Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)

A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.
Also Known As:
Familial Adenomatous Polyposis; Adenomatous Polyposis of the Colon; Adenomatous Polyposis Coli, Familial; Familial Adenomatous Polyposis Coli; Familial Adenomatous Polyposis of the Colon; Familial Intestinal Polyposis; Familial Multiple Polyposi; Familial Polyposis Coli; Familial Polyposis of the Colon; Hereditary Polyposis Coli; Polyposis, Adenomatous Intestinal; Adenomatous Intestinal Polyposes; Adenomatous Intestinal Polyposis; Adenomatous Polyposes, Familial; Adenomatous Polyposis Colus; Adenomatous Polyposis, Familial; Coli, Adenomatous Polyposis; Coli, Familial Polyposis; Coli, Hereditary Polyposis; Colus, Adenomatous Polyposis; Colus, Familial Polyposis; Colus, Hereditary Polyposis; Familial Adenomatous Polyposes; Familial Intestinal Polyposes; Familial Multiple Polyposus; Familial Polyposis Colus; Familial Polyposis Syndrome; Familial Polyposis Syndromes; Hereditary Polyposis Colus; Intestinal Polyposes, Familial; Intestinal Polyposis, Adenomatous; Intestinal Polyposis, Familial; Multiple Polyposi, Familial; Multiple Polyposus, Familial; Polyposes, Familial Adenomatous; Polyposi, Familial Multiple; Polyposis Coli, Adenomatous; Polyposis Coli, Hereditary; Polyposis Colus, Adenomatous; Polyposis Colus, Familial; Polyposis Colus, Hereditary; Polyposis, Familial Adenomatous; Polyposus, Familial Multiple; Polyposis Coli, Familial; Polyposis Syndrome, Familial
Networked: 2205 relevant articles (46 outcomes, 223 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Polyps
2. Adenoma (Adenomas)
3. Ulcerative Colitis
4. Neoplasms (Cancer)
5. Colonic Neoplasms (Colon Cancer)


1. Giardiello, Francis M: 16 articles (02/2015 - 03/2002)
2. Akiyama, Tetsu: 14 articles (04/2015 - 06/2002)
3. Yang, Vincent W: 11 articles (09/2012 - 04/2002)
4. Phillips, Robin K S: 11 articles (05/2011 - 01/2004)
5. Nagengast, Fokko M: 10 articles (01/2013 - 11/2006)
6. Phillips, R K S: 10 articles (04/2012 - 05/2002)
7. Hylind, Linda M: 10 articles (06/2011 - 03/2002)
8. Jones, David A: 10 articles (08/2009 - 08/2004)
9. Behrens, Jürgen: 9 articles (02/2014 - 01/2004)
10. Nakamura, Y: 9 articles (01/2014 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adenomatous Polyposis Coli:
1. celecoxib (Celebrex)FDA Link
2. Sulindac (Copal)FDA LinkGeneric
3. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
4. Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
5. Indomethacin (Indometacin)FDA LinkGeneric
6. Cyclooxygenase 2 (Cyclooxygenase-2)IBA
7. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
8. DNA (Deoxyribonucleic Acid)IBA
9. beta CateninIBA
10. Codon (Codons)IBA

Therapies and Procedures

1. Restorative Proctocolectomy
2. Colectomy
3. Chemoprevention
4. Ileostomy
5. Drug Therapy (Chemotherapy)