Postgastrectomy Syndromes

Sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.

Also Known As:

Networked: 83 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer)
2.	Neoplasms (Cancer)
3.	Ulcer
4.	Peptic Ulcer (Peptic Ulcers)
5.	Gastritis

Experts

1.	Nakada, Koji: 17 articles (06/2022 - 06/2014)
2.	Oshio, Atsushi: 9 articles (06/2022 - 01/2015)
3.	Ikeda, Masami: 8 articles (05/2022 - 04/2003)
4.	Takahashi, Masazumi: 8 articles (01/2022 - 01/2015)
5.	Kodera, Yasuhiro: 8 articles (11/2021 - 01/2015)
6.	Yoshida, Masashi: 7 articles (06/2022 - 06/2014)
7.	Terashima, Masanori: 7 articles (05/2022 - 06/2014)
8.	Uenosono, Yoshikazu: 7 articles (05/2022 - 01/2015)
9.	Kinami, Shinichi: 7 articles (01/2022 - 01/2015)
10.	Kawashima, Yoshiyuki: 4 articles (05/2021 - 06/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Postgastrectomy Syndromes:

1.	GhrelinIBA 12/01/2013 - "In the patients with a baseline GSRS score of ≥2, rikkunshito significantly improved the symptoms of postgastrectomy syndrome, and its effect was possibly independent of the plasma ghrelin levels."
2.	liu-jun-zi-tangIBA 12/01/2013 - "In the patients with a baseline GSRS score of ≥2, rikkunshito significantly improved the symptoms of postgastrectomy syndrome, and its effect was possibly independent of the plasma ghrelin levels."
3.	Serotonin (5 Hydroxytryptamine)IBA 02/01/1968 - "[Effect of serotonin inactivators on the tryptophan serum level in patients with postgastrectomy syndromes]." 01/01/2004 - "To test the hypothesis that the changes in ileal smooth muscle contractility accompanying postgastrectomy syndromes are agonist-specific, we investigated the effects of potassium chloride (KCl), carbachol, substance P (SP), and serotonin on ileal smooth muscle contractility after total gastrectomy in rats. "
4.	Bile Acids and Salts (Bile Acids)IBA 09/01/1980 - "The hypothesis that reflux of upper intestinal content, particularly of bile acids (BA), is responsible for a unique postgastrectomy syndrome, alkaline reflux gastritis, was tested on 28 occasions in 21 postoperative patients (14 symptomatic patients, 7 controls). " 01/01/1979 - "Eight patients with severe postgastrectomy syndromes for predominantly bile reflux gastritis were examined by quantification of bile acids in the gastric remnant before and after a standardized liquid meal. "
5.	AntidiarrhealsIBA 10/01/1984 - "[An antiperistaltic duodenojejunal pouch in the reconstruction of digestive transit after subtotal and total gastrectomy and in the postgastrectomy syndrome. " 04/01/1984 - "[Antiperistaltic duodenojejunal pouch in the reconstruction of digestive transit after subtotal, total gastrectomy and in the postgastrectomy syndrome. "
6.	AcidsIBA 06/01/1975 - "[Acid-producing function of the gastric stump in patients with postgastrectomy syndromes]." 07/01/1964 - "THE EXCRETION OF 5-HYDROXYINDOLEACETIC ACID IN THE POSTGASTRECTOMY SYNDROME."
7.	VitaminsIBA 11/01/1973 - "[Vitamin metabolism in patients with ulcer disease and in postgastrectomy syndrome]."
8.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 12/01/1967 - "[The vitamin B 12 content, and protein composition of the blood serum in patients with postgastrectomy syndromes]."
9.	Tryptophan (L-Tryptophan)FDA Link 02/01/1968 - "[Effect of serotonin inactivators on the tryptophan serum level in patients with postgastrectomy syndromes]."
10.	Substance PIBA 01/01/2004 - "To test the hypothesis that the changes in ileal smooth muscle contractility accompanying postgastrectomy syndromes are agonist-specific, we investigated the effects of potassium chloride (KCl), carbachol, substance P (SP), and serotonin on ileal smooth muscle contractility after total gastrectomy in rats. "

Therapies and Procedures

1.	Gastrectomy 11/27/2021 - "We conducted a nationwide multi-institutional study using PGSAS-45 to examine the prevalence of postgastrectomy syndrome and its impact on daily lives of patients after various types of gastrectomy. " 04/01/2015 - "Long-term quality-of-life comparison of total gastrectomy and proximal gastrectomy by postgastrectomy syndrome assessment scale (PGSAS-45): a nationwide multi-institutional study." 09/01/2023 - "In the case of dysplasia, prophylactic total gastrectomy is recommended, but because it is highly invasive and postoperative postgastrectomy syndrome must be considered, the decision should be made with careful consideration of the patient's background. " 08/01/2023 - "Outcomes were measured using the Postgastrectomy Syndrome Assessment Scale-45, which was specifically developed to measure post-gastrectomy symptoms, living status, dissatisfaction with daily life and generic QOL. " 05/01/2023 - "Quality of life comparison between esophagogastrostomy and double tract reconstruction for proximal gastrectomy assessed by Postgastrectomy Syndrome Assessment Scale (PGSAS)-45."
2.	Gastroenterostomy 11/07/2013 - "Efferent loop syndrome is a very rare postgastrectomy syndrome that can occur following Billroth-II or Roux-en-Y reconstruction. " 09/01/1970 - "[Postgastrectomy syndrome in the Billroth II. Polya-Hoffmeister technic]." 04/01/1961 - "A case of interposition for postgastrectomy syndrome following the Billroth II operation." 04/01/2017 - "The aim of this study was to assess postgastrectomy syndrome and QOL after LAPPG as compared with laparoscopy-assisted distal gastrectomy with Billroth-I reconstruction (LADGBI). " 08/01/1984 - "A study of 118 patients, operated on with Billroth II gastrectomy for peptic disease and affected by postgastrectomy syndromes, was carried out. "
3.	Therapeutics 04/01/1990 - "[The clinical picture and therapy of postgastrectomy syndromes]." 01/01/1969 - "[Clinical aspects, classification and therapy of postgastrectomy syndromes]." 01/01/1992 - "The analysis of these postgastrectomy syndromes is an opportunity to discuss about the failure factors in the surgery of the gastric and duodenal ulcer, the possibilities of exploration and the principles which should guide the reparative therapy." 01/01/2006 - "In order to understand entirely the influence of peptic ulcer surgery on the GI function, further research of the role of specific hormones and neuropeptides is needed, which would enable more precise selection of the therapy in order to prevent postvagotomy and postgastrectomy syndromes."
4.	Operative Time 10/01/1979 - "By the use of the stapling devices, a large spectrum of postgastrectomy syndromes can be managed with minimal manipulation and dissection, shortened operative time, decreased blood loss and spillage, and reduced morbidity while attaining uniformly good amelioration of symptoms. "
5.	Gastroplasty (Vertical-Banded Gastroplasty) 11/01/2015 - "Gastroplasty, using ileo-cecal intestinal segment, have promoted reduction of the remote postgastrectomy syndromes occurrence rate from 58.8 to 11.1%. "