Presbycusis

Gradual bilateral hearing loss associated with aging that is due to progressive degeneration of cochlear structures and central auditory pathways. Hearing loss usually begins with the high frequencies then progresses to sounds of middle and low frequencies.

Also Known As:

Presbycuses

Networked: 230 relevant articles (13 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hearing Loss (Hearing Impairment)
2.	Sensorineural Hearing Loss
3.	Tinnitus
4.	Ototoxicity
5.	Seizures (Absence Seizure)

Experts

1.	Sun, Yu: 9 articles (12/2021 - 07/2010)
2.	Kong, Wei-Jia: 6 articles (12/2021 - 07/2010)
3.	Frisina, Robert D: 6 articles (06/2021 - 11/2005)
4.	Zhu, Xiaoxia: 5 articles (06/2021 - 01/2007)
5.	Yuan, Jie: 5 articles (03/2020 - 07/2015)
6.	Zhao, Xue-Yan: 4 articles (12/2021 - 02/2013)
7.	Kong, Wen: 4 articles (03/2020 - 07/2015)
8.	Zhong, Yi: 4 articles (07/2015 - 07/2010)
9.	Syka, Josef: 4 articles (08/2013 - 01/2007)
10.	Iwai, Hiroshi: 4 articles (09/2012 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Presbycusis:

1.	gamma-Aminobutyric Acid (GABA)IBA 02/01/2015 - "However, to date there has been a paucity of studies exploring changes to the GABA concentrations in the auditory region of patients with presbycusis. " 10/01/2012 - "In comparison to the aged group and the youth group, the changes of NAA, GABA, Cho and Glu is found in auditory cortex in patients with presbycusis." 10/01/2012 - "GABA/Cr ratio and Glu/Cr ratio were significant difference between presbycusis group and youth group (P < 0.05). " 01/01/1998 - "The reduction of GABA positive neurons in the aged rat cochlear nucleus may be related to presbycusis." 07/01/1990 - "Immunocytochemical and neurochemical evidence for age-related loss of GABA in the inferior colliculus: implications for neural presbycusis."
2.	MineralocorticoidsIBA 02/01/2021 - "Future studies that further evaluate the safety and efficacy of mineralocorticoids for presbycusis are still required for this potentially paradigm shifting therapy to gain widespread acceptance." 02/01/2021 - "Although research on mineralocorticoids to prevent and retard presbycusis in humans shows promise and the potential to radically change the way clinicians approach age-related hearing loss, it remains in its infancy. "
3.	3' Untranslated Regions (3' UTR)IBA 03/01/2018 - "The 'TT' genotype of MTHFR C677T and '152 bp/152 bp' genotype of TS1494indel6 bp showed statistically significant risk for presbycusis while CC genotype of MTHFR A1298C, '2R/2R' genotype of TSER at 3'UTR and 6 bp ins/6 bp ins of TYMS at 5'UTR were found to be protective. " 03/01/2018 - "The T-A-A haplotype combination of MTHFR C677T, MTHFR A1298C and MTR A2756G as well as 3R- 152 bp of TYMS at 5'UTR and 3'UTR were also found to contribute significant risk for the onset of presbycusis. "
4.	5' Untranslated Regions (5' UTR)IBA 03/01/2018 - "The 'TT' genotype of MTHFR C677T and '152 bp/152 bp' genotype of TS1494indel6 bp showed statistically significant risk for presbycusis while CC genotype of MTHFR A1298C, '2R/2R' genotype of TSER at 3'UTR and 6 bp ins/6 bp ins of TYMS at 5'UTR were found to be protective. " 03/01/2018 - "The T-A-A haplotype combination of MTHFR C677T, MTHFR A1298C and MTR A2756G as well as 3R- 152 bp of TYMS at 5'UTR and 3'UTR were also found to contribute significant risk for the onset of presbycusis. "
5.	SolutionsIBA 05/01/2011 - "In conclusion, for the elderly people with the effects of hearing aids in presbycusis and due to the significant improvement in psychological state and mental functions, using and being adaptable to hearing aids is a good solution."
6.	Dexamethasone (Maxidex)FDA LinkGeneric 10/01/2011 - "To determine whether intratympanic (i.t.) dexamethasone ameliorates cisplatin-induced ototoxicity in a mouse model of presbycusis. "
7.	Cisplatin (Platino)FDA LinkGeneric 10/01/2011 - "To determine whether intratympanic (i.t.) dexamethasone ameliorates cisplatin-induced ototoxicity in a mouse model of presbycusis. "
8.	Mitochondrial DNA (mtDNA)IBA 07/01/2019 - "Eight English and Chinese studies were included in the meta-analysis, the results of which showed that mitochondrial DNA 4977 bp deletion could increase the risk of presbycusis (OR = 8.16, 95% CI: 3.51-18.99), and the difference was statistically significant (P <. " 07/01/2019 - "This study aimed to assess the differences of mtDNA 4977 bp deletion between presbycusis patients and controls by conducting a meta-analysis of published studies. " 01/01/2016 - "The findings of this study suggest that lower mitochondrial DNA copy number is responsible for presbycusis through alteration of mitochondrial function. " 07/01/1997 - "The current study demonstrates the presence of a 4,977 bp deletion in human mitochondrial DNA genome that is associated with aging and with some forms of presbycusis. " 07/01/1997 - "The current study examined mitochondrial DNA (mtDNA) from cochlear sections of 34 human temporal bones: 17 with normal hearing and 17 with presbycusis. "
9.	Galactose (Galactopyranose)FDA LinkGeneric 07/01/2015 - "The purpose of this study was to explore the association between Trx2 and the phenotype of central presbycusis using a mimetic aging animal model induced by long-term exposure to d-galactose (d-Gal). " 01/01/2014 - "In this study, the mechanisms of central presbycusis were investigated using a mimetic aging rat model induced by chronic injection of D-galactose (D-Gal). " 08/01/2011 - "The current study was designed to investigate potential causative mechanisms of central presbycusis by using a rat mimetic aging model induced by subcutaneous administration of D-galactose (D-gal). " 07/16/2010 - "The current study was designed to investigate potential causative mechanisms of this impairment by using a rat model in which presbycusis is inducible by administration of D-galactose (D-gal). " 01/01/2023 - "We aimed to establish a D-galactose (D-gal)-induced SMCs senescent model and study the effect of deacetylase sirtuin 1 (SIRT1) on presbycusis in vitro. "
10.	Biomarkers (Surrogate Marker)IBA 01/01/2022 - "Our study aimed to determine the pathological mechanism of presbycusis at the molecular level, and determine potential biomarkers for the same. " 05/01/2018 - "Identification of novel biomarkers for presbycusis. " 01/01/2021 - "Because EEGs are commonly recorded in humans, the mouse data may serve as translation relevant preclinical biomarkers to facilitate the development of therapeutics to delay or reverse central auditory processing deficits in presbycusis." 01/01/2021 - "Conclusion: This study highlighted differences in static and dynamic functional connectivity in patients with presbycusis and suggested that FNC may serve as an important biomarker of cognitive performance since abnormal alterations can better track cognitive impairment in presbycusis." 12/01/2022 - "These findings enriched our understanding of the neural mechanisms underlying cognitive impairments associated with presbycusis and may serve as a potential imaging biomarker for investigating and predicting cognitive difficulties."

