Promazine (Promazine Hydrochloride)

A phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Also Known As:

Networked: 136 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Foti, Caterina: 2 articles (01/2022 - 09/2017)
2.	Romita, Paolo: 2 articles (01/2022 - 09/2017)
3.	Stingeni, Luca: 2 articles (01/2022 - 09/2017)
4.	Ameline, Alice: 1 article (08/2022)
5.	Kintz, Pascal: 1 article (08/2022)
6.	Raul, Jean-Sébastien: 1 article (08/2022)
7.	Markowicz-Piasecka, Magdalena: 1 article (04/2022)
8.	Podsiedlik, Maria: 1 article (04/2022)
9.	Sikora, Joanna: 1 article (04/2022)
10.	Ambrogio, Francesca: 1 article (01/2022)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/1960 - "The effect of promazine (spraine) on patients with chronic schizophrenia." 01/01/1959 - "Effects of promazine hydrochloride on attention in chronic schizophrenia." 10/01/1957 - "Treatment of chronic schizophrenia with promazine hydrochloride." 10/01/1959 - "Clinical evaluation of promazine therapy for schizophrenia." 02/01/1976 - "The quantitative effectiveness of promazine is of interest with respect to the structural models of the phenothiazines and the dopamine theory of schizophrenia. "
2.	Body Weight (Weight, Body) 12/01/1985 - "Oral promazine proved to be a very effective and safe medication (average dosage in 57 patients without complications: 5.2 mg/kg body weight/90 minutes before CT-scanning; 96% successful sedation procedures) in comparison to 89 patients with i.m. " 12/01/1985 - "promazine (average dosage: 2.3 mg/kg body weight/45 min before CT with 92% adequate sedations but a complication rate of 7.9%). " 06/01/1983 - "Sleep was induced with 2 mg/kg body weight Protactyl syrus (promazie hydrochloride). " 01/01/1982 - "Animals refused to eat bait containing doses of promazine hydrochloride greater than 17 mg/kg body weight." 01/01/1982 - "Promazine hydrochloride at doses of 2 to 17 mg/kg body weight, given orally to wild pronghorn fawns and an adult, did not produce visible signs of tranquilization. "
3.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/01/2022 - "Fifty-two male PTSD outpatients on stable combination treatment with SSRI and benzodiazepines, with persistent sleep disturbances not responding to prescription of zolpidem, flurazepam, nitrazepam, promazine, and levopromazine, were assessed for sleep disturbances improvements after prescription of quetiapine in the evening. " 01/01/2022 - "Quetiapine prescribed in the evening may be successful therapy for persistent sleep disturbances in patients with PTSD and generally good response to an SSRI and benzodiazepine combination, who previously failed to respond to some of the usual hypnotic medication or addition of first-generation antipsychotics: zolpidem, flurazepam, nitrazepam, promazine, and levopromazine."
4.	Fibrosis (Cirrhosis) 01/01/1995 - "A newly developed galactose single point (GSP) method was applied to quantitatively measure the residual liver function in cirrhosis patients and successfully correlated it with promazine elimination half-life (r = 0.770, p < 0.01), total plasma clearance of free drug (r = 0.899, p < 0.005), metabolic clearance of free drug (r = 0.902, p < 0.005), and plasma protein binding (r = 0.822, p < 0.005). "
5.	Mania (Manias) 01/01/2008 - "Efforts to modify phenothiazines to find an antimalarial agent also failed but led to novel antiemetic-sedative antihistamines, including promethazine, promazine, and eventually chlorpromazine--the first effective treatment for schizophrenia and mania. "

Related Drugs and Biologics

1.	Hypnotics and Sedatives (Sedatives)
2.	Chlorpromazine (Thorazine)
3.	Antipsychotic Agents (Antipsychotics)
4.	Benzodiazepines
5.	Quetiapine Fumarate (Seroquel)
6.	Promethazine (Promet)
7.	Phenothiazines
8.	Methotrimeprazine (Levomepromazine)
9.	Nitrazepam (Serenade)
10.	Histamine Antagonists (Antihistamines)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Injections
3.	Anesthesia
4.	Analgesia
5.	Oral Administration