|1.||Sakai, Yoshiki: 16 articles (07/2015 - 12/2005)|
|2.||Okajima, Kenji: 14 articles (06/2010 - 03/2002)|
|3.||Barst, Robyn J: 13 articles (02/2015 - 11/2002)|
|4.||Seeger, W: 12 articles (12/2010 - 03/2000)|
|5.||Harada, Naoaki: 12 articles (06/2010 - 03/2002)|
|6.||FitzGerald, Garret A: 11 articles (04/2014 - 03/2002)|
|7.||Keith, Robert L: 11 articles (02/2013 - 05/2004)|
|8.||Seeger, Werner: 11 articles (10/2011 - 04/2002)|
|9.||Narumiya, Shuh: 11 articles (08/2010 - 10/2002)|
|10.||Sitbon, Olivier: 10 articles (12/2015 - 03/2002)|
|1.||Pulmonary Hypertension (Ayerza Syndrome)
06/01/2004 - "We describe a patient whose severe pulmonary hypertension following mitral valve replacement was treated successfully with continuous intravenous epoprostenol."
12/19/2000 - "Prostacyclin has proved to be a beneficial treatment for patients with severe pulmonary hypertension. "
06/01/1995 - "This might be explained by the fact that the reduction of pulmonary vascular resistance during PGI2 amounted to only 65% of the effect of NO. In summary, both inhaled NO and PGI2-aerosol showed beneficial effects on RV performance and may prove helpful in the treatment of acute pulmonary hypertension."
09/01/2010 - "Inhaled prostacyclin has been found to be effective in some patients with pulmonary hypertension. "
07/01/2008 - "Exogenous prostacyclin is effective in reducing pulmonary vascular resistance in some forms of human pulmonary hypertension (PH). "
05/01/1984 - "Prostacyclin may be an effective agent for prevention of ischemia in all areas of the GI tract prone to stress ulceration."
08/01/1986 - "PGI2 ameliorates myocardial injury and reduces functional impairment produced by ischemia in doses that elicit vasodilation. "
02/01/2003 - "Many studies have shown the beneficial effects of prostacyclin in ischemia and reperfusion. "
03/01/1989 - "This study therefore shows that PGI2 at critical low concentrations can depress left ventricular recovery following total ischemia. "
01/01/1989 - "To study this hypothesis, thromboxane and prostacyclin were measured by RIA after incubation of liver tissues removed during and after an ischemia of 90 min in male Wistar rats. "
09/01/2015 - "RIAD-Arg11 caused a significant reduction in raft-localized phosphoGPIbβ and diminished the ability of PGI2 to regulate VWF-mediated aggregation and thrombus formation in vitro. "
01/01/1988 - "Efficacy of PGI2 in preventing thrombosis of the extracorporeal circuit was demonstrated in all cases with a dose of 4 ng/kg/min. HF performances remained unaffected whatever antithrombotic agent was used. "
03/21/2002 - "Animal studies show that inhibition of prostacyclin activity does not lead to spontaneous thrombosis but may increase response to thrombotic stimuli. "
01/01/1981 - "The use of prostacyclin in preventing occlusion of microvascular anastomoses by platelet thrombus: an experimental study in rats."
05/01/2014 - "Bdkrb2(-/-) mice are best characterized and they are protected from thrombosis through over expression of components of the renin angiotensin system (RAS) leading to elevated prostacyclin with vascular and platelet inhibition. "
07/01/1985 - "Moreover, during hypoxia, associated with the increased PPA and PVR, the administration of PGI2 appears to be particularly effective in "normalizing" these parameters."
10/01/2001 - "Inhaled PGI2 can be useful in the treatment of patients with PHT and severe hypoxia. "
03/01/2000 - "This study was carried out to determine the efficacy of and dose-response relationships to inhaled aerosolized prostacyclin (IAP), when used as a selective pulmonary vasodilator (SPV) in patients with severe hypoxemia due to ARDS. "
12/01/1992 - "The goal of our study was to determine the association of TXA2 and PGI2 levels with hypoxemia in infants born with CDH. "
02/01/2014 - "H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2."
11/25/2002 - "Our study shows that antithrombin did not reduce ischemia/reperfusion injury in the isolated heart, and prostacyclin is not significantly released following antithrombin treatment. "
12/01/2001 - "This study investigates the effects of a prostacyclin analogue (OP-2507) on hepatic ischemia-reperfusion injury. "
10/30/2001 - "Roles of prostaglandin I(2) and thromboxane A(2) in cardiac ischemia-reperfusion injury: a study using mice lacking their respective receptors."
12/01/1998 - "This study investigated the effects of a prostacyclin analogue (OP-2507) on hepatic ischemia-reperfusion injury. "
11/25/2002 - "We investigated the influence of antithrombin on ischemia/reperfusion injury and prostacyclin release in the isolated rat heart. "
|3.||Nitric Oxide (Nitrogen Monoxide)
|5.||Aspirin (Acetylsalicylic Acid)
|6.||Idiopathic pulmonary hypertension
|8.||Thromboxane A2 (A2, Thromboxane)
|10.||Vasodilator Agents (Vasodilators)
|1.||Transplantation (Transplant Recipients)
|5.||Artificial Respiration (Mechanical Ventilation)