Prenylamine

A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)

Also Known As:

Corontin; Difril; Segontin; Benzenepropanamine, N-(1-methyl-2-phenylethyl)-gamma-phenyl-

Networked: 106 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - Prenylamine: 106
        prenylamine lactate: 7
        droprenylamine: 2
        prenyl-1,2-naphthohydroquinone: 1

Experts

1.	Adye, Daya Raju: 1 article (02/2022)
2.	Bharatam, Prasad V: 1 article (02/2022)
3.	Borkar, Roshan M: 1 article (02/2022)
4.	Dubey, Sachin: 1 article (02/2022)
5.	Hirlekar, Bhakti Umesh: 1 article (02/2022)
6.	Joseph, Athira: 1 article (02/2022)
7.	Konda, Satyanand: 1 article (02/2022)
8.	Kumar, Gangasani Jagadeesh: 1 article (02/2022)
9.	Kumar, Pramod: 1 article (02/2022)
10.	Mudiam, Mohana Krishna Reddy: 1 article (02/2022)

Related Diseases

1.	Cardiotoxicity 01/01/1987 - "Prenylamine (PNL), a calcium antagonistic drug, provided partial protection against ADM-induced cardiotoxicity in mice and in the rabbit. " 01/01/1988 - "Experimental and clinical trials to determine the potential of prenylamine in the prevention of adriamycin-related cardiotoxicity are reviewed. " 01/01/1988 - "The mechanisms of adriamycin-related cardiotoxicity, the effects of prenylamine and the benefit from combined treatment are discussed." 01/01/1988 - "The role of prenylamine in the prevention of adriamycin-induced cardiotoxicity. " 01/01/1987 - "Prevention of adriamycin-induced cardiotoxicity by prenylamine: a pilot double blind study."
2.	Ventricular Fibrillation 05/01/1979 - "Protective effect of prenylamine against vulnerability to ventricular fibrillation in the normal and ischemic canine myocardium." 07/31/1976 - "[Long QT, syncope caused by atypical ventricular fibrillation and chronic ingestion of prenylamine (review of the literature and report of a case]." 09/01/1984 - "Death was due in prenylamine-treated rats to atrioventricular block leading to asystole whereas in those administered verapamil or flunarizine it was a consequence of persistent ventricular fibrillation. " 07/01/1967 - "Control of ventricular fibrillation during induced hypothermia in cats after differential depletion of cardiac catecholamine stores with prenylamine (Segontin)." 01/01/1985 - "Thus, inhibition of the fast inward sodium channel with agents such as prenylamine and lignocaine, (when begun before coronary-artery occlusion) offers maximal protection against reperfusion-induced ventricular fibrillation, while beta-blockade with timolol and oxprenolol and slow calcium channel inhibition with nifedipine do not offer any significant protection. "
3.	Urticaria (Hives) 02/01/1981 - "[Management of chronic urticaria with prenylamine]."
4.	Angina Pectoris 01/01/1985 - "This study was performed to re-evaluate the clinical position of prenylamine in the management of angina pectoris. " 07/01/1971 - "A double-blind, double cross-over trial of prenylamine in angina pectoris." 12/01/1970 - "A 2-year study of the efficacy and tolerability of prenylamine in the treatment of angina pectoris." 11/01/1980 - "The effect of prenylamine on the QT interval of the resting electrocardiogram in patients with angina pectoris." 09/01/1968 - "Effect of prenylamine in angina pectoris."
5.	Coronary Disease (Coronary Heart Disease) 11/26/1976 - "Moreover, Segontin 60 mg is the preparation of choice if the coronary heart disease is accompanied by tachyarrhythmic and hyperkinetic symptoms." 11/26/1976 - "62 patients with coronary heart disease were treated with Segontin 60 mg for periods of 6 months to 8 years in a specialist internal medical practice. " 11/26/1976 - "[Longterm treatment of coronary heart disease with Segontin (author's transl)]." 04/15/1966 - "[Corontin in coronary disease]." 08/01/1962 - "[Experiences with the clinical use of Segontin in coronary disease]."

Related Drugs and Biologics

1.	Nifedipine (Adalat)
2.	Calcium
3.	Calcium Channels (Calcium Channel)
4.	Lidocaine (Xylocaine)
5.	Sodium Channels (Sodium Channel)
6.	Timolol (Blocadren)
7.	Oxprenolol (Trasicor)
8.	Digoxin (Digitek)
9.	Verapamil (Calan)
10.	Gallopamil (D600)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Therapeutics
3.	Intravenous Injections
4.	Microelectrodes
5.	Medication Errors (Medication Error)