|1.||Szabó, Csaba: 18 articles (08/2013 - 02/2002)|
|2.||Cuzzocrea, Salvatore: 14 articles (07/2011 - 08/2002)|
|3.||Mazzon, Emanuela: 11 articles (07/2011 - 08/2002)|
|4.||Szabo, Csaba: 10 articles (01/2015 - 02/2002)|
|5.||Pacher, Pál: 10 articles (08/2013 - 02/2002)|
|6.||Virág, László: 9 articles (04/2015 - 02/2002)|
|7.||Swanson, Raymond A: 9 articles (02/2014 - 07/2002)|
|8.||Di Paola, Rosanna: 9 articles (07/2011 - 08/2002)|
|9.||Liaudet, Lucas: 8 articles (05/2014 - 02/2002)|
|10.||Bürkle, Alexander: 8 articles (01/2013 - 04/2002)|
01/01/2015 - "Inhibitors of poly (ADP-ribose) polymerase-1 (PARP-1) enzyme are useful for the treatment of various diseases including cancer. "
01/01/2014 - "Inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) have shown to be promising in clinical trials against cancer and other diseases, and lots of efforts have been put into the development of organic compounds as more potent PARP-1 inhibitors. "
12/03/2015 - "A burst of poly(ADP-ribose) synthesis initiates DNA damage response, whereas PARP-1 inhibition kills BRCA-deficient tumor cells selectively, providing the first anti-cancer therapy based on synthetic lethality. "
12/01/2015 - "Inhibition of Poly(ADP-ribose) Polymerase1 (PARP1) impairs DNA damage repair, and early generation PARP1/2 inhibitors (olaparib, niraparib, etc.) have demonstrated clinical proof of concept for cancer treatment. "
10/01/2015 - "[From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy]."
05/01/2009 - "The findings of the studies on poly(ADP-ribose) polymerase-1 (PARP-1) have suggested that the enzyme inactivation provides significant protection against systemic or tissue inflammation in animal models. "
05/01/2009 - "It has been suggested that inhibition of poly (ADP-ribose) polymerase-1 (PARP-1), either pharmacologically or by a gene knockout provides significant protection against systemic or tissue inflammation in animal models. "
04/23/2015 - "(2015) identify poly(ADP-ribose) as a new signaling molecule that activates inflammation, thus providing yet another mechanism by which PARPs are involved in cellular stress responses. "
12/01/2013 - "Poly(ADP-ribose) polymerase-1 (PARP-1) is required for both AIF release from mitochondria and NF-κB-mediated inflammation. "
01/01/2013 - "Taken together, our results show that DPQ treatment inhibits NF-κB signaling in macrophages and protects mice against ALI induced by LPS, suggesting inhibition of Poly (ADP-ribose) polymerase-1 may be a potential and effective approach to resolve inflammation for the treatment of ALI. "
08/01/2013 - "The aim of the present study was to investigate the molecular mechanism of this phenomenon (often termed 'two-hit' injury paradigm), in an in vitro model of hypoxia/oxidative stress injury in A549 epithelial cells, with special emphasis on the role of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1) in the process. "
03/01/2012 - "Previous studies have provided evidence for an interplay between the hypoxia-inducible factor-1 (HIF-1) and poly(ADP-ribose) polymerase-1 (PARP-1) under hypoxia. "
10/01/2011 - "Cytopathic hypoxia was studied using poly (ADP-ribose) polymerase-1 (PARP-1) gene knockout mice. "
01/01/1999 - "Protection against hypoxia-reoxygenation in the absence of poly (ADP-ribose) synthetase in isolated working hearts."
10/01/2015 - "Poly (adenosine diphosphate ribose) polymerase cleavage was induced by hypoxia or lactate treatment. "
07/01/2015 - "To evaluate the poly (ADP-ribose) polymerase-1 (PARP1) enzyme and its inhibition in horses and explore its potential as a novel therapeutic target for equine intestinal ischemia-reperfusion injury by (1) identifying poly (ADP-ribose) (PAR) as an indication of PARP1 activation in equine cells using available immunoblot analytical techniques, (2) inducing PARP1 activation in an in vitro oxidative DNA damage model, (3) and demonstrating the inhibition of PARP1 in equine cells using commercially available PARP1 inhibitors. "
04/01/2004 - "Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury."
05/01/2003 - "Poly(ADP-ribose) polymerase-1 (PARP-1) is activated in response to DNA injury in eukaryotic cells and has been implicated in cell dysfunction in reperfusion injury. "
05/01/2003 - "The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury."
03/01/2004 - "Poly(ADP-ribose) polymerase-1 (PARP-1), a monomeric nuclear enzyme present in eukaryotes, plays a role in cell death, inflammatory mediator expression, and mononuclear cell recruitment in various experimental models of inflammation and reperfusion injury. "
09/02/2011 - "Overactivation of poly (ADP-ribose) polymerase-1 (PARP-1) in response to DNA damage is considered to play a crucial role in the development of post-ischemic neuronal injury, such as ischemic stroke. "
04/01/2011 - "Sex differences in the response to poly(ADP-ribose) polymerase-1 deletion and caspase inhibition after stroke."
01/01/2011 - "In stroke, poly (ADP-ribose) polymerase-1 and heat shock protein-70 were cleaved to canonical proteolytic "signature" fragments by Gra-b. "
06/05/2015 - "Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke."
04/01/2015 - "MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor that competes with the binding of the PARP substrate nicotinamide adenine dinucleotide (NAD), is being developed as a neuroprotective agent against acute ischemic stroke. "
|2.||DNA (Deoxyribonucleic Acid)
|5.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|6.||Nitric Oxide (Nitrogen Monoxide)
|7.||Peroxynitrous Acid (Peroxynitrite)
|8.||Proteins (Proteins, Gene)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)
|4.||Deep Hypothermia Induced Circulatory Arrest