Pneumonectomy (Lung Volume Reduction)

The excision of lung tissue including partial or total lung lobectomy.

Also Known As:

Lung Volume Reduction; Partial Pneumonectomy; Partial Pneumonectomies; Pneumonectomies; Pneumonectomy, Partial; Reduction, Lung Volume; Volume Reduction, Lung; Bronchoscopic Lung Volume Reduction; Endoscopic Lung Volume Reduction; Lung Volume Reduction Surgery

Networked: 5848 relevant articles (300 outcomes, 422 trials/studies)

Relationship Network

Therapy Context: Research Results

Operative Surgical Procedures: 34913
- Pneumonectomy: 5848
- Thoracic Surgical Procedures: 98
  - Pulmonary Surgical Procedures: 9
    - Pneumonectomy: 5848

Experts

1.	Slebos, Dirk-Jan: 63 articles (01/2022 - 09/2012)
2.	Herth, Felix J F: 49 articles (01/2022 - 07/2007)
3.	Criner, Gerard J: 45 articles (05/2021 - 01/2002)
4.	Weder, Walter: 42 articles (05/2021 - 04/2002)
5.	Klooster, Karin: 37 articles (01/2022 - 09/2012)
6.	Shah, Pallav L: 37 articles (01/2022 - 06/2012)
7.	Spaggiari, Lorenzo: 36 articles (08/2022 - 04/2003)
8.	Opitz, Isabelle: 27 articles (12/2021 - 10/2005)
9.	Sugarbaker, David J: 25 articles (12/2019 - 12/2002)
10.	Hartman, Jorine E: 23 articles (01/2022 - 11/2012)

Related Diseases

1.	Emphysema 01/01/2012 - "Surgical approaches include lung transplantation and lung volume reduction and the latter has been shown to improve exercise tolerance, quality of life, and survival in highly selected patients with advanced emphysema. " 07/01/2011 - "For lung volume reduction surgery, there have been new insights into the counterintuitive observation that lung function in severe emphysema can be improved by resecting the most diseased portions of the lungs. " 10/01/2003 - "Lung volume reduction surgery (LVRS) has been shown to improve lung function, exercise performance, and quality of life in highly selected individuals with severe emphysema; however, major questions regarding the efficacy and long-term outcomes of LVRS still remain unanswered. " 01/01/2002 - "To investigate which of three types of CT imaging yielded the best results in estimating the degree of emphysema in patients undergoing evaluation for lung volume reduction surgery (LVRS), whether there was any difference in this regard between the cranial and caudal part of the lung, and whether the degree of emphysema had an impact on the estimation. " 08/01/1998 - "Lung volume reduction operation shows promise in relieving symptoms and improving function in highly selected patients with emphysema. "
2.	Chronic Obstructive Pulmonary Disease (COPD) 06/03/2006 - "Together with optimal pharmacotherapy, COPD can be effectively treated by rehabilitation, lung volume reduction surgery and lung transplantation. " 01/01/2001 - "Marked improvement of neuropsychological impairment in a patient with chronic obstructive pulmonary disease after lung volume reduction surgery." 11/27/2020 - "Lung volume reduction therapies are beneficial in appropriately selected patients with COPD, but few procedures are performed, and treatment pathways are unclear. " 01/01/2017 - "Lung volume reduction surgery (LVRS) has been shown to be beneficial in patients with chronic obstructive pulmonary disease, but there is low uptake, partly due to perceived concerns of high operative mortality. " 10/01/1996 - "Lung volume reduction surgery in select, ventilator-dependent COPD patients can result in improved gas exchange and respiratory mechanics that enable successful weaning and overall improved functional status."
3.	Dyspnea (Shortness of Breath) 01/01/1997 - "Further adjuvant therapy (at least 6 months after completion) in 11 patients and the type of pneumonectomy (right-side: n = 11, left-side: n = 25) did not result in additional significant reduction of lung function and of single quality of life dimensions, except that "Dyspnea" in patients with right-sided pneumonectomy (66.7) was significantly more frequent than in patients with left-sided pneumonectomy (44.0). " 03/01/2010 - "Currently available data on efficacy of bronchoscopic lung volume reduction are not consistently conclusive, and subjective benefit in dyspnea scores is a more frequent finding than improvements on spirometry or exercise tolerance. " 08/01/1996 - "Lung volume reduction is a surgical procedure that is effective in relieving the dyspnea and improving the patient's quality of life." 01/01/2010 - "The currently available data on efficacy of bronchoscopic lung volume reduction are not conclusive, although subjective benefit in dyspnea scores and quality of life is a frequent finding. " 08/01/2009 - "The improvement in exercise capacity and dyspnea following lung volume reduction surgery is associated with a substantial reduction in neural drive to the inspiratory muscles."
4.	Lung Neoplasms (Lung Cancer) 09/01/2010 - "Sleeve resection proved to be good therapy for lung cancer and has a lower morbidity and mortality than standard pneumonectomies and results in better lung function and quality of life. " 12/01/2007 - "We carried out two cases of completion tracheal sleeve pneumonectomy for suture line recurrence of lung cancer after bronchial sleeve lobectomy of the right upper lobe and achieved good results, which suggests that completion tracheal sleeve pneumonectomy for suture line recurrence after bronchial sleeve lobectomy is a good treatment modality for selected patients." 04/01/1992 - "We performed pneumonectomy for lung cancer detected in a patient on chronic hemodialysis for 4 years and obtained good results." 01/01/2023 - "Development and validation of web-based dynamic nomograms predictive of disease-free and overall survival in patients who underwent pneumonectomy for primary lung cancer." 10/31/1979 - "The authors conclude that in selected lung cancer patients lobectomy with bronchoplastic procedures is superior to pneumonectomy for tissue sparing advantages."
5.	Neoplasms (Cancer) 01/01/2010 - "They yield the best results if applied in tumors measuring less than 2 cm. Stage II, characterized by involvement of the N1-position and/or a more central tumor growth, has a 5-year survival of 45-52% and requires treatment by lobectomy or pneumonectomy. " 12/01/2005 - "Locoregional tumor recurrence can be dramatically reduced with combinations of extrapleural pneumonectomy and radiation therapy. " 09/01/2015 - "The patient had a significant reduction in tumor size, allowing for complete resection by pneumonectomy. " 07/01/1992 - "A significant reduction of tumor infiltration was achieved allowing a radical pneumonectomy instead of a sleeve pneumonectomy with resection of the main carina. " 06/01/1991 - "In univariate analysis, baseline characteristics significantly influencing survival and disease-free interval (DFI) were the tumor stage (T1 and T2 versus T3), tumor histology (oat and intermediate versus combined cell type), and type of resection (lobectomy versus pneumonectomy). "

Related Drugs and Biologics

1.	Monocrotaline
2.	salicylhydroxamic acid (SHAM)
3.	magnolol
4.	Angiotensin II
5.	Endothelin-1 (Endothelin 1)
6.	Cisplatin (Platino)
7.	Pemetrexed (MTA)
8.	Oxygen (Dioxygen)
9.	Anticoagulants
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Pneumonectomy (Lung Volume Reduction)
3.	Radiotherapy
4.	Lung Transplantation
5.	Drug Therapy (Chemotherapy)