Propantheline (Propantheline Bromide)

A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.

Also Known As:

Networked: 113 relevant articles (8 outcomes, 15 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Chen, Shih-Yu: 1 article (01/2019)
2.	Kisely, Steve: 1 article (01/2019)
3.	Ravindran, Gopi: 1 article (01/2019)
4.	Siskind, Dan: 1 article (01/2019)
5.	Zhang, Qichen: 1 article (01/2019)
6.	Baron, Todd H: 1 article (10/2018)
7.	Desai, Chirag S: 1 article (10/2018)
8.	Khan, Khalid M: 1 article (10/2018)
9.	McCall, Rebecca: 1 article (10/2018)
10.	Vonderau, Jennifer S: 1 article (10/2018)

Related Diseases

1.	Sialorrhea 12/21/2015 - "[Propantheline bromide is effective against dog drooling]." 01/01/2019 - "Improvement in clozapine-induced sialorrhea was seen in meta-analyses of propantheline (studies = 6, risk ratio [RR] 2.38, 95% confidence interval [CI] 1.52-3.73; number needed to treat [NNT] 3, 95% CI 1.9-2.7), diphenhydramine (studies = 5, RR 3.09, 95% CI 2.36-4.03; NNT 2, 95% CI 1.5-2.0), chlorpheniramine (studies = 2, RR 2.37, 95% CI 1.59-3.55; NNT 3, 95% CI 1.6-3.5), and benzamide derivatives (odds ratio [OR] 6.93, 95% CI 3.03-15.86). " 10/11/2023 - "Considering primary nodes' co-primary efficacy outcomes and head-to-head comparisons, efficacy for sialorrhea is most consistent for the following agents, decreasing from metoclopramide through cyproheptadine, sulpiride, propantheline, diphenhydramine, benzhexol, doxepin, amisulpride, chlorpheniramine, to amitriptyline, and atropine (the latter not for nocturnal sialorrhea). "
2.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 10/01/1989 - "We conclude that irritable bowel syndrome is a chronic relapsing disorder and that treatment with a combination of ispaghula husk and propantheline is effective, both in relieving symptoms and in the maintenance of remission." 10/01/1989 - "To examine the long-term management of irritable bowel syndrome we conducted a two-part controlled therapeutic trial on 28 patients who had recovered completely after four to six weeks of treatment with ispaghula husk and propantheline. " 04/01/1987 - "[Multicenter study on the effectiveness and tolerance of a bromazepam + propantheline combination in patients with irritable bowel syndrome]."
3.	Vasovagal Syncope 01/01/1997 - "It was concluded from this study that propantheline bromide is highly effective in preventing neurocardiogenic syncope. " 01/01/1997 - "Clinical efficacy of propantheline bromide in neurocardiogenic syncope: pharmacodynamic implications." 01/01/1997 - "Since cholinergic tone is important in the efferent part of the neurocardiogenic reflex, we investigated the pharmacodynamics and efficacy of propantheline bromide in preventing neurocardiogenic syncope. " 01/01/1997 - "In addition, propantheline bromide's effectiveness is more than would be expected by prevention of cardioinhibition in neurocardiogenic syncope and would support a role for direct cholinergic control of vascular tone."
4.	Abnormal Reflex (Hyperreflexia) 08/01/1980 - "Cystometric response to propantheline in detrusor hyperreflexia: therapeutic implications." 05/01/1986 - "Our results indicate that oxybutynin is more effective than propantheline in the treatment of detrusor hyperreflexia in patients with multiple sclerosis." 05/01/1986 - "Oxybutynin versus propantheline in patients with multiple sclerosis and detrusor hyperreflexia."
5.	Polydipsia 12/21/2015 - "We present a clinical case of severe polydipsia in a six-month-old puppy who had accidentally consumed 50 tablets of propantheline bromide 15 mg. Afterwards the puppy suffered from severe polydipsia, which cleared without treatment after three days. "

Related Drugs and Biologics

1.	Diphenhydramine (Benadryl)
2.	Chlorpheniramine (Chlorphenamine)
3.	oxybutynin (Tavor)
4.	Tablets
5.	ispaghula seed
6.	Atropine
7.	Metoclopramide (Reglan)
8.	Doxepin (Mareen)
9.	Cyproheptadine (Periactin)
10.	Cholinergic Agents (Cholinergics)

Related Therapies and Procedures

1.	Cryotherapy (Therapy, Cold)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Radiotherapy
5.	Intravenous Administration