|2.||Pelvic Organ Prolapse
|3.||Sciatica (Sciatic Neuralgia)
|5.||Stress Urinary Incontinence
|1.||Walters, Mark D: 11 articles (05/2015 - 05/2005)|
|2.||Cosson, M: 11 articles (02/2008 - 12/2000)|
|3.||Barber, Matthew D: 10 articles (05/2015 - 05/2005)|
|4.||Sartori, Marair Gracio Ferreira: 10 articles (04/2015 - 11/2003)|
|5.||Maher, Christopher: 10 articles (11/2013 - 02/2006)|
|6.||Altman, Daniel: 10 articles (09/2012 - 01/2004)|
|7.||Girão, Manoel João Batista Castello: 9 articles (04/2015 - 11/2003)|
|8.||Hong, Young Joon: 9 articles (10/2013 - 07/2008)|
|9.||Ahn, Youngkeun: 9 articles (10/2013 - 07/2008)|
|10.||Kang, Jung Chaee: 9 articles (10/2013 - 07/2008)|
11/01/2013 - "In a single RCT, LSC had a superior objective and subjective success rate and lower reoperation rate compared with polypropylene transvaginal mesh for vault prolapse (grade B).Level 3 evidence suggests that vaginal uterosacral ligament suspension, McCall culdoplasty, iliococcygeus fixation and colpocleisis are relatively safe and effective interventions (grade C). "
07/01/2008 - "Several recent studies suggest that transvaginal implantation of polypropylene mesh is an effective and safe technique for the correction of anterior prolapse. "
10/01/2007 - "Transvaginal implantation of polypropylene mesh is an effective and safe technique for the correction of anterior vaginal wall prolapse."
10/01/2007 - "The aim of the present study was to assess the safety and efficacy of anterior vaginal wall repair using polypropylene mesh for the correction of anterior vaginal wall prolapse. "
08/01/2000 - "We determined the efficacy of the use of a tension free prolene mesh to correct a grade III anterior vaginal wall prolapse recurrence. "
12/01/2005 - "These short-term results suggest that hammock using porcine skin collagen implantation by the transobturator route and bilateral sacrospinous fixation is a safe and effective treatment for genital prolapse."
02/01/2004 - "These preliminary results suggest that porcine skin collagen implantation by the transobturator route is a safe and effective treatment for anterior vaginal wall prolapse."
12/01/2005 - "To assess the feasibility and efficacy of the hammock using a porcine skin collagen (Pelvicol) implant for the treatment of genital prolapse by the vaginal route. "
02/01/2004 - "To assess the feasibility and efficacy of porcine skin collagen (Pelvicol) implant by the transobturator route for the treatment of anterior vaginal wall prolapse. "
01/01/2016 - "A 3-year follow-up after anterior colporrhaphy compared with collagen-coated transvaginal mesh for anterior vaginal wall prolapse: a randomised controlled trial."
|3.||Estrogens (Estrogen)FDA Link
11/01/2002 - "Conservative treatment with estrogen is partially effective in reducing the size of the urethral prolapse and may point to hypoestrogenism as one potential cause of this condition in elderly women. "
10/01/2014 - "Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial."
03/01/2013 - "We assessed the feasibility of a factorial randomized trial comparing mesh erosion rates after vaginal mesh prolapse surgery (VM) versus minimally invasive sacral colpopexy (MISC), with or without adjunct vaginal estrogen therapy. "
03/01/2013 - "Computer modeling informs study design: vaginal estrogen to prevent mesh erosion after different routes of prolapse surgery."
07/01/2013 - "Although vaginal estrogen is widely used in women with prolapse, little is known regarding estrogen's benefits on the biomechanical properties of vaginal tissue. "
|4.||Polytetrafluoroethylene (Teflon)FDA Link
10/01/2014 - "Polytetrafluoroethylene neochordae is noninferior to leaflet resection in repair of isolated posterior mitral leaflet prolapse: a multicentre study."
06/01/2001 - "To study the ongoing results of sacrohysteropexy with Teflon mesh for treatment of uterovaginal prolapse in women who desire to preserve their uterus. "
11/01/2013 - "With the use of expanded polytetrafluoroethylene (ePTFE), neochordae leaflet preserving techniques for posterior MV prolapse treatment have emerged. "
04/01/2012 - "Additional MV repair techniques included chordal transfer in 73, a hybrid-flip-over technique in 23, polytetrafluoroethylene neochords in 26, edge-to-edge repair in 11, and commissuroplasty in 9. Prolapse involving more than 1 posterior leaflet scallop was observed in 103 patients (73%), and prolapse of more than 1 anterior leaflet scallop was observed in 76 (54%). "
09/01/2010 - "Cusp prolapse was repaired by commissural re-suspension (n=1), free margin plication (n=10) or re-suspension with polytetrafluoroethylene (PTFE; n=6). "
09/01/2014 - "This is an observational study is designed to assess the influence of age, prolapse and medical co-morbidities on myogenic stem cells growth in-vitro. "
10/01/2011 - "Expert opinion suggests potential benefit of vaginal mesh for recurrences, hysteropexy, and advanced prolapse in patients with medical co-morbidities precluding invasive open and endoscopic sacrocolpopexies; however, comparative clinical trials with long-term data are needed."
