|4.||Pituitary Neoplasms (Pituitary Adenoma)
|1.||Kovacs, Kalman: 64 articles (09/2015 - 02/2002)|
|2.||Scheithauer, Bernd W: 44 articles (11/2012 - 02/2002)|
|3.||Yamada, Shozo: 40 articles (01/2015 - 01/2002)|
|4.||Melmed, Shlomo: 40 articles (06/2014 - 01/2002)|
|5.||Horvath, Eva: 38 articles (04/2015 - 02/2002)|
|6.||Korbonits, Márta: 35 articles (02/2016 - 01/2002)|
|7.||Lloyd, Ricardo V: 34 articles (09/2011 - 01/2002)|
|8.||Teramoto, Akira: 30 articles (01/2015 - 10/2002)|
|9.||Colao, Annamaria: 29 articles (12/2015 - 06/2002)|
|10.||Rotondo, Fabio: 28 articles (09/2015 - 11/2002)|
12/01/2005 - "The development of animal models for pituitary tumors and hormone hypersecretion has proven to be critical for the implementation of novel treatment strategies and gene therapy approaches. "
06/01/1997 - "Following transsphenoidal removal of the pituitary tumor and appropriate hormone replacement, complete remission of the skin disorder was obtained. "
02/15/1997 - "SRIF analogs with selective affinity for this receptor may therefore be more effective in the treatment of hormone-secreting pituitary adenomas."
08/23/2011 - "To investigate the effect of incretion hormones on growth pituitary adenoma ectomy patients and evaluate its long-term therapeutic efficacy. "
08/23/2011 - "[Effects of incretion hormones on growth pituitary adenoma ectomy and evaluation of long-term therapeutic efficacy]."
|2.||Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
08/01/2006 - "Somatostatin (SST) analogues play an important role in the medical management of somatotroph pituitary adenomas and new agonists have the potential to be effective in a wider group of pituitary and other tumours. "
04/01/2003 - "This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease."
01/01/1993 - "In patients with visual disturbances related to chiasmal compression by nonfunctioning pituitary tumors, somatostatin analog administration has been reported to result in rapid improvement in visual acuity. "
04/01/2000 - "Somatostatin analogs have been shown to be effective for the treatment of TSH-secreting pituitary adenomas. "
08/01/2006 - "These cases illustrate that long-term treatment with somatostatin analogs offers an alternative choice in selected acromegalic patients, such as those with pituitary tumor who cannot be cured by surgery, those who have unacceptable anesthetic risk and those who refuse surgery."
|3.||Octreotide (Sandostatin)FDA LinkGeneric
01/01/2007 - "DCE-MRI in acromegalic tumours treated with octreotide showed a significant reduction in functional vascularity after octreotide therapy compared to baseline in pituitary adenomas. "
11/01/1988 - "Thus, preoperative administration of SMS 201-995 consistently induced shrinkage of GH-producing pituitary tumors, and the apparent remission rate was high in the treated patients."
12/01/2005 - "Octreotide LAR could be used as primary therapy in patients harbouring large pituitary tumors, who are less likely to be cured by neurosurgery."
08/01/2012 - "This study aimed to report the efficacy and safety of the long-acting octreotide formulation in patients with TSH-secreting pituitary adenomas after incomplete surgery and octreotide treatment failure. "
04/17/1995 - "In this study, the apoptotic effect of the octreotide SS analog, SMS 201-995, was investigated in phase synchronized AtT-20 mouse pituitary tumor cells. "
|4.||Growth Hormone (Somatotropin)IBA
09/01/2014 - "Cavernous sinus (CS) invasion is the most important preoperative predictor of remission in the surgical treatment of growth hormone-producing pituitary adenomas. "
09/01/2001 - "Although it seems to be very effective in controlling growth and secretion of the growth hormone-secreting pituitary adenomas, there is a chance that some major risks from gamma knife radiosurgery might occur. "
01/01/2013 - "Transphenoidal surgery is an effective treatment for acromegalic patients with growth hormone (GH) producing pituitary adenomas. "
01/01/2015 - "Cavernous sinus invasion and effect of immunohistochemical features on remission in growth hormone secreting pituitary adenomas."
12/01/2013 - "Endoscopic endonasal approach for growth hormone secreting pituitary adenomas: outcomes in 53 patients using 2010 consensus criteria for remission."
|5.||Bromocriptine (Parlodel)FDA LinkGeneric
12/01/1986 - "Rapid improvement in visual field defects following bromocriptine treatment of patients with non-functioning pituitary adenomas."
