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Progeria (Hutchinson Gilford Syndrome)

An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
Also Known As:
Hutchinson Gilford Syndrome; Syndrome, Hutchinson-Gilford; Hutchinson-Gilford Syndrome
Networked: 261 relevant articles (6 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Werner Syndrome (Werner's Syndrome)
2. Premature Aging
3. Down Syndrome (Down's Syndrome)
4. Neoplasms (Cancer)
5. Cockayne Syndrome (Syndrome, Cockayne)

Experts

1. Young, Stephen G: 12 articles (05/2013 - 07/2004)
2. Fong, Loren G: 10 articles (05/2013 - 09/2005)
3. Stewart, Colin L: 8 articles (01/2015 - 06/2003)
4. Lévy, Nicolas: 6 articles (08/2015 - 06/2003)
5. Wehnert, Manfred: 6 articles (01/2015 - 01/2005)
6. Kennedy, Brian K: 6 articles (09/2013 - 01/2005)
7. Osorio, Fernando G: 5 articles (08/2015 - 02/2009)
8. De Sandre-Giovannoli, Annachiara: 5 articles (08/2015 - 06/2003)
9. López-Otín, Carlos: 5 articles (08/2015 - 02/2009)
10. Djabali, Karima: 5 articles (02/2015 - 02/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Progeria:
1. prelamin AIBA
2. Lamin Type A (Lamin A)IBA
3. EnzymesIBA
4. Farnesyltranstransferase (Farnesyltransferase)IBA
5. Adenosine Triphosphate (ATP)IBA
6. p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA
7. Staphylococcal Protein A (A, Protein)IBA
8. Lovastatin (Mevacor)FDA LinkGeneric
9. Reactive Oxygen Species (Oxygen Radicals)IBA
10. Hutchinson Gilford progeria syndromeIBA

Therapies and Procedures

1. Transplants (Transplant)
2. Prostheses and Implants (Prosthesis)
3. Transplantation (Transplant Recipients)
4. Therapeutics
5. Oral Surgery (Maxillofacial Surgery)