|2.||Proctocolitis (Hemorrhagic Proctocolitis)
|1.||Hille, Andrea: 7 articles (09/2009 - 09/2005)|
|2.||Christiansen, Hans: 7 articles (09/2009 - 09/2005)|
|3.||Hess, Clemens F: 6 articles (09/2009 - 09/2005)|
|4.||Hermann, Robert M: 6 articles (09/2009 - 12/2005)|
|5.||Schmidberger, Heinz: 5 articles (09/2009 - 09/2005)|
|6.||Sabourin, Jean-Christophe: 4 articles (09/2015 - 06/2009)|
|7.||Benderitter, Marc: 4 articles (09/2015 - 06/2009)|
|8.||Herrmann, Markus K A: 4 articles (09/2009 - 01/2008)|
|9.||Pradier, Olivier: 4 articles (09/2009 - 09/2005)|
|10.||Takeshima, F: 4 articles (12/2005 - 01/2000)|
|1.||Mesalamine (Mesalazine)FDA LinkGeneric
05/01/2012 - "However, because most studies included only patients with left-sided disease or proctitis, the efficacy of topical mesalamine in preventing relapse in patients with more extensive quiescent UC is not known."
11/01/2010 - "In active ulcerative proctitis the once-daily administration of a 1 g mesalamine suppository is as effective and safe, yet considerably more convenient, than the standard thrice-daily administration of a 0.5 g mesalamine suppository."
01/01/1992 - "Therapeutic efficacy of mesalazine controlled-release suppository 1 g once daily was compared with that of a placebo during 2 weeks in 50 patients (26 in the mesalazine group, 24 in the placebo group) with ulcerative proctitis, in a double-blind randomized trial. "
02/01/1998 - "Daily administration of rectal formulations of mesalazine is effective in preventing relapse of ulcerative proctitis. "
01/01/1992 - "It is concluded that a once-a-day administration of 1 g mesalazine controlled-release suppository is effective for topical treatment of patients with ulcerative proctitis."
|2.||Formaldehyde (Formol)FDA Link
04/01/2007 - "APC is probably less effective in very severe cases of hemorrhagic radiation proctitis; in these cases topical formalin or a combination of APC and topical formalin can be useful. "
06/01/2005 - "Although formalin instillation has been proven to be an effective treatment of hemorrhagic radiation proctitis, different techniques with varying success rates have been reported. "
01/01/2003 - "Local application of 4% formaldehyde for the treatment of haemorrhagic radiation-induced proctitis gives good results, is well tolerated and easy to perform. "
02/01/2013 - "According to a revision of the literature and our experience, despite the small number of patients in our trial, we can state that the application of 4 % formalin solution is an effective, safe, and well-tolerated treatment for chronic radiation-induced hemorrhagic proctitis with minimal discomfort and no severe complications."
10/01/2010 - "Local instillation of 4% formalin is an effective treatment for uncontrolled radiation induced haemorrhagic proctitis."
|3.||Suppositories (Vaginal Suppositories)IBA
10/01/2006 - "Rectally administered 5-ASA and corticosteroid suppositories are effective treatment for most ulcerative proctitis patients. "
12/01/1987 - "5-ASA suppositories are safe, well-tolerated, and effective treatment for active distal proctitis."
09/01/1962 - "A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis."
01/01/2015 - "Proctitis could be a complication of stapled hemorrhoidopexy with a good response to conservative treatment with suppositories."
10/01/2006 - "Suppositories should be considered the treatment of choice for proctitis and distal sigmoiditis. "
|4.||Budesonide (Pulmicort)FDA LinkGeneric
11/01/2015 - "Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis."
04/01/2015 - "Budesonide rectal foam was well tolerated and more efficacious than placebo in inducing remission in patients with mild to moderate ulcerative proctitis and ulcerative proctosigmoiditis. "
01/15/2006 - "Rectal budesonide is an effective treatment of active ulcerative proctitis or proctosigmoiditis. "
04/01/2015 - "We performed 2 randomized, phase 3 trials to evaluate the ability of budesonide rectal foam, formulated to optimize retention and provide uniform delivery of budesonide to the rectum and distal colon, to induce remission in patients with ulcerative proctitis or ulcerative proctosigmoiditis. "
04/01/2015 - "Budesonide foam induces remission in patients with mild to moderate ulcerative proctitis and ulcerative proctosigmoiditis."
|5.||Sucralfate (Carafate)FDA LinkGeneric
09/01/2005 - "Sucralfate does not ameliorate acute radiation proctitis: randomised study and meta-analysis."