03/01/1982 - "Bromocriptine causes a clinically significant reduction in size of nonsecreting as well as secreting pituitary tumors with the same success rate as that of conventional treatments.U"
04/01/2002 - "Although medical treatment with bromocriptine is effective for patients with pituitary adenomas, little is known about the molecular mechanisms of gene regulation mediated by D2 receptors. "
02/01/1989 - "Although it is well known that bromocriptine (BC) is effective in the treatment of functioning pituitary adenoma, this agent sometimes causes severe gastrointestinal side effects. "
04/01/1981 - "2.5 mg per day of bromocriptine has been effective in 2 patients without a pituitary adenoma and ineffective in the other 4 patients with a pituitary adenoma. "
|6.||temozolomide (Temodar)FDA LinkGeneric
01/01/2012 - "The alkylating reagent temozolomide (TMZ) was recently shown to be effective as a treatment for pituitary carcinoma. "
09/01/2010 - "The observed lack of or low-level expression of MGMT by this distinctive, clinically aggressive form of pituitary adenoma suggests potential efficacy of treatment with the alkylating agent temozolomide."
10/01/2006 - "These two examples demonstrate that temozolomide may be effective in treating pituitary carcinomas and thus should be considered in the treatment algorithm for these difficult cases."
06/01/2006 - "Temozolomide: a novel treatment for pituitary carcinoma."
12/01/2010 - "We assessed the efficacy of treatment with temozolomide, an oral second-generation alkylating agent, in a consecutive series of six patients with aggressive pituitary adenomas. "
|7.||Dopamine Agonists (Dopamine Agonist)IBA
10/01/2013 - "We reassure that the dopamine agonist is safe and effective for the treatment of invasive pituitary adenomas. "
12/01/2014 - "Two large pituitary tumors disappeared on MRI following long-term dopamine agonist therapy. "
01/01/2014 - "Four of 9 border zone patients with non-functioning pituitary adenoma were initially treated with dopamine agonists. "
10/01/2012 - "Aggressive surgical treatment, radiation, dopamine agonists, antiangiogenic drugs, and other chemotherapeutics all have roles in the treatment of aggressive pituitary tumors. "
01/01/2006 - "Can dopamine agonists prevent postoperative remnant enlargement in nonfunctioning pituitary adenomas?"
|8.||Adrenocorticotropic Hormone (ACTH)FDA Link
02/01/2001 - "The ACTH level also persisted high until 300 min after complete pituitary tumor resection in one cured patient with Nelson's syndrome. "
02/01/2001 - "In all 14 Cushing's disease patients (cured and not cured), mean plasma ACTH levels were significantly greater 10 min after pituitary tumor resection (54.4+/-12.8 pmol/l) than in the premanipulation period (ACTH=26.3+/-5.3 pmol/l) (p=0.005). "
04/01/2003 - "Spoiled gradient recalled acquisition in the steady state technique is superior to conventional postcontrast spin echo technique for magnetic resonance imaging detection of adrenocorticotropin-secreting pituitary tumors."
08/01/2001 - "Stereotactic radiosurgery is a safe and effective method in the treatment of patients with adrenocorticotropic hormone-producing pituitary tumors, and the effect of treatment is long-lasting. "
07/01/2002 - "Pituitary tumor stained for adrenocorticotropic hormone was detected in 78% of resected pituitary tissue specimens obtained from patients who achieved remission, compared with 53% from patients who experienced surgical failure (P = 0.06). "
|9.||Thyrotropin (Thyroid-Stimulating Hormone)FDA Link
11/01/1990 - "Thyrotropin-secreting pituitary adenomas have been diagnosed more frequently as radiographic techniques and biochemical assays have improved; however, they remain uncommon and are unfamiliar to most neurosurgeons. "
08/01/2015 - "The first-choice treatment of thyrotropin (TSH)-secreting pituitary adenomas is surgical adenomectomy, with 40-60% of patients cured after surgery. "
12/01/2014 - "The aim of this study was to analyze clinicopathological characteristics and treatment outcomes in a large single-center clinical series of cases of thyrotropin (TSH)-secreting pituitary adenomas. "
12/01/2014 - "Clinicopathological characteristics and therapeutic outcomes in thyrotropin-secreting pituitary adenomas: a single-center study of 90 cases."
