Obesity Hypoventilation Syndrome (Pickwickian Syndrome)

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71 relevant articles (6 outcomes, 3 trials/studies) found for this Disease

Description: HYPOVENTILATION syndrome in very obese persons with excessive ADIPOSE TISSUE around the ABDOMEN and DIAPHRAGM. It is characterized by diminished to absent ventilatory chemoresponsiveness; chronic HYPOXIA; HYPERCAPNIA; POLYCYTHEMIA; and long periods of sleep during day and night (HYPERSOMNOLENCE). It is a condition often related to OBSTRUCTIVE SLEEP APNEA but can occur separately.

Also Known As:

Pickwickian Syndrome; Syndrome, Pickwickian; Hypoventilation Syndrome, Obesity; Syndrome, Obesity Hypoventilation

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypoventilation
2.	Obstructive Sleep Apnea
3.	Weight Loss (Weight Reduction)
4.	Sleep Apnea Syndromes (Sleep Apnea)
5.	Hypertension (High Blood Pressure)

Experts

1.	Grunstein, Ronald R: 2 articles (06/2007 - 01/2006)
2.	Yee, Brendon J: 2 articles (06/2007 - 01/2006)
3.	Piper, Amanda J: 2 articles (06/2007 - 01/2006)
4.	Banerjee, Dev: 2 articles (06/2007 - 01/2006)
5.	Redolfi, Stefania: 1 article (06/2007)
6.	Dobroschke, Jakob: 1 article (06/2007)
7.	Heinemann, Frank: 1 article (06/2007)
8.	Budweiser, Stephan: 1 article (06/2007)
9.	Corda, Luciano: 1 article (06/2007)
10.	Pfeifer, Michael: 1 article (06/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Obesity Hypoventilation Syndrome:

