Dextropropoxyphene (Darvon)

A narcotic analgesic structurally related to METHADONE. Only the dextro-isomer has an analgesic effect; the levo-isomer appears to exert an antitussive effect.

Also Known As:

Darvon; Propoxyphene; Propoxyphene Hydrochloride; Propoxyphene Hydrochloride, (R*,R*)-(+-)-Isomer; Propoxyphene Hydrochloride, (R-(R*,R*))-Isomer; Propoxyphene Hydrochloride, (R-(R*,S*))-Isomer; Propoxyphene Hydrochloride, (S-(R*,R*))-Isomer; Propoxyphene Maleate, (+)-Isomer; Propoxyphene Phosphate, (S-(R*,S*))-Isomer; Propoxyphene Sulfate, (S-(R*,S*))-Isomer; D Propoxyphene; Hydrochloride, Propoxyphene; D-Propoxyphene; Benzeneethanol, alpha-(2-(dimethylamino)-1-methylethyl)-alpha-phenyl-, propanoate (ester), (S-(R*,S*))-

Networked: 382 relevant articles (19 outcomes, 33 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Bertin, Philippe: 3 articles (10/2014 - 09/2006)
2.	Gunnell, David: 2 articles (01/2019 - 01/2012)
3.	Hawton, Keith: 2 articles (01/2019 - 01/2012)
4.	Kapur, Navneet: 2 articles (01/2019 - 01/2012)
5.	Wells, Claudia: 2 articles (01/2019 - 01/2012)
6.	Hawthorne, W: 2 articles (06/2015 - 10/2014)
7.	Lam, V: 2 articles (06/2015 - 10/2014)
8.	Tran, H: 2 articles (06/2015 - 10/2014)
9.	Tran, K: 2 articles (06/2015 - 10/2014)
10.	Turingan, I: 2 articles (06/2015 - 10/2014)

Related Diseases

1.	Pain (Aches) 02/01/1990 - "Smokers experience less pain relief with propoxyphene than do nonsmokers. " 08/01/1989 - "Practitioners prescribing propoxyphene acutely for pain should be aware of this significant interaction." 02/18/1984 - "Dextropropoxyphene, which had a marginal effect on pain score, led to a more significant effect on patient well-being, particularly when it was the first drug given in the sequence. " 01/01/1982 - "Multivariate contingency table analysis revealed that the drug bulletin significantly (p less than or equal to 0.05) reduced the prescribing of propoxyphene hydrochloride across both the minor and moderate pain categories. " 05/01/1978 - " A propoxyphene preparation was allowed for those receiving little or no relief of severe pain. "
2.	Osteoarthritis 01/01/1983 - "Long-term comparison of suprofen and propoxyphene in patients with osteoarthritis." 01/01/1983 - "It was concluded that suprofen, 200 mg q.i.d., is comparable in terms of efficacy to propoxyphene, 65 mg q.i.d., in relieving pain due to osteoarthritis." 02/18/1984 - "The analgesic effects of dextropropoxyphene and paracetamol and that of a combination of the two drugs were assessed in 24 patients who suffered from either rheumatoid arthritis or osteoarthritis. " 01/01/1983 - "The analgesic efficacy and safety of suprofen, 200 mg q.i.d., and propoxyphene, 65 mg q.i.d., were compared in 114 patients with chronic pain due to osteoarthritis. " 11/01/1992 - "Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis."
3.	Postoperative Pain 08/01/1973 - "A controlled study of dextropropoxyphene 1-carboxymethyl-3,7-dimethylxanthine (Z867) IN POSt-operative pain." 04/01/1998 - "Single-dose dextropropoxyphene in post-operative pain: a quantitative systematic review." 01/01/2000 - "For a single dose of dextropropoxyphene 65 mg in postoperative pain the NNT for at least 50% pain relief was 7.7 (95% confidence interval 4.6 to 22) when compared with placebo over 4-6 hours. " 04/01/1998 - "For a single dose of dextropropoxyphene 65 mg in post-operative pain the number-needed-to-treat for at least 50% pain relief was 7.7 (95% confidence interval 4.6 to 22) when compared with placebo over 4-6 h. " 01/01/2000 - "Single dose dextropropoxyphene, alone and with paracetamol (acetaminophen), for postoperative pain."
4.	Sprains and Strains (Sprain) 01/01/1978 - "A preliminary double-blind, randomized trial was carried out in general practice to compare the efficacy of treatment with diflunisal (500 mg) twice daily and a combination of dextropropoxyphene (65 mg) plus paracetemol (650 mg) 3-times daily for 3 days in relieving pain associated with strains and sprains. " 02/01/1980 - "Diflunisal is comparable with glafenine in pain and with propoxyphene/paracetamol combinations and oxyphenbutazone in pain and in musculoskeletal strains and sprains. "
5.	Knee Osteoarthritis 11/01/1992 - "A double-blind randomized parallel group trial was undertaken to compare the acceptability and efficacy of 2 forms of analgesic treatment, DI-Antalvic (Houde Laboratories, Puteaux, France) (30 mg dextropropoxyphene and 400 mg paracetamol per capsule) and Efferalgan-Codeine (UPSA Laboratories, Rueil Malmaison, France) (30 mg codeine and 500 mg paracetamol per tablet) prescribed for 1 week at doses of 6 capsules/day and 6 tablets/day, respectively, in 141 outpatients with active osteoarthritis of the knee or hip. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Acetaminophen (Paracetamol)
3.	Codeine (Codeine Phosphate)
4.	Tramadol (K315)
5.	Tablets
6.	Ibuprofen (Motrin)
7.	Diflunisal (Dolobid)
8.	Naproxen (Naprosyn)
9.	Opioid Analgesics (Opioids)
10.	dihydrocodeine

Related Therapies and Procedures

1.	Therapeutics
2.	Episiotomy
3.	Orthopedic Procedures
4.	Hysterectomy
5.	Analgesia