Polyribonucleotide Nucleotidyltransferase (Polynucleotide Phosphorylase)

An enzyme of the transferase class that catalyzes the reaction RNA(n+1) and orthophosphate to yield RNA(n) and a nucleoside diphosphate, or the reverse reaction. ADP, IDP, GDP, UDP, and CDP can act as donors in the latter case. (From Dorland, 27th ed) EC 2.7.7.8.

Also Known As:

Networked: 30 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fisher, Paul B: 7 articles (01/2013 - 07/2003)
2.	Sarkar, Devanand: 7 articles (01/2013 - 07/2003)
3.	Lebedeva, Irina V: 3 articles (05/2008 - 07/2003)
4.	Das, Swadesh K: 2 articles (01/2013 - 06/2010)
5.	Emdad, Luni: 2 articles (01/2013 - 10/2004)
6.	Sokhi, Upneet K: 2 articles (01/2013 - 06/2010)
7.	Valerie, Kristoffer: 2 articles (05/2008 - 07/2003)
8.	Clements, Mark O: 2 articles (02/2006 - 06/2002)
9.	Hinton, Jay C D: 2 articles (02/2006 - 06/2002)
10.	Rhen, Mikael: 2 articles (02/2006 - 06/2002)

Related Diseases

1.	Tuberculosis (Tuberculoses) 01/01/2023 - "Since recent studies with the key tuberculosis persister drug pyrazinamide have implicated polynucleotide phosphorylase (PNPase) as a drug target, in this study, we addressed the possibility that PNPase might be involved in persistence in Escherichia coli. "
2.	Melanoma (Melanoma, Malignant) 01/01/2013 - "Identification of genes potentially regulated by human polynucleotide phosphorylase (hPNPase old-35) using melanoma as a model." 06/29/2010 - "Human polynucleotide phosphorylase selectively and preferentially degrades microRNA-221 in human melanoma cells." 09/01/2006 - "Defining the mechanism by which IFN-beta dowregulates c-myc expression in human melanoma cells: pivotal role for human polynucleotide phosphorylase (hPNPaseold-35)." 07/04/2003 - "Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells."
3.	Starvation 03/02/2010 - "Examination of rRNA profiles reveals that Rsr, the 3' to 5' exoribonuclease polynucleotide phosphorylase (PNP) and additional nucleases are all involved in the extensive rRNA decay that occurs during starvation of this bacterium. " 01/10/1974 - "The involvement of ribonuclease I, ribonuclease II, and polynucleotide phosphorylase in the degradation of stable ribonucleic acid during carbon starvation in Escherichia coli." 02/01/1977 - "During carbon starvation at elevated temperatures, mutants deficient in ribonuclease I do not form oligonucleotides and 3'-nucleoside monophosphates, and mutants that contain a modified form of polynucleotide phosphorylase do not accumulate nucleoside diphosphates. "
4.	Sarcoma (Soft Tissue Sarcoma) 04/01/1986 - "The capacity of the partially purified preparation of the polynucleotide phosphorylase releasing factor (PNP-ase RF) from Walker sarcoma for stimulating the growth of hybrid cells and parent myeloma cells has been studied. " 03/01/1980 - "[Purification and properties of a releasing factor of polynucleotide phosphorylase from sarcoma M-1 of rat]." 12/01/1976 - "Specific activity and level of polynucleotide phosphorylase (PNPase) in polyribosomes of regenerating liver of adult rats, liver of newborn rats and in malignant tumours of rat (sarcoma M-1 and hepatoma 27) were studied. " 03/01/1980 - "A releasing factor (RF) of polynucleotide phosphorylase (PNPase) isolated and purified from sarcoma M-1 of the rat is a protein with molecular weight of about 8000 and the isoelectric point at 4,0--4,2. "
5.	Neoplasms (Cancer) 05/01/2008 - "Employing an overlapping pathway screen to identify genes exhibiting coordinated expression as a consequence of terminal cell differentiation and replicative senescence, we identified human polynucleotide phosphorylase (hPNPase(old-35)), a 3',5'-exoribonuclease that exhibits robust growth-suppressing effects in a wide spectrum of human cancers. " 05/01/2008 - "Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppression." 11/01/1961 - "On the nucleotide specificity of the polynucleotide phosphorylase of the crown-gall tumor-inducing organism Agrobacterium tumefaciens." 04/01/1961 - "Adenine nucleotide breakdown and its relationship to polynucleotide phosphorylase in the crown-gall tumor inducing organism Agrobacterium tumefaciens."

Related Drugs and Biologics

1.	Pyrazinamide
2.	Exoribonucleases
3.	RNA (Ribonucleic Acid)
4.	Pancreatic Ribonuclease (Ribonuclease A)
5.	Carbon
6.	exoribonuclease II
7.	23S Ribosomal RNA
8.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
9.	Diphosphates (Pyrophosphates)
10.	Proteins (Proteins, Gene)