Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)

4051  relevant articles (145 outcomes, 437 trials/studies) found for this Bio-Agent

Cyclooxygenase; Cyclo-Oxygenase; Prostaglandin-Endoperoxide Synthase; Arachidonic Acid Cyclooxygenase; Cyclooxygenases; Hydroperoxide Cyclase; PGH2 Synthetase; Prostaglandin Cyclo-Oxygenase; Prostaglandin Cyclooxygenase; Prostaglandin Endoperoxide Synthetase; Prostaglandin G-H Synthase; Prostaglandin H2 Synthetase; Prostaglandin Synthetase; Cyclase, Hydroperoxide; Cyclo Oxygenase; Cyclo-Oxygenase, Fatty Acid; Cyclo-Oxygenase, Prostaglandin; Cyclooxygenase, Arachidonic Acid; Cyclooxygenase, Prostaglandin; Endoperoxide Synthetase, Prostaglandin; Fatty Acid Cyclo Oxygenase; G-H Synthase, Prostaglandin; Prostaglandin Cyclo Oxygenase; Prostaglandin Endoperoxide Synthases; Prostaglandin G H Synthase; Synthase, PGH; Synthase, Prostaglandin; Synthase, Prostaglandin G-H; Synthase, Prostaglandin H; Synthase, Prostaglandin-Endoperoxide; Synthases, Prostaglandin-Endoperoxide; Synthetase, PGH2; Synthetase, Prostaglandin; Synthetase, Prostaglandin Endoperoxide; Synthetase, Prostaglandin H2; Fatty Acid Cyclo-Oxygenase; PGH Synthase; Prostaglandin H Synthase; Prostaglandin Synthase; (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nair, Muraleedharan G: 6 articles (10/2007 - 01/2003)
2.	Konturek, P C: 6 articles (12/2004 - 09/2000)
3.	Konturek, S J: 6 articles (12/2004 - 09/2000)
4.	Hahn, E G: 6 articles (12/2004 - 09/2000)
5.	Sharma, Sherven: 4 articles (01/2008 - 01/2003)
6.	Zhang, Yanjun: 4 articles (07/2006 - 01/2003)
7.	Kumar, Dinesh: 3 articles (03/2008 - 03/2005)
8.	Tandan, Surendra Kumar: 3 articles (03/2008 - 03/2005)
9.	Prakash, Vellanki Ravi: 3 articles (03/2008 - 03/2005)
10.	Krishna, Vamsi: 3 articles (03/2008 - 03/2005)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2006 - "BACKGROUND: There is controversy on the safety of inhibitors of cyclooxygenase administered at high doses; however, these drugs have been reported to be effective in the prevention of a variety of human cancers" 10/15/2002 - "A number of studies have shown that cyclooxygenase (COX)-2 is overexpressed in many forms of human tumors, suggesting that COX-2 inhibition may be useful in the treatment of cancer" 03/01/2004 - "Accordingly, observations in animal experiments and short-term clinical trials in selected groups of cancer patients, have implied that cyclo-oxygenase (COX) blockade can improve host metabolism and well-being, and long-term COX-treatment of unselected groups have implied improved survival" 10/01/2005 - "Cyclooxygenase (COX) inhibitors have demonstrated efficacy in models of human cancer but the relevant mechanisms have not all been elucidated" 12/01/2004 - "Inhibition of reflux-stimulated inflammatory changes, for example by inhibiting cyclooxygenase, holds promise for decreasing cancer progression" Order ALL the reference details at left...
2.	Pain (Aches) 07/01/2006 - "Selective inhibition of the cyclooxygenase (COX)-2 enzyme appeared to offer patients similar pain relief with an improved adverse-effect profile" 09/01/2007 - "Brain imaging of analgesic and antihyperalgesic effects of cyclooxygenase inhibition in an experimental human pain model: a functional MRI study." 10/01/2004 - "The present study was undertaken to determine the effects of cyclooxygenase (COX) inhibitors on the development of neuropathic pain in rats following chronic constriction injury (CCI)" 08/19/2008 - "Thus, TRPA1 antagonism may contribute to suppress pain evoked by PG metabolites without the adverse effects of inhibiting cyclooxygenases." 01/01/2008 - "OBJECTIVE: To determine the effect of 3 different cyclo-oxygenase (COX) inhibitors on primary dysmenorrheic pain" Order ALL the reference details at left...