Therapies and Procedures

1.	Hearing Aids (Hearing Aid) 05/20/2016 - "Result:After the hearing aid of moderate presbycusis, The improved value of monosyllabic words and recognition rate in quite and noise statement(SNR=5) were 31.15%, 23.21%, 44.11%.However, improved values in severe presbycusis were 37.51%, 48.47%，50.17%, before and after hearing aid, the difference of the improved average value was statistically significant(P <0.05); Both the moderate and severe presbycusis were satisfacted with hearing aid.The" 07/01/2009 - "In conclusion, with respect to the beneficial effects of hearing aids in presbycusis and due to the significant improvement in the quality of life, hearing aids are recommended for this group of population." 09/01/1977 - "Many people with presbycusis are helped by hearing aids but all of them are helped by good enunciation. " 01/01/2022 - "Importantly, recent studies show that the use of hearing aids in presbycusis, which is its standard management, can induce neuroplasticity and modify performance in cognitive tests. " 05/01/2021 - "The main aim of the present study was to evaluate the benefit of first-time hearing aids (HA) for emotional prosody perception in presbycusis patients. "
2.	Therapeutics 11/01/2022 - "The patients without presbycusis showed a significant improvement in the functional communication measurement (FCM) level and maximum phonation time (MPT) compared with those of patients with presbycusis after voice therapy. " 02/01/2021 - "Hearing amplification is the mainstay of treatment for presbycusis, but adherence with this therapy remains abysmally low, necessitating the exploration of other treatment modalities. " 11/01/2022 - "The improvement in the FCM level and MPT after voice therapy was relatively low if patients with presbycusis accompanied by presbycusis. " 09/15/2012 - "Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy." 05/07/2008 - "Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment for presbycusis, for which there is no effective therapy."
3.	Lipreading (Lip Reading) 12/30/2017 - "Both in individuals with presbycusis and controls, speechreading significantly improved speech discrimination (p<.001<.05); however, compared to controls, this effect of speechreading on speech discrimination was more pronounced in individuals with presbycusis (p<.001). " 11/01/2016 - "To evaluate whether the intelligibility of words in presbycusis is improved by speechreading, in such a way that looking at the interlocutor's face while he is talking functions like a "third ear", and to determine the statistical relevance of the intelligibility improvement by speechreading. " 12/30/2017 - "Thus, in individuals with presbycusis, this study determined whether speechreading would improve word intelligibility. " 11/01/2016 - "Individuals with presbycusis in this study, performed better on spoken word intelligibility when the hearing of those words was associated with speechreading. " 11/01/2016 - "In the literature no studies exist concerning the importance of speechreading in individuals with presbycusis. "
4.	Transplantation 01/01/2013 - "Intracerebral neural stem cell transplantation improved the auditory of mice with presbycusis." 01/01/2013 - "Together, our results demonstrate that NSCs transplantation improve the auditory of C57BL/6J mice with presbycusis." 01/01/2013 - "Here, we assess the capability of intracerebral embryonic NSCs transplantation for C57BL/6J mice with presbycusis in vivo. " 11/20/2006 - "Transfer of accelerated presbycusis by transplantation of bone marrow cells from senescence-accelerated mice."
5.	Cochlear Implants (Cochlear Implant) 11/01/2013 - "Further studies and more experience with more patients and pathological conditions such as plasticity of the auditory system, cochlear implants, hearing aids, presbycusis, or acoustic neuropathy are necessary until this type of testing is ready for clinical application." 01/01/2010 - "Hearing aids and cochlear implants (CIs) are the most commonly used devices for treating mild-severe presbycusis. " 06/01/2011 - "The further technical development of cochlear implants has now widened their indications to include severe congenital deafness and presbycusis." 01/01/2010 - "A PubMed literature search was conducted using the keywords 'presbycusis/presbyacusis/geriatric AND hearing aids/cochlear implants/electric acoustic stimulation/middle ear implants' and 'elderly AND cochlear implants'. " 04/01/2013 - "The prevailing otolaryngologic approach to treatment of age-related hearing loss (ARHL), presbycusis, emphasizes compensation of peripheral functional deficits (ie, hearing aids and cochlear implants). "