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Tissue Plasminogen Activator (Alteplase)

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Also Known As:
Alteplase; Activase; T-Plasminogen Activator; Actilyse; Boehringer Ingelheim Brand of Alteplase; Genentech Brand of Alteplase; Hoffmann-La Roche Brand of Alteplase; Lysatec rt-PA; Promeco Brand of Alteplase; TTPA; Tisokinase; Tissue Activator D-44; Alteplase Genentech Brand; Alteplase Promeco Brand; Hoffmann La Roche Brand of Alteplase; Lysatec rt PA; Lysatec rtPA; Plasminogen Activator, Tissue; Plasminogen Activator, Tissue Type; T Plasminogen Activator; Tissue Activator D 44; Tissue Type Plasminogen Activator; Plasminogen Activator, Tissue-Type; Tissue-Type Plasminogen Activator
Networked: 6817 relevant articles (584 outcomes, 1223 trials/studies)

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Drug Context: Research Results

Experts

1. Grotta, James C: 50 articles (07/2015 - 04/2002)
2. Alexandrov, Andrei V: 49 articles (12/2015 - 01/2002)
3. Hill, Michael D: 47 articles (12/2015 - 01/2002)
4. Montaner, Joan: 43 articles (02/2015 - 06/2002)
5. Demchuk, Andrew M: 42 articles (12/2015 - 01/2002)
6. Kimura, Kazumi: 41 articles (01/2015 - 01/2004)
7. Molina, Carlos A: 39 articles (12/2015 - 06/2002)
8. Davis, Stephen M: 38 articles (08/2015 - 04/2003)
9. Schwamm, Lee H: 37 articles (12/2015 - 11/2004)
10. Broderick, Joseph P: 35 articles (12/2015 - 02/2004)

Related Diseases

1. Stroke (Strokes)
2. Myocardial Infarction
3. Thrombosis (Thrombus)
4. Hemorrhage
5. Pulmonary Embolism

Related Drugs and Biologics

1. Tissue Plasminogen Activator (Alteplase)
2. Urokinase-Type Plasminogen Activator (Urokinase)
3. Streptokinase
4. Heparin (Liquaemin)
5. Plasminogen Activators (Plasminogen Activator)
6. tenecteplase
7. Fibrin
8. Aspirin (Acetylsalicylic Acid)
9. Plasminogen Activator Inhibitor 1
10. 4- Acetamido- 4'- isothiocyanatostilbene- 2,2'- disulfonic Acid (SITS)

Related Therapies and Procedures

1. Thrombolytic Therapy
2. Catheters
3. Injections
4. Vitrectomy
5. Angioplasty (Angioplasty, Transluminal)