatitis. " 08/01/2002 - "Twice daily ciprofloxacin @ 500 mg for 28 days proved to be the most cost effective treatment for chronic bacterial prostatitis. " 06/01/2001 - "Ciprofloxacin has been shown to be effective in the treatment of chronic bacterial prostatitis caused by Escherichia coli. " 09/01/2003 - "Tc-99m ciprofloxacin imaging is helpful in the differential diagnosis of prostatitis syndrome." 01/01/2016 - "The general aim of this study is to investigate the protective effect of Korean red ginseng (KRG) on prostatitis in male rats treated with ciprofloxacin (CIPX). "
3.	Levofloxacin (Levaquin)FDA Link 04/01/2007 - "[Longqingpian combined with levofloxacin highly effective for type IIIA prostatitis]." 04/01/2007 - "To study the therapeutic efficacy of Longqingpian combined with Levofloxacin on Type IIIA prostatitis. " 06/01/2010 - "To compare the safety and efficacy of levofloxacin 750 mg QD for 2 weeks or levofloxacin 750 mg QD for 3 weeks to levofloxacin 500 mg QD for 4 weeks in treating chronic bacterial prostatitis (CBP). " 06/01/2010 - "Safety and efficacy of levofloxacin 750 mg for 2 weeks or 3 weeks compared with levofloxacin 500 mg for 4 weeks in treating chronic bacterial prostatitis." 01/01/2019 - "Levofloxacin for NIH Category II Chronic Bacterial Prostatitis: A Real-Life Study."
4.	Capsules (Microcapsules)IBA 11/01/2023 - "Our study indicates that the SSTL capsule is an effective treatment for prostatitis." 05/01/2014 - "[Therapeutic efficacy of compound Xuanju capsule on autoimmune prostatitis in rats: an experimental study]." 02/01/2010 - "The purpose of this study was to investigate the therapeutic efficacy of Qianlie Jiedu Capsule for chronic prostatitis (CP) by the randomized double-blind controlled method. " 06/01/2013 - "[Therapeutic efficacy of compound Xuanju capsule on type III prostatitis]." 09/01/1998 - "Prostatitis decoction (capsule) was effective in treating chronic prostatitis."
5.	FluoroquinolonesIBA 01/01/2002 - "Fluoroquinolones are now most effective in management of acute or exacerbation of chronic bacterial prostatitis. " 10/01/2006 - "The high tissue/ serum ratio and the extended antibacterial spectrum suggests active concentration in the prostate which may translate into increased efficacy compared to group 2 and 3 fluoroquinolones in the treatment of chronic bacterial prostatitis." 12/01/2011 - "Prophylactic fluoroquinolone is still effective in preventing acute bacterial prostatitis after TRUS-guided prostate biopsy. " 01/01/2002 - "Fluoroquinolones are safe and effective in managing chronic bacterial prostatitis. " 04/09/2023 - "To evaluate the efficacy of Flogofilm® in association with fluoroquinolones in patients with chronic bacterial prostatitis (CBP). "
6.	VitaprostIBA 03/01/2006 - "We studied efficacy of a new cytomedine drug--vitaprost--in 98 patients with chronic abacterial prostatitis. " 03/01/2020 - "to study the frequency and type of sexual disorders in patients with chronic prostatitis (CP) and to evaluate the efficiency of Vitaprost and the biologically active complex NeuroDose in treating sexual dysfunctions. " 03/01/2015 - "The aim of the study was to assess the effect of a combined preparation of Vitaprost on blood supply and microcirculation in the prostate gland in 35 patients with chronic infectious urethral prostatitis. " 11/01/2013 - "[Effectiveness of Vitaprost Plus in the treatment of patients with chronic bacterial prostatitis]." 07/01/2012 - "[Efficiency of vitaprost in patients with chronic prostatitis]."
7.	Tadalafil (Cialis)FDA Link 10/23/2019 - "In this study, focused on the prostate, we examined the effect of tadalafil on the pathological changes and inflammatory factors in a rat nonbacterial prostatitis (NBP) model. " 12/01/2018 - "Twenty patients affected by chronic prostatitis according EAU (European Association of Urology) guidelines were evaluated for once-daily 5 mg tadalafil; 14 patients were eligible for the study. " 10/23/2019 - "Forty ten-month-old male Wistar rats were divided into nonbacterial prostatitis (NBP), NBP with tadalafil treatment (NBP-tadalafil), control, and control treated with tadalafil (control-tadalafil) groups (n = 10 per group). " 10/01/2022 - "Comment on "Tadalafil monotherapy in management of chronic prostatitis/chronic pelvic pain syndrome: a randomized double‑blind placebo controlled clinical trial"." 10/01/2022 - "Correction to: Tadalafil monotherapy in management of chronic prostatitis/chronic pelvic pain syndrome: a randomized double-blind placebo controlled clinical trial."
