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Picryl Chloride (Trinitrochlorobenzene)

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A hapten that generates suppressor cells capable of down-regulating the efferent phase of trinitrophenol-specific contact hypersensitivity. (Arthritis Rheum 1991 Feb;34(2):180).

Also Known As:

Trinitrochlorobenzene; 1-Chloro-2,4,6-trinitrobenzene; Chloride, Picryl; 2,4,6-Trinitro-1-chlorobenzene; Benzene, 2-chloro-1,3,5-trinitro-

Networked: 307 relevant articles (2 outcomes, 19 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Xu, Qiang: 13 articles (03/2009 - 02/2002)
2.	Sun, Yang: 7 articles (03/2009 - 06/2003)
3.	Chen, Ting: 6 articles (03/2009 - 05/2003)
4.	Xu, Q: 5 articles (06/2008 - 11/2000)
5.	Inoue, Yoshifumi: 5 articles (11/2003 - 10/2002)
6.	Hayashi, Hideya: 5 articles (11/2003 - 10/2002)
7.	Isobe, Yoshiaki: 4 articles (12/2003 - 10/2002)
8.	Isobe, Masakazu: 4 articles (11/2003 - 01/2003)
9.	Matsuda, Hideaki: 3 articles (10/2009 - 06/2002)
10.	Manabe, Haruhiko: 3 articles (01/2009 - 03/2005)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 01/01/2006 - "mAgK114 suppresses lymphocyte infiltration into epidermis in the picryl chloride-induced atopic dermatitis-like skin lesions of NC/Nga mice." 10/01/2003 - "[Analysis of scratching behavior in a picryl chloride induced atopic dermatitis model in mice]" 02/28/2008 - "In the present study, to investigate whether TCDD exacerbates atopic dermatitis-like skin lesions elicited in NC/Nga mice, NC/Nga mice were applied with picryl chloride (PC), and then were exposed to a single oral dose of 0 (control), 5, and 20 microg TCDD/kg. Two weeks later, spleens, blood, and skin specimens were collected. " 06/01/2007 - "We examined whether the extract from Hatakeshimeji (Lyophyllum decastes, LD) mushrooms suppresses the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. " 01/01/2006 - "MATERIALS AND METHODS: Whether mAgK114 supresses the development, in NC/Nga mice, of atopic dermatitis (AD)-like skin lesions induced by repeated application of 2,4,6-trinitrochlorobenzene (picryl chloride, PiCl) was examined under specific pathogen-free conditions. " Order ALL the reference details at left...
2.	Dermatitis 03/01/2005 - "OBJECTIVE: The purpose of this study is to provide more detailed analysis of the model of chronic dermatitis caused by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB). " 03/01/2005 - "Analyses of a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application." 06/01/2000 - "Picryl chloride-induced allergic dermatitis in IQI/Jic female mice." 01/01/1981 - "Flare-up of contract dermatitis to picryl chloride in the mouse." 02/17/2006 - "The purpose of this study was to evaluate the efficacy of rolipram, a phosphodiesterase (PDE) 4 inhibitor, in a mouse model of dermatitis induced by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB). " Order ALL the reference details at left...
3.	Inflammation 05/01/2006 - "METHODS: By using the mouse model of LZT, we analyzed immune reactions in vivo (skin inflammation) and T-cell responses in vitro after oral, intravenous, or epicutaneous application of low amounts of the contact allergen 2,4,6-trinitro-1-chlorobenzene (TNCB). " 03/01/1997 - "The irritant reaction is a model of local inflammation that results from the epicutaneous application of a small molecule with irritating properties such as trinitrochlorobenzene (TNCB). " 12/01/1982 - "After selection of the 3%-concentration of picryl chloride for challenge on ear, attempts were made to modulate these two types of reaction pharmacologically with various anti-allergic or anti-inflammatory compounds mixed with the inflammation-inducing agent. " 12/01/1982 - "Seven days after contact sensitization of the animals on their shaved abdomen, the immune inflammation was also induced on an ear by various doses of picryl chloride. " 12/01/1982 - "Modulation by various locally applied anti-inflammatory and anti-allergic compounds of the immune and non-immune inflammation induced by picryl chloride in mice." Order ALL the reference details at left...
4.	Skin Diseases 01/01/2008 - "The present study was performed to examine whether the leaves of Saururus chinensis (LOUR.) BAILL (SC), an herb used for the management of various skin diseases including atopic dermatitis (AD) in Eastern countries, inhibited the development of AD-like skin lesions in NC/Nga mice which was induced by repeated application of picryl chloride (PiCl). " 01/01/2009 - "To evaluate efficacy of KF66490 in atopic dermatitis (AD) models, on skin inflammation induced by repeated application of 2,4,6-trinitro-1-chlorobenzene (TNCB) on ear in BALB/c mice and on spontaneously AD-like skin diseases in NC/Nga mice. " Order ALL the reference details at left...
5.	Contact Dermatitis (Eczema, Contact) 11/01/1999 - "These studies suggest that mast cells are critical to the processes by which cis-UCA suppresses systemic contact hypersensitivity responses to the hapten, trinitrochlorobenzene, in mice." 06/01/1991 - "The present study has further characterized the T cell-mediated inflammatory response of contact sensitivity (CS) to the hapten trinitrochlorobenzene (TNCB) in mice. " 02/01/1990 - "Our earlier studies have demonstrated that intragastric administration of the hapten trinitrochlorobenzene (TNCB) 2 to 3 weeks prior to attempting sensitization with epidermally applied hapten can abrogate development of systemic contact sensitivity (CS). " 06/01/1981 - "Studies on the genetic control of picryl chloride contact hypersensitivity reaction in inbred rats." 03/13/2009 - "MAIN METHODS: Contact dermatitis was induced in mice with picryl chloride. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Rolipram
2.	4- cyano- 4- (2,3- dihydro- 8- methoxy- 1,4- benzodioxin- 5- yl)cyclohexanecarboxylic acid
3.	Antigens
4.	Oxazolone
5.	Dinitrofluorobenzene
6.	pinacolyl methylphosphonochloridate (PICL)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Carrageenan
9.	Interleukin-4 (Interleukin 4)
10.	Uracil

Related Therapies and Procedures

1.	Oral Administration
2.	Thymectomy
3.	Injections
4.	Transplants (Transplant)
5.	Electroacupuncture

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