Prodigiosin

4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)- 2,2'-bi-1H-pyrrole. A toxic, bright red tripyrrole pigment from Serratia marcescens and others. It has antibacterial, anticoccidial, antimalarial, and antifungal activities, but is used mainly as a biochemical tool.

Also Known As:

2,2'-Bi-1H-pyrrole, 4-methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)-

Networked: 149 relevant articles (5 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Obayemi, J D: 9 articles (09/2020 - 09/2014)
2.	Soboyejo, W O: 9 articles (09/2020 - 09/2014)
3.	Pérez-Tomás, Ricardo: 9 articles (01/2013 - 02/2003)
4.	Danyuo, Y: 7 articles (01/2019 - 09/2014)
5.	Odusanya, O S: 7 articles (01/2019 - 09/2014)
6.	Soto-Cerrato, Vanessa: 7 articles (01/2013 - 12/2003)
7.	Dozie-Nwachukwu, S: 6 articles (09/2020 - 09/2014)
8.	Malatesta, K: 6 articles (08/2017 - 09/2014)
9.	Montaner, Beatriz: 6 articles (02/2007 - 02/2003)
10.	Chang, Chia-Che: 5 articles (12/2012 - 03/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Prodigiosin, a secondary metabolite red pigment produced by Serratia marcescens, has an interesting apoptotic efficacy against cancer cell lines with low or no toxicity on normal cells. " 06/01/2020 - "Therefore, further studies will be needed to elucidate the antitumor mechanisms of prodigiosin action against tumor strains from flow cytometry tests. " 10/01/2016 - "Several studies have shown that prodigiosin isolated from cell wall of Serratia marcescens induces apoptosis in different kinds of cancer cells. " 01/01/2016 - "In this study, we investigated the effects of the small-molecule prodigiosin, which restores the p53 pathway in tumor cells via p73 activation, on CRCSCs in vitro and in vivo Prodigiosin prevented colonosphere formation independent of p53 status and reduced the viability of self-renewing, 5-fluorouracil-resistant Aldefluor positive [Aldefluor(+)] CRCSCs in vitro Furthermore, prodigiosin inhibited the growth of xenograft tumors initiated with Aldefluor+ cells without toxic effects and limited the tumorigenic potential of these cells. " 10/31/2023 - "Cell viability analysis revealed prodigiosin to be modestly cytotoxic against HEK293, a non-cancer human cell line. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 08/01/2022 - "The findings of in vitro experimental studies suggest that using the prodigiosin pigment as a drug candidate for cancer and neurodegenerative disease therapy is both effective and safe."
3.	Neuroblastoma 10/31/2007 - "Prodigiosin is more potent, with IC50 values lower than 1.5 microM in N-type neuroblastoma cells and around 7 microM in the S-type neuroblastoma cell line. " 10/31/2007 - "In this study we report the effect and mechanisms of action of prodigiosin against different human neuroblastoma cell lines: SH-SY5Y, LAN-1, IMR-32 (N-type) and SK-N-AS (S-type). " 10/31/2007 - "Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines." 10/31/2007 - "This mechanism of action differs from those induced by conventional chemotherapeutic drugs, suggesting a possible role for prodigiosin to enhance the effect of antitumor agents in the treatment of neuroblastoma."
4.	Alzheimer Disease (Alzheimer's Disease) 02/01/2023 - "Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride-induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO-1/NF-κB signaling."
5.	Colonic Neoplasms (Colon Cancer) 02/15/2014 - "In this study, we report the identification of prodigiosin that can reactivate p53 family-dependent transcriptional activity in p53-deficient human colon cancer cells. " 06/01/2023 - "This research investigates the potentials of prodigiosin(PG) derived from bacteria and its formulations against triple-negative breast (TNB), lung, and colon cancer cells. " 03/16/2001 - "These results indicate that prodigiosin induces apoptosis in colon cancer cells." 03/16/2001 - "Here we characterize the apoptotic action of prodigiosin in colon cancer cells. " 03/16/2001 - "Prodigiosin-induced apoptosis in human colon cancer cells."

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Caspase 9
3.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
4.	Chlorides
5.	Aluminum
6.	obatoclax
7.	Antineoplastic Agents (Antineoplastics)
8.	Proteins (Proteins, Gene)
9.	Paclitaxel (Taxol)
10.	Nucleotides

Related Therapies and Procedures

1.	Therapeutics
2.	Bioreactors (Bioreactor)
3.	Respiratory Therapy (Therapy, Respiratory)
4.	Injections
5.	Complementary Therapies (Alternative Medicine)