3.	Inflammation 09/01/1992 - "The study suggests that long-term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta-articular bone secondary to synovial inflammation." 10/15/2008 - "Our previous studies demonstrate that the cyclooxygenase (COX) metabolic pathway is actively involved in allergic responses and COX inhibition increases allergic airway inflammation in a STAT6-independent fashion" 11/01/2007 - "The present study is the first to investigate the participation of central cyclooxygenase (COX) pathways in modulating the antinociceptive effects of intracisternally administered cannabinoid on nociception induced by inflammation of the temporomandibular joint (TMJ) in freely moving rats" 06/01/2005 - "So far, clinical trials designed to inhibit inflammation or cyclooxygenase activity have failed in the treatment of AD patients" 08/19/2003 - "BACKGROUND: Prostanoid synthesis by the cyclooxygenase (COX)-2 pathway plays an important role in inflammation, and recent studies have shown the presence of COX-2 in the normal rat lung" Order ALL the reference details at left...
4.	Osteoarthritis 08/15/2005 - "Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis." 11/01/2003 - "Comparing the efficacy of cyclooxygenase 2-specific inhibitors in treating osteoarthritis: appropriate trial design considerations and results of a randomized, placebo-controlled trial." 12/01/1999 - "OBJECTIVES: To compare prostaglandin production and cyclooxygenase activity in high-density primary cultures of chondrocytes from patients with osteoarthritis and from healthy controls" 10/01/1991 - "Predispositions to prescribe a pure analgesic, a cyclooxygenase inhibiting nonsteroidal antiinflammatory drug (NSAID) or a nonacetylated salicylate for a fictitious, uncomplicated case of osteoarthritis (OA) were surveyed in a sample of 152 community based primary care practitioners who had been characterized with respect to medical education and practice characteristics" 02/01/1991 - "Select classes of nonsteroidal antiinflammatory drugs (NSAID), independent of their cyclooxygenase suppressing property, may potentially regulate pathophysiologic mechanisms operative in accelerated cartilage catabolism occurring in osteoarthritis (OA)" Order ALL the reference details at left...
5.	Rheumatoid Arthritis 03/01/1998 - "The inhibition of cyclooxygenase may not be essential for their anti-rheumatic activity, since compounds with strong anti-denaturant properties and devoid of anti-inflammatory activity were shown to be effective in an experimental model of rheumatoid arthritis" 06/01/2004 - "OBJECTIVE AND DESIGN: The aim of this study was to confirm the involvement of cyclooxygenase (COX)-1 in rheumatoid arthritis (RA)" 07/01/1997 - "We reviewed data suggesting the hypothesis that specific inhibition of the inducible isoform of cyclooxygenase, COX-2, would provide therapeutic benefit in patients with rheumatoid arthritis (RA) with less gastrointestinal toxicity and presented the results of a therapeutic trial to test this hypothesis" 07/01/2007 - "Effects of selective and non-selective cyclo-oxygenase inhibition on endothelial function in patients with rheumatoid arthritis." 06/01/2003 - "Recent evidence suggests that cyclooxygenase (COX)-2 is a mediator of angiogenesis, and COX-2 activity is known to be upregulated in the rheumatoid arthritis (RA) synovium" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Indomethacin (Indometacin)
2.	Lipoxygenase (Lipoxygenase-1)
3.	Aspirin (Acetylsalicylic Acid)
4.	Arachidonic Acid (Vitamin F)
5.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
6.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
7.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
8.	celecoxib (Celebrex)
9.	Lipoxygenase Inhibitors
10.	Prostaglandins

Related Therapies and Procedures

1.	Analgesia
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Intrauterine Devices (Intrauterine Device)
4.	Therapeutics
5.	Thoracotomy