8.	Prostate-Specific Antigen (Semenogelase)IBA 03/01/2005 - "The symptoms were improved by medication for prostatitis, and prostate-specific antigen (PSA) level of 22.6 ng/ml descreased to 9.9 ng/ml. It remained between 7.2 ng/ml and 9.9 ng/ml for 2 years. " 06/01/2016 - "The aim of this study was to determine the duration that antibiotherapy should have in order to make total prostate-specific antigen (tPSA) levels decrease to normal ranges in patients without prostatitis symptoms but with total PSA levels around 4.01-9.9 ng/dL. " 01/01/2013 - "The aim of the study was to compare the yield of mean platelet volume (MPV), total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), f/t PSA ratio and complex prostate specific antigen (cPSA) in patients with prostatitis. " 08/01/2023 - "Extremely Elevated Prostate-Specific Antigen in Acute Prostatitis: A Case Report." 04/01/2022 - "Participants were evaluated with National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Scores (IPSS), International Index of Erectile Function (IIEF), four-glass test, uroflowmetry, and prostate-specific antigen assessments at baseline and at Week 4, and Week 12. "
9.	ZincIBA 06/01/2002 - "Our results suggest that the local application of zinc to the prostate may be a new treatment for chronic bacterial prostatitis at the point of its pathogenesis." 05/01/2004 - "To study the efficacy of biological organic zinc in the treatment of chronic bacterial prostatitis (CBP). " 10/01/2013 - "to investigate the efficacy of zinc supplementation in chronic prostatitis treatment. " 10/01/2013 - "The efficacy of zinc for treatment of chronic prostatitis." 01/01/2015 - "Further studies with larger sample sizes are needed to better illuminate the negative impact of chronic prostatitis on zinc concentrations."
10.	Tamsulosin (Flomax)FDA LinkGeneric 01/01/2014 - "Addition of tamsulosin to the LVX regimen was beneficial for patients with bacterial prostatitis because tamsulosin could increase the maximal concentration of LVX in prostatic tissue. " 03/01/2008 - "The efficacy of tamsulosin in the treatment of chronic non-bacterial prostatitis was evaluated in a randomized clinical observation of 105 male outpatients conducted for 90 days. " 02/01/2017 - "This multicenter randomized controlled clinical trial included 478 patients with type Ⅲ prostatitis, 290 in the trial group and 188 as controls, the former treated with BDG at 200 ml bid and the latter with tamsulosin hydrochloride sustainedrelease capsules at 0.2 mg qd, both for 4 weeks. " 12/01/1999 - "Terazosine and tamsulosin in non bacterial prostatitis: a randomized placebo-controlled study." 01/01/2023 - "We retrospectively analyzed the clinical data on 51 cases of intractable type ⅢB prostatitis treated from October 2020 to October 2022, which were randomly assigned to receive Tamsulosin medication (the control group, n = 24) or pelvic floor muscle rehabilitation training and psychological nursing in addition (the intervention group, n = 27), all for 8 weeks. "

Therapies and Procedures

1.	Therapeutics 10/01/2016 - "Fifty-five out of 70 patients (78.6%) showed eradication of the causative pathogen, and a significant reduction of the NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) total score from a baseline median value of 21 to 14 at the end of therapy, and to 9 and 8 at 6-month and 12-month follow-up assessments, respectively. " 05/01/1999 - "Antimicrobial therapy is effective in the majority of men with acute and chronic bacterial prostatitis (CBP). " 05/01/1998 - "Antimicrobial therapy is effective in the majority of men with acute and chronic bacterial prostatitis (CBP). " 11/01/1990 - "Antimicrobial therapy is effective in the majority of men with acute or chronic bacterial prostatitis. " 01/01/2019 - "On the basis of these results, XLQ ® can be developed as an effective and safe therapy for chronic prostatitis."