01/01/2014 - "A total of 20 patients with thyrotropin-secreting pituitary adenomas hospitalized in Shanghai Huashan Hospital from 2006 to 2013 were enrolled in the study. "
10/01/2013 - "When a pituitary tumor is not convincingly identified, inferior petrosal sinus sampling remains the gold standard for diagnosis, and recently, new approaches (simultaneous prolactin measurement) could improve its sensitivity and specificity. "
06/01/1978 - "In spite of improved diagnosis and treatment, the natural history of prolactin-secreting pituitary tumors and the long-range effects are still not fully appreciated. "
11/01/2011 - "In vitro studies with pituitary adenoma cells from acromegalic patients have demonstrated that the chimeric molecules have exceptional activity with regard to suppression of GH and prolactin secretion. "
03/01/2006 - "In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for GH (n=3. 7.8%). "
12/01/1996 - "In this study, the effects of CsA on prolactin (PRL) synthesis and release were investigated in GH3 cells, a clonal strain of rat pituitary tumor. "
05/01/2007 - "Radiotherapy after pituitary surgery is highly effective in reducing hormonal hypersecretion and preventing recurrences of pituitary adenomas. "
05/01/2013 - "However, this risk is small and should not preclude the use of radiotherapy as an effective treatment for uncontrolled pituitary tumors. "
11/01/2005 - "Is fractionated stereotactic radiotherapy effective in pituitary adenomas?"
10/01/1999 - "Patients with pituitary adenomas are effectively treated with a combination of surgery, radiotherapy, and medical therapy. "
12/01/1993 - "Both radiotherapy alone and post-operative radiotherapy are effective in long-term control of pituitary adenomas, and produce acceptably low complication rates."
12/01/1992 - "Of the 214 OSA patients who accepted CPAP, 181 are still on treatment, with a mean daily rate of use of 5.6 +/- 0.1 hours (mean +/- SEM); 22 patients stopped CPAP after a variable period of time; 10 patients died and one acromegalic patient was considered cured after hypophysectomy for a pituitary adenoma. "
08/01/1987 - "Only 7 of the 100 patients had no pituitary adenoma found at operation, and they obtained no clinical remission even after partial or subtotal hypophysectomy. "
12/01/2011 - "Forty-seven patients with pituitary adenoma underwent trans-sphenoidal hypophysectomy of which 25 patients with complete medical and radiological data were included in the study. "
06/01/2015 - "CS patients were defined with ≥2 claims of CS diagnosis, while CD patients were defined with CS plus a benign pituitary adenoma diagnosis or hypophysectomy in the same calendar year. "
06/01/2015 - "He had the merit to develop and popularize in Italy this approach for pituitary tumors, performing 47 transsphenoidal hypophysectomies out of his personal series of 66 patients between 1927 and 1935. "
01/01/2010 - "Transsphenoidal approach is safe and effective procedure even in large or giant pituitary adenomas, because it allows rapid and appropriate decompression of the optic nerves and chiasm with low morbidity rates. "
05/01/2013 - "Our study aimed to provide a new method to locate the optic canal and analyze the relationship between optic canal and other structures in the sella region, which can be a guidance for endoscopic sinus surgery such as the optic nerve decompression and transsphenoidal approach to the pituitary adenoma and reduced complications caused by the injury of optic nerve. "
05/01/2014 - "Signs of haemorrhage in pituitary adenomas do not necessitate immediate tumour decompression surgery, if there are no symptoms of acute haemorrhage."
12/01/2010 - "The authors confirmed adequate decompression of suprasellar space using this technique of fluoroscopy with the present intrathecal air for 10 of 12 patients with giant, non-functioning pituitary tumors. "
07/01/2009 - "This is the first report of the simultaneous combined use of trans-sphenoidal and trans-ventricular-endoscopic route for decompression of a giant pituitary adenoma. "
|4.||Drug Therapy (Chemotherapy)
12/01/1998 - "Until another more specific form of treatment is available, chemotherapy may still be of some value in patients with highly aggressive and malignant pituitary tumors, at least in achieving a temporary remission or delay in progression. "
09/01/2012 - "Pituitary carcinoma occurs in ~0.2% of resected pituitary tumours and carries a poor prognosis (mean survival <4 years), with standard chemotherapy regimens showing limited efficacy. "
10/01/2006 - "The authors report rare examples of a persistent response to cytotoxic chemotherapy in two patients with pituitary carcinoma. "
04/01/2005 - "[Capacities of chemotherapy for pituitary tumors]."
12/01/1998 - "The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors."
04/01/2002 - "Our surgical method for pituitary tumors provides good results with minimal invasion, by exploiting the advantages of a microscope and an endoscope."
07/01/2013 - "One hundred patients with pituitary adenomas who underwent endonasal endoscope-assisted TSS with EOM monitoring were included in the present study. "
03/01/2013 - "Consecutive patients who underwent endoscope-assisted microsurgical removal of pituitary adenoma were included in this study. "
07/01/2006 - "The aim of this study is to present surgical techniques and results of endoscope-assisted transnasal approach (TNA) for pituitary adenomas. "
01/01/2015 - "By endoscopy, the nasal mucosa was incised in the nasal septum, and all mucosal flaps were retained, a sub-septum-mucosa surgical corridor was made where the endoscope was used in the mucosa cavity for operation and to remove the pituitary adenoma. "