1.	Carbon MonoxideIBA 05/01/2009 - "The male MC patients had more prevalent co-morbidities than did the male NMC patients (hypertension 79.17% versus 58.85%; diabetes mellitus 36.11% versus 24.83%; obstructive sleep apnea 79.17% versus 54.51%; and obesity hypoventilation syndrome 26.39% versus 7.64%). " 05/01/2009 - "The co-morbidities were greater in the MC patients than in the NMC patients (hypertension 71.9% versus 48.4%, diabetes mellitus 39.72% versus 19.4%, obstructive sleep apnea 46.45% versus 28.46%, and obesity hypoventilation syndrome 9.93% versus 2.71%). " 01/01/2004 - "In the presence of more profound daytime hypercapnia, polysomnography should be considered (over nocturnal pulse oximetry) to rule out other co-existing sleep-related breathing disorders such as obstructive sleep apnea (overlap syndrome) and obesity hypoventilation syndrome. " 01/01/2006 - "However, apart from the fact that Joe's Picwickian syndrome ("the obesity hypoventilation syndrome") needs to be differentiated from true OSAS, already in the Hippocratic Corpus (V-IV century BC) many clues regarding apnea and sleepiness are present, and in 79 AD the Roman author Pliny the Younger clearly reported the death of a man in whom obesity, sleepiness and snoring were co-present in a unique clinical picture. " 07/01/1999 - "OBJECTIVE: To define the role of breathing control in the pathogenesis of carbon dioxide (CO(2)) retention in patients with obesity hypoventilation syndrome. " Order ALL the reference details at left...
2.	Carbon DioxideIBA 07/01/1999 - "[The role of breathing control disorder in the development of carbon dioxide retention in patients with obesity hypoventilation syndrome]" 07/01/1983 - "Thus, the decreased neuromuscular responsiveness to carbon dioxide (mouth-occlusion pressure/end-tidal carbon dioxide pressure) among the group with former obesity-hypoventilation syndrome when compared with that in the group with simple obesity is a consequence of a blunted neural (central) drive, and not due to any apparent worse mechanical limitations. " 11/01/1980 - "The obesity hypoventilation syndrome in children with the Prader-Willi syndrome: a possible role for familial decreased response to carbon dioxide." 05/01/1999 - "As obesity becomes more pronounced some individuals are unable to compensate, leading to elevated arterial carbon dioxide levels (PaCO2), alveolar hypoventilation, and increased cardiorespiratory morbidity and mortality (Pickwickian syndrome). " 07/01/1999 - "OBJECTIVE: To define the role of breathing control in the pathogenesis of carbon dioxide (CO(2)) retention in patients with obesity hypoventilation syndrome. " Order ALL the reference details at left...
3.	HormonesIBA 05/02/1992 - "It is treated by weight reduction (pickwickian syndrome), hormones, or recently, with continuous positive pressure apparatus. " 07/01/2001 - "In most patients, surgically induced weight loss will correct hypertension, type II diabetes mellitus, sleep apnea, obesity hypoventilation syndrome, gastroesophageal reflux, venous stasis disease, urinary incontinence, female sexual hormone dysfunction, pseudotumor cerebri, degenerative joint disease pains, as well as improved self-image and employability." Order ALL the reference details at left...
4.	Medroxyprogesterone 17-Acetate (Depo-Provera)FDA LinkGeneric 10/01/1975 - "We conclude that sublingual medroxyprogesterone acetate therapy is useful in the management of the Pickwickian syndrome." 10/01/1975 - "Ten patients with the Pickwickian syndrome, characterized by obesity, hypoxemia, hypercapnia, polycythemia, and cor pulmonale, underwent long-term treatment as outpatients with medroxyprogesterone acetate. " Order ALL the reference details at left...
5.	OxygenIBA 03/01/1981 - "The two patients with the most frequent episodes of apnea and lowest oxygen saturation had a clinical picture consistent with the pickwickian syndrome. " 11/01/1985 - "Oxygen will probably serve more an adjunctive role in therapy, and medroxyprogesterone appears to be beneficial only in the treatment of the obesity-hypoventilation syndrome. " 12/01/2000 - "The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of <93%). " Order ALL the reference details at left...
6.	Interleukin-6 (Interleukin 6)IBA 12/01/2000 - "The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of <93%). " Order ALL the reference details at left...
7.	LeptinIBA 08/01/2007 - "Raised leptin levels have been reported in subjects with sleep apnoea or obesity-hypoventilation syndrome. " 06/01/2007 - "Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome." 01/01/2006 - "Treatment of obesity hypoventilation syndrome and serum leptin." 01/01/2002 - "It was hypothesised that a relative deficiency in CNS leptin, indicated by high circulating leptin levels, may be implicated in the pathogenesis of obesity hypoventilation syndrome (OHS). " 01/01/2002 - "Leptin and the obesity hypoventilation syndrome: a leap of faith?" Order ALL the reference details at left...
8.	SASIBA 06/01/1987 - "In its most severe form, when both SAS and OHS are present, it is called the Pickwickian syndrome. " 07/01/1986 - "This can be divided into the following two primary breathing disorders which can affect patients alone or in combination: the obstructive sleep apnea syndrome (SAS); and the obesity-hypoventilation syndrome (OHS). " 01/01/1997 - "This article gives a brief historical overview of the literature on the sleep apnea syndrome (SAS), including initial case reports of the Pickwickian syndrome and its treatment with tracheostomy. " 02/01/1992 - "The Pickwickian syndrome can be divided into two primary breathing disorders, which can affect patients alone or in combination: sleep apnea syndrome (SAS) and obesity hypoventilation syndrome (OHS). " 06/01/1987 - "Respiratory insufficiency of obesity can be divided into two primary breathing disorders: the obstructive sleep apnea syndrome (SAS) and the obesity hypoventilation syndrome (OHS). " Order ALL the reference details at left...
9.	Progesterone FDA LinkGeneric 11/01/1985 - "Progesterone seems to be of some help in patients who have obesity hypoventilation syndrome. " 03/01/1977 - "Progesterone treatment of the obesity hypoventilation syndrome in a child." 01/01/1977 - "Progesterone for the Pickwickian syndrome: respiratory implications: a case report." 10/01/1975 - "Progesterone for outpatient treatment of Pickwickian syndrome." Order ALL the reference details at left...
10.	Oxyhemoglobins (Oxyhemoglobin)IBA 07/01/1985 - "Oxyhemoglobin saturation during sleep in subjects with and without the obesity-hypoventilation syndrome." 01/01/2008 - "Current recommendations follow: (1) APAP devices are not recommended to diagnose OSA; (2) patients with congestive heart failure, patients with significant lung disease such as chronic obstructive pulmonary disease; patients expected to have nocturnal arterial oxyhemoglobin desaturation due to conditions other than OSA (e.g., obesity hypoventilation syndrome); patients who do not snore (either naturally or as a result of palate surgery); and patients who have central sleep apnea syndromes are not currently candidates for APAP titration or treatment; (3) APAP devices are not currently recommended for split-night titration; (4) certain APAP devices may be used during attended titration with polysomnography to identify a single pressure for use with standard CPAP for treatment of moderate to severe OSA; (5) certain APAP devices may be initiated and used in the self-adjusting mode for unattended treatment of patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (6) certain APAP devices may be used in an unattended way to determine a fixed CPAP treatment pressure for patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (7) patients being treated with fixed CPAP on the basis of APAP titration or being treated with APAP must have close clinical follow-up to determine treatment effectiveness and safety; and (8) a reevaluation and, if necessary, a standard attended CPAP titration should be performed if symptoms do not resolve or the APAP treatment otherwise appears to lack efficacy." Order ALL the reference details at left...