2.	Extracorporeal Shockwave Therapy 01/01/2020 - "After evaluating clinical trials and demonstrating the efficacy of chronic non-bacterial prostatitis treatment, it remains of clinical importance to continue studies on the use of low-energy extracorporeal shock wave therapy (ESWT) in men. " 11/01/2013 - "The randomized controlled study was aimed to the evaluation of the efficacy of extracorporeal shock wave therapy (ESWT) compared with drug treatment in patients with chronic prostatitis category IIIB. " 02/01/2017 - "Long term efficacy of extracorporeal shock wave therapy [ESWT] for treatment of refractory chronic abacterial prostatitis." 02/01/2022 - "Efficacy and safety evaluation of low-intensity extracorporeal shock wave therapy on prostatitis-like symptoms: An open-label, single-arm trial." 03/01/2020 - "the aim of this study was to evaluate the effect of extracorporeal shockwave therapy on CPPS due to non bacterial prostatitis. "
3.	Aftercare (After-Treatment) 09/01/2005 - "The prostatitis symptoms and sexual dysfunction were improved obviously after treatment in the two groups, but compared with the control, more marked improvement was observed in the combined psychologic treatment group (P <0.01). " 06/12/2023 - "Before treatment, after treatment and in follow-up of 24 weeks after treatment completion, the National Institutes of Health-chronic prostatitis symptom index (NIH-CPSI) score and urinary flow rate were observed in both groups; the clinical efficacy and safety were evaluated. " 01/01/2023 - "Patients were evaluated by Turkish-validated National Health Institute Chronic Prostatitis Symptom Index (NIH-CPSI) and visual analogue scale (VAS) initially and after treatment. " 12/01/2022 - "The National Institutes of Health-Chronic Prostatitis Symptom Index was used to evaluate prostatitis in the 2 groups before and at 4 weeks after treatment. " 04/25/2022 - "The changes in the scores of National Institute of Health chronic prostatitis symptom index (NIH-CPSI), international index of erectile function (IIEF), visual analogue scale (VAS) were evaluated befroe and after treatment. "
4.	Transurethral Resection of Prostate (TURP) 01/01/2019 - "In SCI male patients with rUTIs and suspected chronic prostatitis, TURP may be a valuable treatment option once all predisposing factors have been remediated." 01/01/1975 - "From the Stamey localisation studies and cultures of the tissue obtained at transurethral prostatectomy a diagnosis of bacterial prostatitis was made in 50%, of which half were Staphylococcus albus and half were well recognised urinary pathogens. " 01/01/1975 - "A clinical diagnosis of chronic prostatitis was made on 105 adult males who were subsequently admitted and investigated by Stamey localisation techniques, psychological questionnaires, urine flow studies, cysto-urethroscopy and prostatic biopsy or transurethral prostatectomy. " 03/01/2023 - "Our aim was to evaluate the association between histological prostatitis and adverse post-operative urinary outcomes following TURP procedure. " 03/01/2023 - "The association between histological prostatitis found at transurethral resection of the prostate (TURP) and adverse post-operative urinary outcomes is not clearly defined. "
5.	Massage (Zone Therapy) 08/01/2009 - "In this study we prospectively evaluate the efficacy of examination of post-prostatic massage urine for prediction of asymptomatic prostatitis in biopsies. " 12/01/2018 - "We found no information regarding adverse events, sexual dysfunction or quality of life.4. Prostatic massage: (two studies, 115 participants) based on short-term follow-up, we are uncertain whether the prostatic massage reduces or increases prostatitis symptoms compared with control (very low QoE). " 01/26/2018 - "We found no information regarding adverse events.6. Prostatic massage: (two studies, 115 participants) based on short-term follow-up, we are uncertain whether the prostatic massage reduces or increases prostatitis symptoms compared with control (very low QoE). " 12/01/2021 - "In patients with chronic bacterial prostatitis, a predominance of anaerobes or a combination of aerobes and anaerobes in a titer of ≥103 colony-forming units per mL in post-massage urine is associated with worse clinical status." 01/01/2021 - ": Patient evaluation should consist of history and physical examination (with focus on the genitourinary and digital rectal examination), laboratory tests (including urine analysis and urine culture with consideration of pre- and post-prostate massage urine cultures), post-void residual, and questionnaires including the National Institutes of Health Chronic Prostatitis Symptoms Index, which helps assess symptom severity and treatment response. "