|1.||Brabec, Viktor: 2 articles (02/2011 - 11/2003)|
|2.||Alonso, Carlos: 2 articles (01/2006 - 01/2006)|
|3.||Navarro-Ranninger, Carmen: 2 articles (01/2006 - 11/2002)|
|4.||Najajreh, Yousef: 2 articles (11/2003 - 11/2002)|
|5.||Gibson, Dan: 2 articles (11/2003 - 11/2002)|
|6.||Helios, Katarzyna: 1 article (08/2014)|
|7.||Zierkiewicz, Wiktor: 1 article (08/2014)|
|8.||Wysokiński, Rafał: 1 article (08/2014)|
|9.||Malik, Magdalena: 1 article (08/2014)|
|10.||Michalska, Danuta: 1 article (08/2014)|
04/15/1989 - "Preclinical antitumor activity of an alpha-picoline derivative, penclomedine (NSC 338720), on human and murine tumors."
08/01/2003 - "Penclomedine (PEN), a multichlorinated alpha-picoline derivative which is metabolized to highly reactive alkylating species, was selected for clinical development due to its prominent activity against a wide range of human tumor xenografts when administered either parentally or orally. "
06/01/1998 - "Penclomedine is a multi-chlorinated alpha-picoline derivative that has demonstrated activity in several murine breast cancer models and is currently in clinical testing for use against solid tumors. "
08/28/2014 - "Picoplatin, cis-[PtCl2(NH3)(2-picoline)], is a new promising anticancer agent undergoing clinical trials, which reveals high efficacy against many tumors and greatly reduced toxicity, in comparison to cisplatin. "
01/12/2006 - "Cellular pharmacological properties of eight trans-picoline platinum(II) complexes of formula trans-[PtX(2)(L)(L')], where X = Cl or CH(3)COO (OAc) and L = L' = 3-picoline (3-pic), 4-picoline (4-pic) or L = NH(3) and L' = 3-pic or 4-pic, were investigated in murine keratinocyte Pam 212 cells and Pam 212-ras cells, murine tumor keratinocytes derived from transformation with a viral vector containing the H-ras oncogene. "
|2.||Ovarian Neoplasms (Ovarian Cancer)
02/16/2011 - "Complexes conjugated to Arg(5) or Arg(8) at the 5-position of the picoline ring increase Os uptake into A2780 human ovarian cancer cells by ca. 2× and 10×, respectively, whereas a single Arg had no effect. "
11/01/2003 - "Replacement of the ammine group in antitumor cisplatin by a heterocyclic ligand (piperidine, piperazine, or 4-picoline) results in reduction of cytotoxicity in human ovarian cancer cells. "
11/21/2002 - "Positively charged, water soluble cis/trans-[PtCl(2)(piperazine)(Am1)] (where Am1 = NH(3), n-butylamine, isopropylamine, 4-picoline, piperidine, and piperazine) has significant cytotoxic activity against cisplatin resistant ovarian cancer cells. "
|5.||Breast Neoplasms (Breast Cancer)
|2.||amminedichloro(2- methylpyridine)platinum(II) (ZD0473)
|4.||Platinum Compounds (Compounds, Platinum)
|10.||carboxyl radical (COO-)
|1.||Heterologous Transplantation (Xenotransplantation)