|5.||Acute Lung Injury
|1.||Kuca, Kamil: 64 articles (01/2016 - 01/2004)|
|2.||Eddleston, Michael: 54 articles (12/2015 - 01/2002)|
|3.||Worek, Franz: 45 articles (02/2015 - 01/2003)|
|4.||Kassa, Jiri: 43 articles (04/2015 - 07/2005)|
|5.||Thiermann, Horst: 43 articles (02/2015 - 01/2003)|
|6.||Hoffman, Robert S: 40 articles (08/2015 - 08/2002)|
|7.||Mégarbane, Bruno: 37 articles (11/2015 - 01/2002)|
|8.||Musilek, Kamil: 35 articles (01/2016 - 03/2006)|
|9.||Baud, Frédéric J: 34 articles (09/2014 - 01/2002)|
|10.||Eyer, Peter: 30 articles (06/2013 - 01/2003)|
|1.||Atropine (Hyoscyamine)FDA LinkGeneric
06/01/2014 - "Cases of organophosphate poisoning treated with high-dose of atropine in an intensive care unit and the novel treatment approaches."
06/01/2013 - "This study aimed to clarify the efficacy of 2 therapies for patients with severe acute organophosphorus pesticide poisoning, including atropine adverse effects, the length of intensive care unit (ICU) stay, complications, and mortality. "
07/01/2015 - "The objectives of our study were to measure serum CPK level, correlate CPK levels with severity of poisoning and estimate atropine dose used. "
03/01/2014 - "In this study, sixty-four OP-poisoning patients, all of whom accepted routine treatments but who did not attain atropinization after high doses of atropine for 12 h, were enrolled. "
06/01/2012 - "A study was therefore undertaken to determine the optimal dosing regimen for atropine in the treatment of OPC poisoning. "
01/01/2002 - "Since the changeover in the gas used in domestic appliances, the prevalence of acute carbon monoxide (CO) poisoning has been dramatically reduced. "
01/01/2001 - "The most recent and best-designed randomized controlled clinical trial, performed in Salt Lake City, supports the efficacy of HBO2 in severe acute CO poisoning in accordance with scientific rationale and clinical experience. "
08/01/2008 - "Children with CO poisoning had good outcomes in this series. "
01/01/2010 - "Although a large randomized trial is required to address the efficacy of this therapy, therapeutic application of HBO2 may be recommended in patients with DNS after CO poisoning."
07/01/2006 - "Further, it is generally believed that treatment of CO poisoning is more effective when performed as soon as possible after the exposure. "
03/01/2006 - "Therefore, to find new oximes able to sufficiently reactivate inhibited AChE (regardless of the type of OPCs) is still very important task for medicinal chemistry with the aim to improve the efficacy of antidotal treatment of the acute poisonings mentioned. "
01/01/2005 - "Current evidence is insufficient to indicate whether oximes are harmful or beneficial in the management of acute organophosphorus pesticide poisoning. "
04/20/2007 - "The experience gathered with the experimental and therapeutic approaches to human poisoning by OP pesticides may be helpful when oximes have to be selected against nerve agents."
05/18/1990 - "Imidazolium oximes are useful in the treatment of organophosphorus agent poisoning. "
03/01/2006 - "In this study, we undertook a meta-analysis by reviewing all clinical trials to evaluate the efficacy of oximes in the management of organophosphate poisoning. "
04/01/1993 - "The direct action does not correlate well with protection against soman poisoning in vivo, however, which suggests that additional non-reactivating properties of these compounds, at sites other than the neuromuscular junction, may also be important for their therapeutic effectiveness."
04/20/2007 - "On a mole basis, both the recombinant AChE and its PEGylated form provide higher levels of protection against soman poisoning than the native serum-derived HuBChE. "
10/01/1993 - "The combination of lower and medium PEG was somewhat less efficient, while the formulation consisting of mostly lower PEG exerted protective effects only in soman poisoning."
07/01/1985 - "However, they were only marginally effective in preventing the consequences of soman poisoning in mice (these data have been published elsewhere). "
07/01/1983 - "None of the compounds was effective against poisoning by soman. "
|5.||HI 6 (H16)IBA
01/01/2006 - "The article also discusses the possibility of successful therapy with HI-6 against poisoning in humans relative to doses used in non-human primates and relative to its ability to reactivate inhibited human AChE."
07/01/1995 - "The pharmacokinetics, safety, and apparent efficacy of HI-6 suggest it may be a superior oxime antidote against nerve agent poisoning."
07/29/2011 - "HI-6 has been safely used in individuals to treat OP insecticide poisoning, as well as in human volunteers, although its efficacy against OP nerve agent poisoning in humans cannot be demonstrated due to ethical considerations. "
12/01/1994 - "Efficacy of HI-6 and HLö-7 in preventing incapacitation following nerve agent poisoning."
03/01/1991 - "The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. "
10/01/1991 - "The most effective treatment of severe paraquat poisoning in man is uncertain. "
01/01/1987 - "There is a striking discrepancy between the efficacy of the kidneys, haemodialysis and haemoperfusion in removing paraquat from the body and the poor prognosis of paraquat poisoning even when the blood and urine concentrations (which are good indices of concentrations in lung and other tissues) are very low. "
01/01/1986 - "There is a striking discrepancy between: the efficacy of the kidneys, haemodialysis (HD) and Haemoperfusion (HP) in removing paraquat from the body and the poor prognosis of paraquat poisoning even when the blood and urine levels (which are good indices of concentrations in lung and other tissues) are very low. "
12/01/1997 - "It is also suggested that early haemoperfusion is effective in treating paraquat poisoning even in very severe cases due to its possible detoxicating effect in addition to toxin removal."
12/07/1974 - "Effective treatment for paraquat poisoning in rats and its relevance to treatment of paraquat poisoning in man."
09/06/2010 - "The therapeutic efficacy of applied antidotal regimens was tested as pretreatment given 15 min before tabun poisoning and/or as therapy given 1 min after tabun poisoning. "
01/01/2005 - "(2) The therapeutic efficacy of antidotal treatment of tabun-induced acute poisoning depends on the time of its administration regardless of the choice of the oxime. "
01/01/2015 - "In this study, for the first time we studied the nitrosative/oxidative stress in heart and kidney after acute Tabun (Ethyl N,N- Dimethylphosphoramidocyanidate) poisoning measuring by immunohistochemistry the expression of 3-nitrotyrosine--a marker for nitrosative-oxidative stress. "
01/01/2006 - "In this study, the influence of antidotal treatment of tabun poisoning on cognitive function, in the case of low-level tabun exposure, was studied. "
01/01/2015 - "We hypothesized that Tabun poisoning, as well as other organophosphorous treatment, cause specific organs' oxidative changes that have not previously been substantiated investigated. "
|8.||pralidoxime (Protopam Chloride)FDA Link
10/01/1998 - "High doses of pralidoxime (30 mg/kg followed by 8 mg/kg/h) did not induce serious side effects and may be effective in some OP pesticides poisoning."
07/01/1987 - "Poisindex, a widely used poisoning treatment resource, recommends dosing pralidoxime chloride as an intermittent iv infusion every 8-12 hours, whereas other authors have used continuous iv infusion with good results. "
01/01/2015 - "Is the World Health Organization-recommended dose of pralidoxime effective in the treatment of organophosphorus poisoning? "
03/01/2010 - "Pros: PAM (pralidoxime) is effective for acute poisoning of organophosphorus]."
01/01/2014 - "The efficacy of pralidoxime in organophosphorus poisoning: a commentary."
01/01/2010 - "Oral activated charcoal (oAC) is a safe and well tolerated treatment for acute poisoning, more recently shown to have significant immunomodulatory effects in man. "
05/01/2009 - "Administration of repeated doses of charcoal (1-2 g/h every 2-4 hours) may be effective in case of oleander poisoning. "
09/01/2007 - "Charcoal HP was an effective treatment for severe FAM poisoning. "
01/01/2007 - "Although activated charcoal is widely used for the treatment of self-poisoning, its effectiveness is unknown. "
12/01/2003 - "Activated charcoal is useful in the management of poisonings, but it is not harmless. "
|10.||Obidoxime Chloride (Obidoxime)IBA
01/01/1995 - "Efficacy of obidoxime in human organophosphorus poisoning: determination by neuromuscular transmission studies."
01/01/1997 - "Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning."
09/01/2009 - "The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. "
09/01/2009 - "Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships."
09/01/2009 - "The effects of obidoxime in the treatment of organophosphate poisoning were assessed by comparing the clinical course with its effects on laboratory parameters relevant to poisoning. "
11/01/2012 - "To evaluate the therapeutic efficacy of hemoperfusion in the treatment of intermediate myasthenia syndrome (IMS) following acute organophosphate poisoning (AOPP). "
11/01/2012 - "[To evaluate the therapeutic efficacy of hemoperfusion in treating intermediate syndrome following acute organophosphate poisoning]."
