|5.||Sleep Apnea Syndromes (Sleep Apnea)
|1.||Butler, Merlin G: 18 articles (08/2015 - 06/2003)|
|2.||Grugni, Graziano: 16 articles (05/2015 - 10/2005)|
|3.||Wevrick, Rachel: 14 articles (08/2015 - 03/2003)|
|4.||Hokken-Koelega, Anita C S: 13 articles (09/2015 - 04/2009)|
|5.||Driscoll, Daniel J: 12 articles (08/2015 - 06/2002)|
|6.||Höybye, Charlotte: 12 articles (04/2015 - 05/2003)|
|7.||Jin, Dong-Kyu: 12 articles (07/2012 - 08/2004)|
|8.||Hokken-Koelega, A C S: 10 articles (12/2015 - 12/2006)|
|9.||Haqq, Andrea M: 10 articles (10/2015 - 01/2003)|
|10.||Grugni, G: 10 articles (08/2015 - 04/2000)|
|1.||Growth Hormone (Somatotropin)IBA
01/01/2015 - "Growth hormone (GH) treatment is beneficial for children with Prader-Willi syndrome (PWS), but data about health-related quality of life (HRQOL) and effects of GH treatment are scarce. "
08/01/2002 - "In Prader-Willi syndrome, 2 years of growth hormone therapy also induced a sustained decrease in body fat, improvement in strength and physical skills, and increased lean body mass. "
08/01/2011 - "Growth hormone treatment for two years is safe and effective in adults with Prader-Willi syndrome."
03/01/2013 - "Are sleep studies helpful in children with Prader-Willi syndrome prior to commencement of growth hormone therapy?"
02/01/2013 - "Growth hormone therapy for children and adolescents with Prader-Willi syndrome is associated with improved body composition and metabolic status in adulthood."
|2.||Oxytocin (Pitocin)FDA LinkGeneric
09/01/2014 - "Individuals with Prader-Willi syndrome (PWS) have a significant reduction in the number of oxytocin-producing neurons (42%) in the hypothalamic paraventricular nucleus. "
01/01/2011 - "Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: a randomised placebo-controlled trial in 24 patients."
02/01/1995 - "Alterations in the hypothalamic paraventricular nucleus and its oxytocin neurons (putative satiety cells) in Prader-Willi syndrome: a study of five cases."
07/15/2015 - "MAGEL2 and Oxytocin-Implications in Prader-Willi Syndrome and Beyond."
09/01/2014 - "A double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome."
|3.||Human Growth Hormone (Saizen)FDA LinkGeneric
01/01/2004 - "Results of several somatropin (GH therapy) studies in children with Prader-Willi syndrome have shown improvement in growth, body composition, physical strength, and agility. "
01/01/2004 - "However, further studies are required to establish the definite role and optimal dosage of somatropin, as well as long-term effects, in adults with Prader-Willi syndrome."
01/01/2004 - "In conclusion, the one published study of somatropin therapy in adults with Prader-Willi syndrome showed beneficial effects on body composition without pronounced adverse effects. "
08/01/2013 - "Recombinant human growth hormone (hGH) therapy in children with Prader-Willi syndrome (PWS) improves linear growth, body composition, physical strength and agility, and other metabolic parameters. "
08/01/2013 - "Long-term effects of recombinant human growth hormone therapy in children with Prader-Willi syndrome."
|4.||modafinil (armodafinil)FDA Link
07/01/2011 - "Efficacy of modafinil on excessive daytime sleepiness in Prader-Willi syndrome."
01/01/2014 - "Long-term modafinil therapy may ameliorate the sleep disturbances of Prader-Willi syndrome and should be the focus of future clinical trials."
01/01/2014 - "In this case report we present a longitudinal perspective of sleep abnormalities in a nine-year-old Caucasian girl with Prader-Willi syndrome from age two to age nine, and detail the response to treatment with the central nervous system stimulant modafinil. "
|5.||Gonadal Steroid Hormones (Sex Hormones)IBA
|6.||Mazindol (Mazanor)FDA Link
11/01/1995 - "Mazindol may prove to be useful in the treatment of patients with Prader-Willi syndrome."
02/24/1997 - "A case of Prader-Willi syndrome with long-term mazindol treatment."
11/01/1995 - "Effects of mazindol in two patients with Prader-Willi syndrome."
11/01/1995 - "Two of 3 patients with Prader-Willi syndrome inhibited their body weight gain with mazindol. "
11/01/1995 - "We examined the effects of mazindol on 1) body weight, appetite, and abnormalities of obesity-related diseases in long-term use 2) maintenance of the reduced body weight after very-low-calorie diet (VLCD) therapy 3) combined use with VLCD therapy and, 4) inhibition of body weight gain in Prader-Willi syndrome. "
|7.||Guanfacine (Tenex)FDA LinkGeneric
|8.||Tryptophan (L-Tryptophan)FDA Link
04/01/2011 - "An 8-year old girl with Prader-Willi Syndrome presenting with excessive daytime sleepiness improved following treatment with tryptophan; possibly by consolidation of her fragmented sleep. "
04/01/2011 - "We conclude that tryptophan may be an useful medication for excessive sleepiness in children with Prader-Willi Syndrome."
04/01/2011 - "Tryptophan for the treatment of excessive daytime sleepiness in Prader-Willi syndrome."
|10.||Appetite Depressants (Anorectics)IBA
|1.||Gastric Bypass (Roux-en-Y Gastric Bypass)
04/01/2014 - "To test the efficacy of the mini-gastric bypass (MGB) in the treatment of morbid obesity related to the Prader-Willi Syndrome (PWS). "
04/01/2014 - "The mini-gastric bypass in the management of morbid obesity in Prader-Willi syndrome: a viable option?"
10/01/2003 - "Gastric bypass in a Japanese man with Prader-Willi syndrome and morbid obesity."
08/30/2006 - "Ghrelin levels are high in Prader-Willi syndrome and low after gastric bypass surgery, possibly contributing to body-weight alterations in these settings. "
03/01/2013 - "Laparoscopic sleeve gastrectomy in Chinese female patient with Prader-Willi syndrome and diabetes."
05/01/2009 - ""Efficacy of laparoscopic sleeve gastrectomy as a stand-alone technique for children with morbid obesity" and "BioEnterics intragastric balloon for treatment of morbid obesity in Prader-Willi syndrome: specific risks and benefits"."
11/01/2012 - "Ghrelin level and weight loss after laparoscopic sleeve gastrectomy and gastric mini-bypass for Prader-Willi syndrome in Chinese."
|3.||Transplantation (Transplant Recipients)
12/01/1995 - "Encouraging short-term results have been reported in patients with a few other conditions, such as patients with glucocorticoid-induced growth failure, renal transplantation, and Prader-Willi syndrome, but the data are limited and no long-term studies have been reported; in many other conditions the data are either inconclusive or discouraging. "
|4.||Psychophysiology (Physiological Psychology)
|5.||Language Therapy (Language Training)
03/01/2011 - "The aim of this study was to describe the trajectory and the outcomes of speech-language therapy in Prader-Willi syndrome through a longitudinal study of the case of an 8 year-old boy, along four years of speech-language therapy follow-up. "
03/01/2011 - "Trajectory and outcomes of speech language therapy in the Prader-Willi syndrome (PWS): case report."