HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Procollagen-Proline Dioxygenase (Prolyl Hydroxylase)

A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.
Also Known As:
Prolyl Hydroxylase; Peptidyl Prolyl Hydroxylase; Procollagen Prolyl 4-Hydroxylase; Prolyl 4-Hydroxylase; 4-Dioxygenase, Proline,2-Oxoglutarate; 4-Hydroxylase, Procollagen Prolyl; 4-Hydroxylase, Prolyl; Dioxygenase, Procollagen-Proline; Hydroxylase, Peptidyl Prolyl; Hydroxylase, Proline; Hydroxylase, Prolyl; Hydroxylase, Protocollagen Prolyl; Procollagen Proline Dioxygenase; Procollagen Prolyl 4 Hydroxylase; Proline,2 Oxoglutarate 4 Dioxygenase; Prolyl 4 Hydroxylase; Prolyl 4-Hydroxylase, Procollagen; Prolyl Hydroxylase, Peptidyl; Prolyl Hydroxylase, Protocollagen; Proline Hydroxylase; Proline,2-Oxoglutarate 4-Dioxygenase; Protocollagen Prolyl Hydroxylase; Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase
Networked: 624 relevant articles (14 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Schofield, Christopher J: 15 articles (04/2015 - 09/2005)
2. Fong, Guo-Hua: 14 articles (08/2015 - 11/2006)
3. Takeda, Kotaro: 13 articles (01/2015 - 11/2006)
4. Carmeliet, Peter: 11 articles (08/2015 - 05/2008)
5. Ratcliffe, Peter J: 10 articles (03/2015 - 01/2004)
6. Lee, Frank S: 10 articles (05/2014 - 01/2006)
7. Ratan, Rajiv R: 8 articles (07/2012 - 11/2004)
8. Giaccia, Amato J: 7 articles (05/2014 - 02/2007)
9. Maxwell, Patrick H: 7 articles (03/2011 - 01/2004)
10. Kaelin, William G: 6 articles (09/2015 - 10/2002)

Related Diseases

1. Anoxia (Hypoxia)
2. Ischemia
3. Fibrosis (Cirrhosis)
4. Carcinoma (Carcinomatosis)
5. Parkinson Disease (Parkinson's Disease)

Related Drugs and Biologics

1. Oxygen
2. Enzymes
3. Hormones
4. UDP glucose-collagen glucosyltransferase (procollagen glucosyltransferase)
5. Collagen Type III (Type III Collagen)
6. Hydroxyproline (4 Hydroxyproline)
7. oxalylglycine
8. Prostate-Specific Antigen (Semenogelase)
9. Curcumin
10. FOY 305 (camostat)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Transplantation (Transplant Recipients)
3. Heterologous Transplantation (Xenotransplantation)
4. Radiotherapy
5. Drug Therapy (Chemotherapy)