Pimozide (Orap)

A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

Also Known As:

Networked: 474 relevant articles (52 outcomes, 56 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Salamone, John D: 5 articles (11/2020 - 02/2005)
2.	Chen, Jia-Jie: 5 articles (07/2020 - 01/2016)
3.	Cai, Nan: 4 articles (09/2019 - 01/2016)
4.	Feng, Zhiwei: 3 articles (06/2020 - 09/2018)
5.	Guo, Jing: 3 articles (06/2020 - 09/2018)
6.	Jia, Huijie: 3 articles (06/2020 - 09/2018)
7.	Wei, Tian: 3 articles (06/2020 - 09/2018)
8.	Zhao, Tiesuo: 3 articles (06/2020 - 09/2018)
9.	Jankovic, Joseph: 3 articles (01/2020 - 05/2005)
10.	Cavanna, Andrea E: 3 articles (01/2019 - 12/2011)

Related Diseases

1.	Tourette Syndrome (Tourette's Syndrome) 03/01/1984 - "Controlled study of pimozide vs. placebo in Tourette's syndrome." 01/01/2016 - "Timing recalibration in childhood Tourette syndrome associated with persistent pimozide treatment." 10/01/1987 - "Significant interindividual variability of pimozide pharmacokinetics was found in both adults and children with Tourette's syndrome. " 10/01/1987 - "Mean elimination half-life of pimozide in children was 66 hours compared with 111 hours in adults with Tourette's syndrome. " 10/01/1987 - "A comparison of the pharmacokinetics of pimozide was made in children and adults with Tourette's syndrome. "
2.	Schizophrenia (Dementia Praecox) 01/01/1979 - "Brief representative case histories are presented, and dosage recommendations for the effective treatment of acute schizophrenia with pimozide are discussed." 01/01/1979 - "It is concluded that oral pimozide is an effective treatment for the whole range of symptoms accompanying acute schizophrenia. " 01/01/2000 - "All randomised trials relating to people with schizophrenia, or similar disorders comparing pimozide to other drug treatments were sought. " 01/01/2000 - "All randomised trials relating to people with schizophrenia, or similar disorders comparing pimozide to other drug treatments were sought. " 01/01/1977 - "Open study to determine appropriate maintenance dosage of pimozide in patients with chronic schizophrenia."
3.	Tics (Tic) 03/10/1999 - "Chronic, longer term treatment with pimozide appears to be more effective in controlling the course of tics than using the drug acutely to treat an exacerbation." 06/01/1989 - "However, pimozide proved immediately effective in suppressing tics and this improvement was maintained at follow-up. " 06/01/1987 - "Pimozide treatment of tic and Tourette disorders." 04/15/2009 - "Pimozide is an effective treatment for tics in Tourette Syndrome, though the number of trials comparing its effect to placebo and other drugs is limited. " 01/01/2020 - "We also found that the diphenylbutylpiperidine pimozide, which is approved to suppress tics in individuals with Tourette syndrome, is a SCOT antagonist. "
4.	Paranoid Schizophrenia (Delusional Disorder) 01/01/1993 - "Some reports indicate that at least pimozide may be effective in delusional disorder as well. " 02/01/1998 - "1. The effects of pimozide on the psychopathology of delusional disorder were studied. " 02/01/1998 - "Effects of pimozide on the psychopathology of delusional disorder." 02/01/1993 - "A case of querulous-litigious delusional disorder successfully treated with low-dose pimozide is reported. " 10/01/1992 - "We believe pimozide's established benefit in the treatment of delusional disorders warrants its consideration in alleviating other delusions, including "the delusion of doubles.""
5.	Neoplasms (Cancer) 01/01/2021 - "Compared to 99mTc-MPHH, the 99mTc-PHH exhibited a significantly increased tumor uptake at 15 and 60 min, but the rapid blood clearance of 99mTc-MPHH led to enhanced tumor-to-muscle ratios at 240 min. A significant reduction in tumor uptake 60 min after an injection of pimozide (5-HT7 receptor antagonist) confirms the tumor uptake was receptor-mediated specifically. " 06/01/2020 - "These all indicated that the combination treatment improved the anti-tumor effect of pimozide on mice. " 11/30/2023 - "The injection of pimozide can block the tumor's radiotracer uptake, indicating the binding of these radiotracers to the 5-HT7R. " 01/01/2023 - "The injection of pimozide blocks the receptors and significantly reduces the tumor-to-muscle ratios at 1-hour post-injection to 0.81 and 0.31, respectively. " 06/01/2022 - "Pimozide, an inhibitor of APRC2, also inhibited the promoting effect of EVs of metastatic cells in lung colonization of tumor cells in mice. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Haloperidol (Haldol)
3.	Risperidone (Risperdal Consta)
4.	Apomorphine
5.	Dopamine Receptors (Dopamine Receptor)
6.	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)
7.	Sulpiride (neogama)
8.	Chlorpromazine (Thorazine)
9.	Clozapine (Clozaril)
10.	Dopamine Antagonists

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Injections
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration