Pleural Effusion (Pleural Effusions)

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3415 relevant articles (145 outcomes, 244 trials/studies) found for this Disease

Description: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.

Also Known As:

Pleural Effusions; Effusion, Pleural; Effusions, Pleural

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 373

Pleural Diseases: 244

Pleural Effusion: 3415

Malignant Pleural Effusion: 698

Related Diseases

1.	Ascites
2.	Neoplasms (Cancer)
3.	Carcinoma (Carcinomatosis)
4.	Pneumonia (Pneumonitis)
5.	Pneumothorax

Experts

1.	Light, Richard W: 8 articles (02/2007 - 07/2002)
2.	Light, R W: 8 articles (08/2006 - 09/2000)
3.	Sahn, Steven A: 4 articles (05/2007 - 03/2002)
4.	Kalomenidis, Ioannis: 4 articles (02/2007 - 07/2003)
5.	Lee, Y C: 4 articles (02/2004 - 12/2000)
6.	Siafakas, Nikolaos M: 3 articles (05/2008 - 03/2002)
7.	Dikensoy, Oner: 3 articles (05/2008 - 01/2005)
8.	Barnette, Randal: 3 articles (02/2007 - 07/2003)
9.	Alegre, J: 3 articles (01/2005 - 01/2000)
10.	Rogers, J T: 3 articles (08/2001 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pleural Effusion:

1.	Talc FDA Link 07/01/1995 - "Recent study results indicate that intrapleural instillation of iodized talc is an adequate and effective treatment for control of neoplastic or benign pleural effusion." 06/01/1995 - "The intrapleural insufflation of talc was effective in preventing recurrence of pleural effusion" 05/01/1992 - "These observations indicate that intrapleural instillation of a slurry of iodized talc is a safe, adequate, and effective treatment for control of neoplastic or benign pleural effusions." 12/01/1994 - "The objective of this study is to present our experience with a low dose of aerosolized talc for controlling nonmalignant pleural effusions" 10/01/2003 - "These inhibitory effects of talc on MMP-1 and inflammatory mediators associated with the reduction of pleural effusion could constitute an effective means to evaluate the evolution of the treatment." Order ALL the reference details at left...
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 09/03/1996 - "Corticosteroids led to rapid improvement with complete resolution of the pleural effusion." 09/01/1993 - "There was a good clinical and roentgenographic response and the pleural effusion responded well to corticosteroids" 09/01/2006 - "The use of corticosteroids may be helpful in case of repeated, uncontaminated pleural effusions" 05/01/1998 - "Further studies are needed to determine whether high-dose corticosteroids are also effective on the resolution of pleural effusions associated with other malignant disease." 09/16/1965 - "Role of intrapleural corticosteroids in tuberculous pleural effusion: a clinicotherapeutic trial of 50 cases." Order ALL the reference details at left...
3.	Urinary Plasminogen Activator (Urokinase)FDA LinkGeneric 09/01/1996 - "CONCLUSION: Urokinase instillation through a percutaneous catheter was effective in the treatment of loculated pleural effusion in most patients but was not effective in patients whose pleural fluid had a honeycomb appearance on sonography or whose parietal pleura had a thickness of more than 5 mm on CT scans." 12/01/1996 - "To assess our experience, the role and efficacy of administering intercavitary urokinase (UK) through a small caliber catheter (SCC) implanted with ultrasound guidance as part of the treatment for pleural effusions (PE) that are multiloculated and/or loculated" 11/01/2006 - "CONCLUSION: Our study shows that patients with loculated tuberculous pleural effusion treated with urokinase suffered less from residual pleural thickening, as measured after six months, than those treated by simple drainage" 11/01/2006 - "A study of loculated tuberculous pleural effusions treated with intrapleural urokinase." 05/01/2005 - "The aim of the present study was to evaluate the utility of urokinase in the treatment of infectious pleural effusions in children" Order ALL the reference details at left...
4.	Mitoxantrone (Novantrone)FDA LinkGeneric 06/01/1994 - "Mitoxantrone has recently been tested to treat effusions, and preliminary results suggest the high efficacy of this drug in the treatment of peritoneal, pericardial and pleural effusions" 02/01/1993 - "Mitoxantrone has been tested recently in the treatment of effusions, and preliminary results suggest high efficacy of this drug in the treatment of peritoneal, pericardial, and pleural effusions" 04/01/1997 - "Intrapleurally instilled mitoxantrone in metastatic pleural effusions: a phase II study." 07/01/1993 - "Mitoxantrone in pleural effusions." 05/01/1998 - "Because of the rising importance of talcum pleurodesis in the therapeutic management of malignant and benign pleural effusions in Germany, pleural samples after talcum pleurodesis were compared to microscopic, immunohistochemical, and scanning electron microscopy findings after Tetracyclin and Novantron pleurodesis in 24 patients up to 18 months after intrapleural therapy" Order ALL the reference details at left...
5.	Prednisolone (Predate)FDA LinkGeneric 11/01/1998 - "Treatment with an increased dose of prednisolone achieved a rapid remission of the pleural effusion" 09/01/2007 - "Prednisolone administered to reduce the pleural effusion." 12/01/2003 - "During the course of reducing the prednisolone dose by up to 5 mg per day, pleural effusion appeared in the right lung" 12/01/2001 - "A diagnosis of ABPA associated with bilateral pleural effusions was made and the patient was commenced on prednisolone" 11/01/2001 - "After prednisolone was administered, the peripheral blood eosinophil count normalized rapidly, and subsequently, the pleural effusion and infiltration shadows in the lung disappeared." Order ALL the reference details at left...
6.	Cyclophosphamide (Cytoxan)FDA Link 07/01/1996 - "Massive pleural effusion attributed to high-dose cyclophosphamide during conditioning for BMT." 01/01/1982 - "Effective levels of cyclophosphamide and metabolites in pleural effusions during intravenous therapy (author's transl)]" 01/01/1978 - "Treatment with cyclophosphamide was followed by clinical improvement and the disappearance of the pleural effusion." 12/01/1998 - "Hypoalbuminemia and low serum levels of complements improved remarkably and the pleural effusion and ascites disappeared after cyclophosphamide pulse therapy four times monthly" 07/01/1996 - "A 37-year-old male developed massive pleural effusion leading to respiratory failure and electromechanical dissociation within 24 h after the second dose of 4200 mg cyclophosphamide (CY) during conditioning for allogeneic bone marrow transplantation for chronic myelogenous leukemia" Order ALL the reference details at left...
7.	Doxycycline (Vibramycin)FDA LinkGeneric 03/01/1996 - "In this limited number of patients, doxycycline 1 g appeared to be safe and effective for the treatment of pleural effusions and pneumothoraces" 07/01/2007 - "STUDY OBJECTIVE: To determine the effectiveness of intrapleural doxycycline for the treatment of postcardiotomy pleural effusions in pediatric patients" 07/01/2007 - "Dosage and effectiveness of intrapleural doxycycline for pediatric postcardiotomy pleural effusions." 08/01/2006 - "Doxycycline is an antibiotic agent, which was used in the treatment of pneumothoraces and pleural effusions" 02/01/2006 - "Four episodes of recurrent pleural effusions were also controlled with per os doxycycline" Order ALL the reference details at left...
8.	Anti-Bacterial Agents (Antibiotics)IBA 06/01/2005 - "Purulent pericardial and bilateral pleural effusion was diagnosed, and the patient was treated with antibiotics, repeated pleurocentesis and pericardial drainage with daily polihexanide lavage" 11/04/2004 - "Parapneumonic pleural effusion is a possible complication and has to be treated surgically when the patient does not respond to antibiotics" 10/01/1997 - "METHODS: A series of seven consecutive children who had loculated pleural effusion that did not respond to drainage and antibiotics is reported" 05/01/1996 - "The only noteworthy complication was 1 case of infectious pleural effusion of unknown etiology which was treated by evacuation and antibiotics" 06/21/2007 - "A thoracostomy tube was inserted to drain the pleural effusion, and the patient's previous antibiotics reinstated" Order ALL the reference details at left...
9.	Adenosine DeaminaseIBA 10/01/1990 - "Efficacy of adenosine deaminase in the diagnosis of pleural effusions." 04/01/2007 - "The aim of this study was to evaluate the value of adenosine deaminase (ADA) concentration in the pleural effusions for differentiating exudates from transudates" 12/01/2005 - "OBJECTIVE: The purpose of this study was to evaluate the usefulness of a new parameter, pleural adenosine deaminase (PADA), for separating transudative pleural effusion from exudative pleural effusion, and to compare the results with other tests (albumin gradient and protein gradient)" 12/01/2004 - "STUDY OBJECTIVE: Measurement of pleural fluid adenosine deaminase (ADA) levels is useful in the differential diagnosis of pleural effusions" 01/01/1989 - "In this paper we present the results of a study about the diagnostic utility of Adenosine Deaminase (ADA) determination for diagnosing the tuberculous pleural effusion" Order ALL the reference details at left...
10.	Carcinoembryonic AntigenIBA 04/01/2002 - "BACKGROUND: The determination of the pleural fluid (PF) carcinoembryonic antigen (CEA) concentration has proved helpful in the differentiation between pleural effusions (PE) of malignant and benign origin" 04/01/1998 - "False-positive results of carcinoembryonic antigen in pleural effusions." 11/01/1995 - "The aim of the study was to determine the diagnostic value of carcinoembryonic antigen (CEA) and ferritine in malignant and tuberculous non-bloody pleural effusion" 06/04/1988 - "Comparison of the initial yield in cytology, biopsy and carcinoembryonic antigen in the study of pleural effusions]" 05/01/1998 - "Usefulness of carcinoembryonic antigen in pleural effusion diagnosis." Order ALL the reference details at left...

Therapies and Procedures

1.	Pleurodesis 04/01/2002 - "Accordingly, pleurodesis with minocyclin was undertaken, which was fortunately effective for controlling the pleural effusion." 03/01/2007 - "OBJECTIVE: To assess whether intractable pleural effusions in pediatric oncology patients at end of life could be sufficiently relieved by pleurodesis" 11/01/2006 - "Overall, this review supports the safety and efficacy of iodopovidone as an agent for chemical pleurodesis in cases of recurrent pleural effusions and pneumothoraces regardless of their etiology." 11/01/2004 - "STUDY OBJECTIVES: Patients with recurrent pleural effusions secondary to malignancy are subjected to pleurodesis if clinically indicated" 03/01/2004 - "STUDY OBJECTIVES: Pleurodesis is generally regarded to give the best palliation in recurrent pleural effusion" Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 10/01/2007 - "OBJECTIVE: To evaluate the clinical efficacy of Xiaoshui Powder as auxiliary with chemotherapy for treatment of tuberculous remnant pleural effusion" 02/01/1996 - "The patient achieved remission with chemotherapy, but she later relapsed, with right pleural effusion, and died" 02/01/2006 - "CONCLUSIONS: In this patient group, presenting with stable symptoms after control of pleural effusion, the early use of chemotherapy provided an extended period of symptom control, and in this small trial a trend to survival advantage." 07/01/2005 - "Important national trials are ongoing: in the UK the addressed questions were the role of radical surgery (MARS Trial), the role of chemotherapy (MS-01 trial) and the role of VATS on active treatment of pleural effusion" 04/01/1996 - "Study of paradoxical response to chemotherapy in tuberculous pleural effusion." Order ALL the reference details at left...
3.	Chest Tubes (Chest Tube) 10/01/1988 - "The examination contributed valuable information that aided in planning and evaluating therapy: (1) it assessed mediastinal and pleural cavity involvement prior to surgery or drainage; (2) it evaluated the efficacy of drainage; (3) it gave excellent information about the position of chest tubes; and (4) it demonstrated unsuspected pneumothoraces, pleural effusion, pulmonary infiltrates, and lung perforation by a chest tube" 04/01/1998 - "This study suggested that the curved chest tube would be safe and useful in completing drainage of pleural effusion." 09/01/2008 - "Pleural effusion characteristics seem to have an influence on the need for fibrinolytic and the length of chest tube treatment." 09/18/2006 - "The chest tube was removed when the pleural effusion volume decreased to 200 ml or less per day" 09/01/2006 - "Median duration of chest tube insertion was 6.8 days, and mean volume of pleural effusion was 1,015.0 mL at 3 days total postoperatively" Order ALL the reference details at left...
4.	Thoracostomy 10/01/1994 - "Tube thoracostomy is a safe and effective treatment for massive pleural effusion and lung collapse in the case of OHSS." 01/01/2006 - "This study aims to evaluate the efficacy of the Bonanno catheter compared with closed-tube thoracostomy in draining pleural effusion in 38 patients following routine cardiac surgery between 2003 and 2004" 04/01/1997 - "STUDY OBJECTIVES: To evaluate the clinical safety, efficacy, and cost of a small indwelling pleural catheter (7F, Turkel Safety Thoracentesis System [Sherwood, Davis, and Geck; St. Louis]) vs repeated needle thoracentesis or closed tube thoracostomy as a means to drain a large-volume pleural effusion" 09/01/2007 - "Therapeutic thoracentesis may be preferable over tube thoracostomy in select clinical scenarios in which a symptomatic pleural effusion develops after an isolated and limited physiologic insult" 07/01/2002 - "INTERVENTIONS: Intravenous hydration, inotropic support, thoracostomy tube drainage of a pleural effusion, and prolonged antimicrobial therapy" Order ALL the reference details at left...
5.	Aftercare (After-Treatment) 03/01/2006 - "Pleural effusions developed after treatment in six patients (25%), which proved to be malignant in one patient" 01/01/1995 - "The pleural effusion disappeared after treatment with antituberculous drugs" 03/01/1990 - "April); the period of hospitalisation (I: 4.07 months, S: 5.80 months, T: 4.77 months); the positive rate of tubercle bacilli in the pleural effusion (I: 9.0%, S: 12.9%, T: 10.5%); %VC (mean value) on admission (I: 71.4%, S: 69.8%, T: 70.7 +/- 17.0%); %VC after treatment (I: 79.0%, S: 79.7%, T: 79.4 +/- 17.9%), and we found no significant difference in the above factors between I. and S" 06/01/2004 - "Pleural effusion as a manifestation of ovarian hyperstimulation syndrome, after treatment with triptoreline for uterus myomata]" 12/01/1997 - "After treatment, numerous adhesions were present in 15 cases; Pleural effusion reduced in 7 patients, and no effect was noted in 4 patients" Order ALL the reference details at left...

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