09/01/2007 - "The present study was conducted to investigate the efficacy of hemoperfusion (HP) on poisoning, and the pharmacokinetics of the poison during and after HP. "
11/01/2005 - "In acute organophosphate poisoning, the efficacy of hemoperfusion on clinical status and mortality."
08/01/2004 - "[The clinical efficacy of hemoperfusion in treatment of drug poisoning]."
|2.||Renal Dialysis (Hemodialysis)
01/01/2004 - "Based on volunteer and clinical studies, urine alkalinization should be considered as first line treatment for patients with moderately severe salicylate poisoning who do not meet the criteria for hemodialysis. "
01/01/2004 - "In conclusion, urine alkalinization should be considered first line treatment in patients with moderately severe salicylate poisoning who do not meet the criteria for hemodialysis. "
07/01/2014 - "The aim of the study was to describe the characteristics of toxic alcohol poisoning reported to US poison centers, the trends in the incidence of antidote use and hemodialysis treatment, as well as the related mortality. "
06/01/2015 - "Intermittent hemodialysis is the preferred ECTR modality in VPA poisoning."
06/01/2015 - "Intermittent hemodialysis is the preferred ECTR in VPA poisoning (1D). "
|3.||Intensive Care (Surgical Intensive Care)
03/01/1993 - "The charts of all cases of self-poisoning admitted to an intensive care unit over one year are reviewed Two distinct groups are seen, according to the substances ingested The group who took prescription medications tended to be younger, and had a better outcome Those poisoned with household or industrial products were older, had a longer stay in intensive care, needed more intensive therapy and organ support and had a higher mortality."
11/01/2008 - "We hope that continuing research will offer further insights into the management of such events, and we are confident that improved medical management of OP and CRB poisoning will result in a reduction of morbidity and other complications associated with intensive care procedures and hospitalization."
11/01/2012 - "This study aims to determine the clinical pattern of severe drug overdose as well as the factors influencing the duration of intensive care The clinical characteristics and course of consecutive adult patients admitted with a diagnosis of acute drug poisoning in the ICU of a tertiary hospital in Oman from January 2007 to December 2008 were reviewed retrospectively from the electronic case records. "
09/01/2010 - "This is the largest study of its kind in the Chinese population and provided information on the pattern of severe acute poisoning requiring intensive care admission and the outcomes of the patients concerned."
09/01/2015 - "We aimed to investigate intensive care management provided to OP poisoning patients in a tertiary care hospital in Turkey. "
07/01/2013 - "The cure rate of the patients with hyperbaric oxygen therapy within 6 hours after the poisoning for 100% (115/115), It was significantly higher than that of patients treated for more than 6 hours [The cure rate was 78.9% (45/57)], The difference was statistically significant (P < 0.05). "
11/01/1998 - "[Hyperbaric oxygenation as a method of intensive therapy in acute exogenous poisoning]."
02/01/1997 - "Accumulation of more than 24 inches of snow contributed to the poisoning of 25 patients who were subsequently treated with hyperbaric oxygen therapy. "
10/10/1993 - "[Hyperbaric oxygen therapy in the management of poisoning]."
03/01/1989 - "For moderate to severe poisoning, hyperbaric oxygen therapy is the treatment of choice. "
01/01/2009 - "As the existence of ionic liquid moiety, BMIm(+), accelerated the electron transfer at the electrode surface, the poisoning effect of long chain C(12)H(25)SO(-) (4) on the electrode surface was eliminated and reproducible ECL intensities with relative standard derivation of 1.02% (n=6) were obtained. "
08/01/2005 - "The modification of the electrode improved the electrophoretic analysis performance by lowering the detection potential and enhancing the signal-to-noise characteristic without surface poisoning of the electrode. "
05/28/2014 - "However, at 500 to 600 °C, a temperature range rarely examined for sulphur poisoning, but of great interest for next generation SOFCs, we report that H2S-exposed Ni-YSZ anodes are catalytic towards the H2 oxidation reaction, rather than poisoned. "
01/21/2013 - "Linear responses were obtained with a detection limit of 50 nM. More importantly, the proposed electrode also had good stability, high resistance against poisoning by chloride ion and commonly interfering species. "
01/01/2013 - "While significant progress has been made in anode materials with enhanced tolerance to coking and contaminant poisoning, cathodic polarization still contributes considerably to energy loss, more so at lower operating temperatures. "