|1.||van Haandel, Leon: 2 articles (12/2014 - 04/2012)|
|2.||Becker, Mara L: 2 articles (12/2014 - 04/2012)|
|3.||Kodama, Yukinobu: 2 articles (04/2014 - 02/2012)|
|4.||Kurosaki, Tomoaki: 2 articles (04/2014 - 02/2012)|
|5.||Sasaki, Hitoshi: 2 articles (04/2014 - 02/2012)|
|6.||Barclay, Murray L: 2 articles (03/2014 - 12/2011)|
|7.||Zhang, Mei: 2 articles (03/2014 - 12/2011)|
|8.||Stamp, Lisa K: 2 articles (03/2014 - 12/2011)|
|9.||Drake, Jill: 2 articles (03/2014 - 12/2011)|
|10.||Usui, Taichi: 2 articles (12/2013 - 02/2007)|
08/01/1997 - "In this study, we examined the basis for differences between long chain MTX polyglutamate accumulation between different leukemia cell types using both leukemia cell lines and blasts freshly isolated from blood of leukemic patients. "
01/01/1997 - "Decreased methotrexate (MTX) long-chain polyglutamate formation is associated with MTX resistance whereas high levels of MTX polyglutamate accumulation are found in the blasts of leukemia patients who respond to therapy and have improved outcome. "
04/30/1991 - "Two sublines of the human T-lymphoblast leukemia cell line CCRF-CEM, which were resistant to methotrexate (MTX) due to defective MTX polyglutamate synthesis, were karyologically characterized. "
01/01/1991 - "None of these compounds were metabolized to the respective polyglutamate derivative as judged by their inability to serve as substrates for CCRF-CEM human leukemia cell folylpolyglutamate synthetase (FPGS) in vitro. "
08/01/1997 - "In contrast to MTX, both Tomudex (Zeneca Pharmaceuticals, Wilmington, DE) and 1843U89, potent inhibitors of thymidylate synthetase, have low Kms for folylpolyglutamate synthetase, and polyglutamate forms of these inhibitors are accumulated to the same degree in both myeloid and lymphoid acute leukemia cells, paralleling the equivalent cytotoxicity found between myeloid and lymphoid leukemia cell lines. "
03/01/2012 - "The short-chain polyglutamate MTXPG2 revealed to be a potential marker for clinical outcome in rheumatoid arthritis with a statistically significant positive correlation of MTXPG2 Cmax levels and improvement in DAS-28 (+0.518, p=0.023) over 16 weeks. "
10/30/2011 - "The highest observed glutamylation degree of MTX was MTXPG5, the very long chain MTX-polyglutamate metabolites MTXPG6 and MTXPG7 were not detected in the packed erythrocyte pellets collected from rheumatoid arthritis patients."
12/01/2011 - "To determine the effects of changing from oral to subcutaneous (SC) methotrexate (MTX) in patients with rheumatoid arthritis (RA) on red blood cell MTX polyglutamate (RBC MTXGlu(n)) concentrations, disease activity, and adverse effects. "
10/30/2011 - "After validation, the new method was used in the measurement of intracellular erythrocyte concentrations of MTX and MTX-polyglutamate metabolites (MTXPG2 to MTXPG7) in packed human erythrocyte samples collected from patients with rheumatoid arthritis receiving low-dose oral methotrexate therapy. "
10/01/2002 - "In patients with rheumatoid arthritis (RA), we examined whether methotrexate (MTX) and MTX polyglutamate accumulation in the liver correlated with clinical efficacy or clinical/laboratory toxicity. "
03/01/1989 - "However, pharmacologic activity may be expressed in high-dose MTX protocols when high blood levels of 7-OH-MTX are sustained over long intervals to the extent to which polyglutamate congeners accumulate in tumor cells and add to the much more potent inhibitory effects of MTX polyglutamates already present. "
01/01/1989 - "In contrast, only modest pool size expansion (148-164% of control) and limited modulation of polyglutamate species were detected in four tumor lines during infusion with [6RS]5-CH3-H4PteGlu. "
09/01/1984 - "Also, no correlation between the extent of polyglutamate formation and plasma levels (determined at the time of tumor sampling) was observed. "
01/01/1984 - "Polyglutamate accumulation for all the analogs was greater in tumor cells, but accumulation of each varied between the two tumors (L1210 and S180) examined. "
01/01/1983 - "However, differences in total drug persistence and sensitivity to drug among tumor cells and among normal tissues did not reflect the relative extent of polyglutamate synthesis in each group. "
|4.||Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
12/01/2014 - "This study was undertaken to evaluate circulating folate content and folate polyglutamate distribution in juvenile idiopathic arthritis (JIA) patients and in a cell culture model based on MTX exposure and folate supply. "
01/01/2005 - "Adenosine and MTX-polyglutamate concentrations in erythrocytes (EMTX) were assessed in venous blood samples taken before the next MTX dose in 30 patients treated long-term for juvenile idiopathic arthritis (JIA) and in 16 untreated matched controls. "
|5.||Small Cell Lung Carcinoma (Small Cell Lung Cancer)
|2.||Folic Acid (Vitamin M)
|4.||Prostaglandins A (PGA)
|5.||Leucovorin (Folinic Acid)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)