10/01/2002 - "Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis: longer term follow-up of a phase III trial--Trans-Tasman Radiation Oncology Group."
11/01/1997 - "A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis."
09/01/1998 - "Oral sucralfate may provide a novel approach to the treatment of intractable postradiation proctitis."
11/01/1997 - "For the placebo and sucralfate arms 95 and 88% (difference 7 +/- 11%) suffered some degree of proctitis, with 71 and 61% (difference 10 +/- 19%) reaching grade 2, respectively. "
02/01/1990 - "This is a report of a phase I/II study of 13 patients treated with sodium pentosanpolysulfate (PPS) for chronic radiation-induced proctitis. "
02/01/1990 - "Preliminary results of a phase I/II study of sodium pentosanpolysulfate in the treatment of chronic radiation-induced proctitis."
04/20/1985 - "[Clinical studies on the effect of sodium arginate on radiation esophagitis and proctitis]."
07/01/1986 - "Electrolyte composition of the rectal fluid, which contained 134 mmol potassium and 22 mmol sodium per liter was remarkable and similar to that of normal stool water and anal discharges of patients with ulcerative proctitis."
12/01/2013 - "Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate."
10/07/2000 - "Topical butyrate for acute radiation proctitis: randomised, crossover trial."
12/01/2008 - "No correlation was seen between the efficacy of butyrate enemas on acute proctitis and prevention or development of late toxicity, respectively. "
12/01/2013 - "Early treatment and prevention of the radiation proctitis--composite enemas containing sodium butyrate."
12/01/2008 - "A statistical significant difference between the incidence and the severity of proctitis before start of treatment with sodium butyrate enemas compared to 14 days later and compared to the end of irradiation treatment course, respectively, was found. "
12/01/2008 - "31 patients had been treated with sodium butyrate enemas for radiation-induced acute grade II proctitis which had developed after 40 Gy in median. "
|8.||Adrenal Cortex Hormones (Corticosteroids)IBA
08/01/2014 - "Topically administered 5-aminosalicylates (5-ASA) and corticosteroids are effective in the treatment of proctitis, although they seem to be underused in everyday practice. "
01/01/2014 - "Topical therapy with 5-ASA or corticosteroids was given in 26% of patients with proctitis, a combined systemic and topical treatment was given in 13%, whereas systemic treatment with 5-ASA without topical treatment was given in 29%. "
03/01/1992 - "Idiopathic proctitis is usually due to either ulcerative colitis or Crohn's disease, and in both conditions corticosteroids, either systemic or topical, provide the mainstay of treatment. "
12/01/2015 - "In neoadjuvant radiochemotherapy for locally advanced rectal cancer (LARC), the toxicity that is most frequently observed is proctitis, usually treated with topical corticosteroids or mesalazine. "
02/01/2008 - "Although 5-aminosalicylic acid (5-ASA, mesalazine) and corticosteroids remain the important drugs used in the management of distal colitis and proctitis, recent expansion of delivery options of 5-ASA and high level evidence regarding efficacy have led to a shift in treatment strategies. "
|9.||Tacrolimus (Prograf)FDA LinkGeneric
09/01/2010 - "Local tacrolimus treatment is effective in a subgroup of proctitis patients. "
11/15/2008 - "This prospective pilot study demonstrated that topical rectal tacrolimus ointment can be effective in ulcerative proctitis. "
11/15/2008 - "Topically administered tacrolimus, however, may also be effective in proctitis. "
08/01/2014 - "Although only very little data has been published, rectal tacrolimus seems to be safe and of efficacy in ulcerative proctitis resistant to standard therapy."
02/01/2009 - "Thirteen of 19 patients (3/5 left-sided UC, 0/2 left-sided CD, and 10/12 proctitis) showed clinical improvement of disease activity after 4 weeks of local tacrolimus treatment. "
06/01/2008 - "Rebamipide enema therapy for radiation proctitis is a safe and effective treatment of radiation proctitis. "
06/01/2008 - "We assessed the efficacy of rebamipide enema to control symptoms and proctoscopic findings from radiation proctitis. "
06/01/2008 - "We suggest the value of rebamipide enema in the treatment of radiation proctitis when other conservative management or first treatment has failed."
