Prochlorperazine (Compazine)

A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)

Also Known As:

Compazine; Prochlorperazine Edisylate; Prochlorperazine Edisylate Salt; Prochlorperazine Maleate; Edisylate Salt, Prochlorperazine; Edisylate, Prochlorperazine; Maleate, Prochlorperazine; Salt, Prochlorperazine Edisylate; 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-

Networked: 423 relevant articles (74 outcomes, 84 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Friedman, Benjamin W: 5 articles (01/2021 - 10/2008)
2.	Vinson, David R: 5 articles (11/2017 - 03/2002)
3.	Otręba, Michał: 4 articles (06/2022 - 09/2018)
4.	Kelley, Nancy E: 4 articles (06/2016 - 01/2012)
5.	Grazioli, Irene: 4 articles (12/2009 - 09/2002)
6.	Uslenghi, Carla: 4 articles (12/2009 - 09/2002)
7.	Onishi, Hideki: 3 articles (01/2020 - 12/2007)
8.	Naito, Takafumi: 3 articles (01/2019 - 02/2014)
9.	Bailey, Benoit: 3 articles (03/2012 - 05/2008)
10.	Tepper, Deborah E: 3 articles (03/2012 - 01/2012)

Related Diseases

1.	Vomiting 01/01/1987 - "Although prochlorperazine was less effective in offering complete protection against emesis, only 15% of the patients receiving this drug vomited more than five times. " 12/01/1990 - "The median duration per episode of vomiting was also significantly greater in the prochlorperazine group than in the other two groups. " 04/01/1984 - "In this study, 40 patients whose active vomiting stemmed from various causes were given 2.5 mg of prochlorperazine by slow intravenous push. " 01/01/1998 - "The frequency of vomiting was also reduced by buccal prochlorperazine compared with oral prochlorperazine, but this difference was only of borderline significance (p = 0.07). " 08/01/1987 - "Prochlorperazine and vomiting after eye surgery."
2.	Migraine Disorders (Migraine) 07/01/2019 - "To compare the efficacy of buccally absorbed prochlorperazine (BAP) to intravenous prochlorperazine (IVP) for the abortive treatment of migraine headaches. " 08/01/1994 - "To assess the safety and efficacy of rectal prochlorperazine in the treatment of acute migraines. " 08/01/1994 - "Safety and efficacy of rectal prochlorperazine for the treatment of migraine in the emergency department." 10/01/2002 - "To study the efficacy and tolerability of prochlorperazine (PCZ) management of acute migraine. " 04/01/2001 - "To study the effectiveness of prochlorperazine in aborting severe, intractable migraines in children. "
3.	Nausea 12/01/1990 - "The median duration and severity per episode of nausea was significantly greater in the group receiving prochlorperazine alone versus the other two groups. " 11/01/2011 - "At this facility, the patient developed nausea and was given 2 doses (unknown amount and route) of prochlorperazine. " 07/01/2011 - "Eighty-eight percent (n = 24) reported the use of prochlorperazine; they experienced a 75% median nausea reduction after 4 hours, with minimal side effects. " 02/01/2011 - "Nausea scores at baseline and 0-30 minutes were severe and similar between groups; however, at 31-60 and 61-120 minutes, patients receiving prochlorperazine had better control of nausea (24.9 vs. 43.7 mm, p=0.03; 16.8 vs. 34.3 mm, p=0.05). " 11/01/2010 - "There was no significant difference in the incidence of nausea on commencement of all groups combined with prochlorperazine at dosage of 15 mg/d. "
4.	Headache (Headaches) 04/01/2000 - "The objective of this study was to determine the efficacy of MgSO(4) vs. prochlorperazine in emergency department (ED) patients with acute headache. " 02/24/1989 - "Randomized double-blind trial of intravenous prochlorperazine for the treatment of acute headache." 01/01/2018 - "A Comparison of Headache Treatment in the Emergency Department: Prochlorperazine Versus Ketamine." 10/01/2000 - "After intravenous prochlorperazine treatment, 121 (90%) achieved a 50% or greater reduction of headache intensity, including 85 (63%) who became headache-free. " 03/01/1992 - "High prochlorperazine doses (10 mg.) aborted the most headaches (95%) in the shortest time, but caused more sedation and akathesia. "
5.	Postoperative Nausea and Vomiting (PONV) 11/01/1993 - "This study demonstrates that prochlorperazine at the dose used is effective in preventing postoperative nausea in the patient population studied." 10/01/1996 - "prochlorperazine reduced the severity of postoperative vomiting. " 09/01/1989 - "The effectiveness of 10 mg IV prochlorperazine in preventing postoperative nausea and vomiting was compared with placebo when given perioperatively to 100 patients in a prospective double-blind randomized trial. " 09/01/1996 - "The frequency of those experiencing no PONV was increased from 27% (placebo) by prochlorperazine i.m. " 04/01/1990 - "The incidence of postoperative emesis was 11/25 (44%) in group 1, 3/25 (12%, p less than 0.05) in group 2, 9/25 (36%) in group 3, and 3/25 (12%, p less than 0.05) in group 4. Our results suggest that electro-acupuncture is as effective as prochlorperazine, and may be better than transcutaneous electrical nerve stimulation, in reducing postoperative emesis."

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