|1.||Prusiner, Stanley B: 49 articles (10/2015 - 03/2002)|
|2.||Collinge, John: 43 articles (09/2015 - 10/2002)|
|3.||Aguzzi, Adriano: 26 articles (12/2015 - 01/2002)|
|4.||Soto, Claudio: 25 articles (05/2015 - 08/2002)|
|5.||DeArmond, Stephen J: 24 articles (10/2015 - 03/2002)|
|6.||Giles, Kurt: 24 articles (10/2015 - 01/2006)|
|7.||Brandner, Sebastian: 24 articles (09/2015 - 05/2004)|
|8.||Wadsworth, Jonathan D F: 21 articles (09/2015 - 12/2002)|
|9.||Laude, Hubert: 21 articles (08/2015 - 01/2004)|
|10.||Yokoyama, Takashi: 21 articles (01/2015 - 02/2002)|
01/01/2004 - "Besides improved tolerance and theoretically lower chances of infection by prions, the latter may be more effective in terms of clinical pregnancy rates, FSH requirement and cost effectiveness. "
09/01/2015 - "Here, we report on an improved bioassay using selective precipitation of tau prions from human PSP brain homogenates before infection of the HEK cells. "
07/01/2013 - "Our results suggest that this common, migratory North American scavenger is capable of translocating infectious prions to disease-free areas, potentially seeding CWD infection where no other initial source of pathogen establishment is forthcoming. "
01/01/2015 - "The purpose of this study was to identify and characterize a cell line that was susceptible to ruminant-derived prions and to establish a stable prion infection within it. "
08/01/2014 - "This study demonstrates anterograde spread of prions within nerve fibers prior to infection of peripheral synapses (i.e., neuromuscular junction) and infection of peripheral tissues (i.e., muscle cells). "
|2.||Prion Diseases (Transmissible Spongiform Encephalopathies)
01/01/2015 - "We hypothesize that the presence of heterologous prion proteins from one species might therefore constitute an effective treatment for prion disease in another species. "
06/01/2015 - "A few studies showed that amplification methods can detect prions in either cerebrospinal fluid, olfactory epithelium, blood and/or urine in various human prion diseases. "
04/01/2015 - "In contrast to recent progress in studies of laboratory rodent-adapted prions, current understanding of the molecular basis of human prion diseases and, especially, their vast phenotypic diversity is very limited. "
01/01/2015 - "Previous studies established that prion disease with unique strain-specific phenotypes could be induced by in vitro-formed recombinant PrP (rPrP) fibrils with structures different from that of authentic prions, or PrP(Sc). "
07/01/2013 - "A study demonstrating an interaction between cytosolically-exposed prion protein and MGRN1 suggested that disruption of MGRN1 function may contribute to prion disease pathogenesis, but we recently showed that neither loss of MGRN1 nor MGRN1 overexpression influences the onset or progression of prion disease following intracerebral inoculation with Rocky Mountain Laboratory prions. "
01/01/2006 - "Improved bioassays allowed the transforming principle (TP) to be purified from pneumococci and prions from scrapie-infected hamster brains. "
08/01/2012 - "The diversity of strains of ovine prions within classical scrapie isolates was investigated by transmission studies in wild type mice. "
01/01/2011 - "Unlike other studies, this study utilized a scrapie cell assay to determine infectivity and quantity of infectious prions. "
12/01/2010 - "In the present study, to elucidate the enteric invasion mechanism of prions and to investigate the age-dependent transmission mechanism suggested by epidemiological studies, wild-type and SCID mice were orally administered brain homogenate from scrapie (Tsukuba 1)-infected mice during the suckling and weaning stages, before being analyzed histopathologically. "
03/01/2009 - "This study concludes that all native sheep breeds are poor in scrapie-resistant PrP genotypes and could contract scrapie if exposed to prions."
|4.||Neurodegenerative Diseases (Neurodegenerative Disease)
11/01/1996 - "Yeast prions, as the genetic elements are called, can be cured, offering new insights into the molecular processes involved in protein-based inheritance and new hope for the treatment of neurodegenerative diseases in man."
07/15/2014 - "An increasing number of studies argues that self-propagating protein conformations (i.e., prions) feature in the pathogenesis of several common neurodegenerative diseases. "
03/15/2008 - "In this study, a dynamic resonance-based technique was used to detect prion proteins (PrP), which in conformationally altered forms are known to cause neurodegenerative diseases in animals as well as humans. "
11/02/2015 - "Prions cause neurodegenerative diseases for which no cure exists. "
11/01/2015 - "Prions are unprecedented infectious pathogens that are devoid of nucleic acid and cause a group of rare and invariably fatal neurodegenerative disorders, affecting approximately 1 person per 1 million inhabitants annually worldwide. "
|5.||Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)
04/01/2013 - "In addition, we report on the adaptation of quantitative PMCA to human variant Creutzfeldt-Jakob disease (vCJD) prions on steel wires for prion disinfection studies. "
10/01/2008 - "To understand the pathophysiology specific to variant Creutzfeldt-Jakob Disease (vCJD), in vitro electrophysiological studies were performed in a mouse model in which human-derived vCJD prions were transmitted to transgenic mice expressing human instead of murine prion protein. "
09/01/2007 - "The study of brain histological specimens from patients with Creutzfeldt-Jakob disease (CJD) revealed the active reproduction and accumulation of pathological prions in the epitheliocytes of cerebral vascular brain plexuses in a new variant of CJD. "
10/01/2015 - "Disappointingly, none of the four new 2-AMTs prolonged the lives of mice expressing a chimeric human/mouse PrP transgene inoculated with Creutzfeldt-Jakob disease prions. "
04/01/2015 - "Compared with transgenic mice expressing unaltered human PrP, mice expressing the human-elk chimeric PrP were highly susceptible to elk and deer CWD prions but were concurrently less susceptible to human Creutzfeldt-Jakob disease prions. "
|1.||Amyloid (Amyloid Fibrils)
|2.||Protein Isoforms (Isoforms)
|6.||Suramin (Suramin Sodium)
|7.||Ethanol (Ethyl Alcohol)
|8.||Pattern Recognition Receptors
|9.||Molecular Chaperones (Chaperone, Molecular)
|1.||Homologous Transplantation (Allograft)
|4.||Quantum Dots (Quantum Dot)