12/01/2005 - "Efficacy of rebamipide enemas in active distal ulcerative colitis and proctitis: a prospective study report."
07/01/2000 - "Anti-inflammatory effect of rebamipide enema on proctitis type ulcerative colitis: a novel therapeutic alternative."
04/01/1994 - "Corticosteroid enemas represent effective treatment for ulcerative proctitis, but absorption into the systemic circulation may have undesirable metabolic consequences. "
05/01/1989 - "5-ASA enemas do not appear to be effective in the treatment of radiation proctitis."
06/01/1999 - "A prospective, randomized, double-blind trial comparing short chain fatty acid enemas with placebo was conducted in 19 patients with chronic radiation proctitis. "
06/01/1999 - "The aim of the present study was to evaluate the therapeutic effect of short chain fatty acid enemas in patients with chronic radiation proctitis. "
06/01/2008 - "Rebampide enema therapy as a treatment for patients with chronic radiation proctitis: initial treatment or when other methods of conservative management have failed."
|2.||Argon Plasma Coagulation
12/01/2001 - "Argon plasma coagulation is an effective treatment for refractory hemorrhagic radiation proctitis."
12/01/2005 - "Future prospective controlled trials are necessary to confirm the efficacy of argon plasma coagulation in the treatment of radiation proctitis."
05/01/2012 - "Argon plasma coagulation (APC) has been well described for its efficacy in treating radiation proctitis. "
03/01/2011 - "Large-volume argon plasma coagulation in the management of chronic radiation proctitis."
07/01/2010 - "Efficacy and safety of single-session argon plasma coagulation in the management of chronic radiation proctitis."
11/01/2000 - "Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy."
09/01/2013 - "Development of grade 3 proctitis occurred as a late radiotherapy (RT)-related toxicity in only one patient (10%) treated with CCR. "
09/01/2012 - "Radiation proctitis is a complex disease requiring support ranging from initial contact with the patient until several years after completion of radiotherapy. "
08/01/2011 - "Acute radiation proctitis (ARP) is a common side effect of pelvic radiotherapy, and its management is challenging in daily practice. "
05/01/2011 - "A pilot study was undertaken of 12 patients with haemorrhagic radiation proctitis after radiotherapy. "
09/01/2008 - "Hyperbaric oxygen therapy significantly improved the healing responses in patients with refractory radiation proctitis, generating an absolute risk reduction of 32% (number needed to treat of 3) between the groups after the initial allocation. "
12/01/2006 - "To evaluate the efficacy of hyperbaric oxygen therapy in treatment of severe refractory radiation-induced hemorrhagic proctitis. "
12/01/2006 - "Treatment of refractory radiation-induced hemorrhagic proctitis with hyperbaric oxygen therapy."
09/01/1998 - "Our objective was to investigate the effectiveness of hyperbaric oxygenation (HBO) in the treatment of radiation proctitis. "
09/01/1997 - "The results of hyperbaric oxygen therapy (HBO2) used in the treatment of chronic radiation proctitis are reported. "
01/01/2005 - "From single studies there was a significantly improved chance of healing following HBOT for radiation proctitis (relative risk (RR) 2.7, 95% confidence Interval (CI) 1.2 to 6.0, P = 0.02, numbers needed to treat (NNT) = 3), and following both surgical flaps (RR 8.7, 95% CI 2.7 to 27.5, P = 0.0002, NNT = 4) and hemimandibulectomy (RR 1.4, 95% CI 1.1 to 1.8, P = 0.001, NNT = 5). "
01/01/2012 - "From single studies there was a significantly increased chance of improvement or cure following HBOT for radiation proctitis (RR 1.72; 95% CI 1.0 to 2.9, P = 0.04, NNTB 5), and following both surgical flaps (RR 8.7; 95% CI 2.7 to 27.5, P = 0.0002, NNTB = 4) and hemimandibulectomy (RR 1.4; 95% CI 1.1 to 1.8, P = 0.001, NNTB 5). "