03/01/2008 - "In this study we present a clinical series of 45 patients with lumbar disc prolapse who were operated on endoscopically with ENDOSPINE instrumentation (Karl STORZ GmbH and Co. "
06/01/2015 - "Women with prolapse and co-existing SUI are less likely to have SUI after transvaginal prolapse repair with MUS compared with prolapse repair only. "
12/01/2011 - "Management depends upon symptoms and the type and grade of the prolapse as well as any associated medical co-morbidities. "
|6.||Estradiol (Estrace)FDA LinkGeneric
11/01/2009 - "To measure vaginal wall thickness in women with genital prolapse in normal and hypoestrogenic conditions and to correlate sexual dysfunction with vaginal wall thickness and estradiol levels. "
10/01/2000 - "It was concluded that prolapse of the oviduct in sire line turkeys was not associated with any anatomical abnormalities or high plasma estradiol during reproductive development."
12/01/1992 - "Preoperative treatment with oestradiol in women scheduled for vaginal operation for genital prolapse. "
06/01/1992 - "Eleven postmenopausal women used transdermal estradiol (E2) patches for 6 weeks immediately before a vaginal operation for prolapse. "
08/01/1984 - "The role of 17 beta-estradiol in the recovery from oviductal prolapse in layers."
|7.||Raloxifene (Evista)FDA Link
03/01/2012 - "We hypothesize that the abnormal extracellular matrix (ECM) turnover in pelvic tissues of women with prolapse may be attenuated by raloxifene. "
06/01/2007 - "Prolapse was present in two women in the raloxifene group (5%) and six women (11%) in the control group. "
06/01/2007 - "Raloxifene taken long-term does not appear to adversely affect urinary incontinence or prolapse."
01/01/2010 - "A further small trial comparing conjugated equine oestrogen, raloxifene, tamoxifen and placebo in postmenopausal women having pelvic floor muscle training was too small to detect effects on prolapse outcomes. "
09/01/2005 - "Both tamoxifen and raloxifene appear to increase the incidence of pelvic floor prolapse in one trial, although this was not apparent from the licensing studies data for either of the drugs. "
|8.||Anti-Bacterial Agents (Antibiotics)IBA
08/01/2009 - "The objective of this study is to estimate efficacy of prophylactic antibiotics in UTI prevention during CISC for postoperative voiding dysfunction after prolapse/incontinence surgery. "
01/01/2011 - "Protective were prophylactic antibiotics and concomitant prolapse surgery. "
08/01/2009 - "Using decision analysis methods, prophylactic antibiotics are favored for prevention of UTI during CISC to manage voiding dysfunction after prolapse/incontinence surgery."
08/01/2009 - "We constructed a decision tree model to evaluate risks and benefits of prophylactic antibiotics during CISC for voiding dysfunction after prolapse/incontinence surgery. "
08/01/2009 - "Prophylactic antibiotics to prevent urinary tract infection during clean intermittent self-catheterization (CISC) for management of voiding dysfunction after prolapse and incontinence surgery: a decision analysis."
|9.||Proteins (Proteins, Gene)IBA
11/01/2005 - "Positive correlations were found among all proteins in the prolapse group. "
04/01/1993 - "The regeneration of bone with a biodegradable, biocompatible carrier and osteo-regenerative proteins may be possible if the carrier has the appropriate architecture to support osteoconduction and prevent soft-tissue prolapse into ablated bone segments. "
08/01/2003 - "On the basis of these findings, the authors propose that subsequent studies in which permeability of the expanded polytetrafluoroethylene membranes is altered to permit migration of osteoinductive proteins into the defect while blocking prolapse of adjacent soft tissues may help to make guided bone regeneration a realistic alternative for the repair of cranial defects."
02/01/2004 - "The aims of this investigation were to assess the expression messenger RNA and proteins for m-calpain and micro-calpain in the vaginal walls of women with and without uterovaginal prolapse. "
03/01/1999 - "Mg++ is known to be responsible for the function of about 300 enzymes, and its deficiency results in necrosis of the cells due to depletion of energetic stores of phosphates, leads to disturbances in fat metabolism, increased aggregation and shortened survival time of platelets, increased level of factor III, disturbed synthesis of proteins (mitral valve leaflet prolapse) as well as of prostanoid function. "
|10.||Selective Estrogen Receptor Modulators (SERM)IBA
01/01/2010 - "The meta analysis and one other small trial investigated the effect of selective oestrogen receptor modulators (SERMs) for treatment or prevention of osteoporosis but also collected data of the effects on prolapse. "
01/01/2011 - "We believe that the inevitable changes in the estrogen receptor expression over women's different lifetimes may affect the risk of genital prolapse progression, and might contribute to the further search for appropriate selective estrogen receptor modulators as a treatment for women with pelvic organ prolapse."
01/01/2010 - "Only one small trial addressed the primary outcome (prolapse symptoms).One small treatment trial of oestradiol for three weeks before prolapse surgery found a reduced incidence of cystitis in the first four weeks after surgery but this unexpected finding needs to be confirmed in a larger trial.A meta-analysis of adverse effects of a SERM, raloxifene (used for treatment or prevention of osteoporosis in postmenopausal women) found a statistically significant reduction in the need for prolapse surgery at three year follow up (OR 0.50, 95% CI 0.31 to 0.81), but this was statistically significant only in women older than 60 years (OR 0.68, 95% CI 0.22 to 2.08) and the total number of women having prolapse surgery was small. "
12/01/2012 - "When matched for age and parity, women with prior hysterectomy had significantly greater posterior compartment prolapse compared with those without. "
12/01/2012 - "Women with prior hysterectomy had significantly greater prolapse at POP-Q point Bp and worse overall posterior compartment prolapse compared with those without prior hysterectomy. "
08/01/2008 - "This pilot study suggests that our technique is safe and effective and can efficiently repair the pelvic organs prolapse, without undergoing hysterectomy and with a low rate of vaginal erosions."
01/01/2014 - "genital prolapse must be cured by reconstruction of the vaginal support system, not by hysterectomy."
11/01/2013 - "Before meeting the physician, the women completed a questionnaire that asked them to indicate their prolapse treatment preference (uterine preservation vs hysterectomy) for scenarios in which the efficacy of treatment varied. "
06/01/2011 - "Most studies report moderate success rates in the short term following insertion of a pessary for the management of prolapse and concur in the remission of almost all symptoms attributable to the prolapse. "
12/01/2007 - "Pessaries effectively treated urinary symptoms, and most effectively treated prolapse symptoms. "
03/01/2011 - "There was a statistically significant improvement in prolapse, urinary, bowel, and sexual function in both pessary users and those treated surgically. "
05/01/2006 - "After controlling for preoperative prolapse stage and baseline quality of life scores, subjects in the Surgery group had significantly greater improvement in each of the scales of the PFDI and the prolapse and urinary scales of the PFIQ than did the Pessary group (P < .05 for each). "
05/01/2006 - "In the Pessary group, there was a significant improvement in the prolapse and urinary scales of the PFDI, with each demonstrating moderate responsiveness (prolapse: SRM 0.69, ES 0.68; urinary: SRM 0.57, ES: 0.50, P < .001 for each). "
05/01/2000 - "Conventional treatment of haemorrhoids and mucosal prolapse by variations of the ligation-excision technique can achieve good results in expert hands. "
09/01/2007 - "This study was designed to assess the outcome of using a new technique of mucosal ablation using a radiofrequency device followed by its plication for rectal mucosal prolapse and to compare its results with the conventional ligature and excision procedure. "
03/01/2007 - "the endoscopic elastic ligature of mucosal gastric prolapse with multiband after VBG, if confirmed and validated by randomized and prospective trials on a big sample of people, will constitute a valid alternative to surgical treatment of this rare complication."
08/01/2006 - "Randomized controlled study: radiofrequency coagulation and plication versus ligation and excision technique for rectal mucosal prolapse."
06/01/2006 - "The aim of this study is to present a new approach for the treatment of mucosal prolapse of the anterior rectal wall using a multiple longitudinal rubber band ligation procedure. "
08/01/2011 - "This study aims to compare the efficacy of porcine graft-augmented anterior prolapse repair with and without underlying pubocervical fascia plication. "
11/01/2008 - "To assess anatomic and symptomatic efficacy of graft use, we used transvaginal prolapse repair studies that compared graft use with either native tissue repair or repair with a different graft. "
12/01/1999 - "This study demonstrates the feasability and efficacy of using a synthetic graft in the cure via a vaginal approach of genital prolapse. "
11/01/2008 - "To estimate the anatomic and symptomatic efficacy of graft use in transvaginal prolapse repair and to estimate the rates and describe the spectrum of adverse events associated with graft use. "
10/01/2005 - "Natural biologic graft materials (such as fascia lata) have been used to augment prolapse surgery and have a theoretical advantage of causing less erosions; however, a renewed interest in the employment of synthetic mesh in the anterior and posterior segments has increased, partly due to the need to find improved materials with less inconsistent material strength. "
01/01/2013 - "Vaginal hysterectomy is an efficient treatment for uterovaginal prolapse with a swift recovery, short length of hospital stay, and rare serious complications. "
12/01/2005 - "Colpocleisis with colpohysterectomy appears to be an effective treatment for massive uterogenital prolapse in elderly women."
04/01/2014 - "To compare the efficacy of two standard surgical procedures for post-hysterectomy vaginal vault prolapse in patients with levator ani avulsion. "
12/01/2008 - "To assess clinical efficacy of Total Prolift System surgery kit in the treatment of post hysterectomy vaginal vault prolapse. "
01/01/1989 - "This procedure can be carried out with the patient in the lithotomy position when special indications are present: when prolapse has to be cured by the vaginal route and a vaginal suspension has to be carried out; when a vaginal hysterectomy has to be carried out together with a vaginal suspension; when an upper approach vaginal suspension using a Marshall-Marchetti technique has failed. "