Proline Oxidase (Proline Dehydrogenase)

The first enzyme of the proline degradative pathway. It catalyzes the oxidation of proline to pyrroline-5-carboxylic acid in the presence of oxygen and water. The action is not reversible. The specific activity of proline oxidase increases with age. EC 1.5.3.-.

Also Known As:

Networked: 106 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Phang, James M: 10 articles (01/2019 - 08/2005)
2.	Palka, Jerzy: 9 articles (03/2022 - 01/2015)
3.	Liu, Wei: 6 articles (11/2012 - 08/2010)
4.	Surazynski, Arkadiusz: 5 articles (03/2022 - 08/2005)
5.	Miltyk, Wojciech: 5 articles (02/2022 - 01/2015)
6.	Baszanowska, Weronika: 4 articles (02/2022 - 03/2020)
7.	Oscilowska, Ilona: 4 articles (02/2022 - 12/2021)
8.	Bielawska, Katarzyna: 3 articles (03/2022 - 01/2022)
9.	Huynh, Thi Yen Ly: 3 articles (02/2022 - 03/2020)
10.	Lewoniewska, Sylwia: 3 articles (02/2022 - 03/2020)

Related Diseases

1.	Starvation 02/01/1977 - "Attempts to show that catabolite repression of proline oxidase synthesis could be relieved during NH4+ starvation also failed. " 01/01/2014 - "In particular, nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL. " 01/01/2011 - "Whereas chromatin immunoprecipitation analyses confirm the direct binding of bZIP1 and bZIP53 to promoters of key metabolic genes, such as ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE, the G-box, C-box, or ACT motifs (ACTCAT) have been defined as regulatory cis-elements in the starvation response. "
2.	Schizophrenia (Dementia Praecox) 01/01/2018 - "Previous studies have been conducted to explore the association between proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia (SZ) susceptibility, but providing the controversial results. " 10/02/2015 - "Previous studies have suggested that an association exists between the proline dehydrogenase gene (PRODH) and increased schizophrenia risk. " 03/06/2003 - "A family-based association study of T1945C polymorphism in the proline dehydrogenase gene and schizophrenia in the Chinese population." 01/01/2018 - "Proline dehydrogenase gene (PRODH) polymorphisms and schizophrenia susceptibility: a meta-analysis." 01/01/2017 - "Mutations in the proline dehydrogenase gene PRODH are linked to behavioral alterations in schizophrenia and as part of DiGeorge and velo-cardio-facial syndromes, but the role of PRODH in their etiology remains unclear. "
3.	Neoplasms (Cancer) 12/13/2018 - "We confirmed these findings in vivo, which revealed changed proline dehydrogenase (PRODH) expression in tumor tissues, which in turn influences tumor growth and T cell infiltration. " 01/01/2017 - "Expression of PRODH (proline dehydrogenase), a putative tumor suppressor, was lower in GBM. " 01/01/2014 - "Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis. " 07/15/2012 - "Proline oxidase promotes tumor cell survival in hypoxic tumor microenvironments." 01/01/2012 - "proline dehydrogenase (PRODH), is among a few genes induced rapidly and robustly by P53, the tumor suppressor. "
4.	Breast Neoplasms (Breast Cancer) 12/01/2021 - "Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells." 11/01/2017 - "We discover that proline catabolism via proline dehydrogenase (Prodh) supports growth of breast cancer cells in 3D culture. " 01/01/2014 - "Amongst six cancer cell lines, ZR75-30 human breast cancer cells had the highest basal proline dehydrogenase levels, and mitochondria isolated from ZR75-30 cells consumed oxygen and produced H2O2 with proline as sole substrate. " 03/30/2022 - "NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells." 12/10/2021 - "It has been considered that ER status of breast cancer cells and estrogen availability might determine proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis. "
5.	Mood Disorders (Mood Disorder) 09/01/2005 - "This is the first study on a potential involvement of the proline dehydrogenase locus in bipolar affective disorder. " 09/01/2005 - "In addition, we assessed whether proline dehydrogenase also contributes to bipolar affective disorder, because chromosome 22q11 is also implicated in bipolar affective disorder. " 09/01/2005 - "Neither single marker nor haplotype analysis revealed an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder." 09/01/2005 - "No evidence for an association between variants at the proline dehydrogenase locus and schizophrenia or bipolar affective disorder."

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Related Therapies and Procedures

1.	Therapeutics
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