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Pro-Opiomelanocortin (Proopiomelanocortin)

A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
Also Known As:
Proopiomelanocortin; POMC; ACTH-Endorphin Precursor; ACTH-beta-Lipotropin Precursor; Corticotropin-beta-Lipotropin Precursor; Endorphin-ACTH Precursor; Opiocortin; Pre-POMC; Pre-pro-opiocortin; Preproopiomelanocortin; Pro-ACTH-Endorphin; Pro-Opio-Melanocortin; Proopiocortin; ACTH Endorphin Precursor; ACTH beta Lipotropin Precursor; Corticotropin beta Lipotropin Precursor; Endorphin ACTH Precursor; Pre POMC; Pre pro opiocortin; Pro ACTH Endorphin; Pro Opio Melanocortin; Pro Opiocortin; Pro Opiomelanocortin; Pro-Opiocortin; Opiomelanocortin, pro-
Networked: 1235 relevant articles (28 outcomes, 154 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Low, Malcolm J: 17 articles (04/2015 - 06/2003)
2. Elmquist, Joel K: 15 articles (06/2015 - 08/2002)
3. Cowley, Michael A: 14 articles (01/2015 - 06/2003)
4. Lowell, Bradford B: 13 articles (06/2015 - 06/2004)
5. O'Rahilly, Stephen: 12 articles (05/2011 - 08/2002)
6. White, Anne: 10 articles (09/2015 - 08/2002)
7. Nillni, Eduardo A: 9 articles (04/2015 - 04/2004)
8. Horvath, Tamas L: 9 articles (09/2014 - 03/2004)
9. Tai, Ming-Hong: 9 articles (06/2014 - 02/2006)
10. Coppari, Roberto: 9 articles (03/2012 - 06/2004)

Related Diseases

1. Obesity
2. AIDS-Related Complex (ARC)
3. Body Weight (Weight, Body)
4. Neoplasms (Cancer)
5. Pain (Aches)

Related Drugs and Biologics

1. Pro-Opiomelanocortin (Proopiomelanocortin)
2. Messenger RNA (mRNA)
3. Leptin
4. Insulin (Novolin)
5. Hormones
6. Glucose (Dextrose)
7. Peptides
8. beta-Endorphin (Endorphin, beta)
9. Neuropeptide Y
10. Leptin Receptors

Related Therapies and Procedures

1. Thymectomy
2. Tourniquets
3. Intranasal Administration
4. Analgesia
5. Surgical Instruments (Clip)