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Prions

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
Also Known As:
Encephalopathy Virus, Mink; Mink Encephalopathy Virus; PrP Proteins; Prion Proteins
Networked: 1349 relevant articles (16 outcomes, 83 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Prusiner, Stanley B: 49 articles (10/2015 - 03/2002)
2. Collinge, John: 43 articles (09/2015 - 10/2002)
3. Aguzzi, Adriano: 26 articles (12/2015 - 01/2002)
4. Soto, Claudio: 25 articles (05/2015 - 08/2002)
5. DeArmond, Stephen J: 24 articles (10/2015 - 03/2002)
6. Giles, Kurt: 24 articles (10/2015 - 01/2006)
7. Brandner, Sebastian: 24 articles (09/2015 - 05/2004)
8. Wadsworth, Jonathan D F: 21 articles (09/2015 - 12/2002)
9. Laude, Hubert: 21 articles (08/2015 - 01/2004)
10. Yokoyama, Takashi: 21 articles (01/2015 - 02/2002)

Related Diseases

1. Infection
2. Prion Diseases (Transmissible Spongiform Encephalopathies)
3. Scrapie
4. Neurodegenerative Diseases (Neurodegenerative Disease)
5. Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)

Related Drugs and Biologics

1. Amyloid (Amyloid Fibrils)
2. Protein Isoforms (Isoforms)
3. Synucleins
4. Doxycycline (Vibramycin)
5. Ligands
6. Suramin (Suramin Sodium)
7. Ethanol (Ethyl Alcohol)
8. Pattern Recognition Receptors
9. Molecular Chaperones (Chaperone, Molecular)
10. phenothiazine

Related Therapies and Procedures

1. Homologous Transplantation (Allograft)
2. Transplants (Transplant)
3. Immunotherapy
4. Quantum Dots (Quantum Dot)
5. Laryngoscopes