Therapies and Procedures

1.	Continuous Positive Airway Pressure 07/01/1983 - "Remission of severe obesity-hypoventilation syndrome after short-term treatment during sleep with nasal continuous positive airway pressure." 05/01/2008 - "An emerging application is to treat obesity-hypoventilation syndrome, particularly in continuous positive airway pressure (CPAP) failures. " 06/01/2007 - "Positive airway pressure titration in obesity hypoventilation syndrome: continuous positive airway pressure or bilevel positive airway pressure." 01/01/2007 - "She was eventually diagnosed with Pickwickian syndrome or OHS and received treatment with continuous positive airway pressure (CPAP). " 03/01/2003 - "Nasal continuous positive airway pressure improves quality of life in obesity hypoventilation syndrome." Order ALL the reference details at left...
2.	Artificial Respiration (Mechanical Ventilation) 04/01/2001 - "STUDY OBJECTIVES: To assess the effectiveness of nasal noninvasive mechanical ventilation (NIMV) in patients with obesity hypoventilation syndrome (OHS). " 01/01/2007 - "Obesity-hypoventilation syndrome and noninvasive mechanical ventilation: new insights in the Pickwick papers?" 07/01/2003 - "[Analysis of withdrawal from noninvasive mechanical ventilation in patients with obesity-hypoventilation syndrome. " 04/01/2001 - "The obesity hypoventilation syndrome can be treated with noninvasive mechanical ventilation." 07/01/2003 - "OBJECTIVE: To evaluate the possibility of cessation of noninvasive mechanical ventilation or noninvasive positive pressure ventilation (NPPV) treatment in patients with obesity-hypoventilation syndrome (OHS). " Order ALL the reference details at left...
3.	Positive-Pressure Respiration (PEEP) 06/01/2007 - "BACKGROUND: Our objective was to study the long-term effects of non-invasive positive pressure ventilation (NPPV) on lung function and gas exchange in patients with the obesity hypoventilation syndrome (OHS). " 01/01/2008 - "BACKGROUND: Obesity hypoventilation syndrome (OHS) can be treated with noninvasive positive pressure ventilation (NIPPV). " 06/01/2007 - "Non-invasive positive pressure ventilation improves lung volumes in the obesity hypoventilation syndrome." 01/10/2004 - "[Obesity hypoventilation syndrome (OHS) successfully treated with non-invasive positive pressure ventilation (NIPPV)]" 07/01/2003 - "OBJECTIVE: To evaluate the possibility of cessation of noninvasive mechanical ventilation or noninvasive positive pressure ventilation (NPPV) treatment in patients with obesity-hypoventilation syndrome (OHS). " Order ALL the reference details at left...
4.	Tracheostomy 06/13/1969 - "[Successful management of Pickwickian syndrome using long-term tracheostomy]" 03/01/2009 - "In an effort to avoid a tracheostomy for worsening pickwickian syndrome, he was referred for weight loss surgery. " 07/01/1996 - "The clinical course and changes in hypercapnic ventilatory drive over time were serially assessed before and after tracheostomy placement in a 14 year old, morbidly obese female patient with Prader-Willi syndrome, severe obstructive sleep apnoea, and obesity-hypoventilation syndrome. " 09/01/1991 - "The role of tracheostomy is limited in the obesity hypoventilation syndrome unless severe upper airway obstruction exists. " 07/01/1989 - "In addition to the tracheostomy, we propose that implantation of a cardiac permanent pacemaker should be selected for the bradyarrhythmias in association with the Pickwickian syndrome." Order ALL the reference details at left...
5.	Gastroplasty (Vertical-Banded Gastroplasty) 03/01/1991 - "Under these considerations, gastroplasty is a beneficial surgical treatment for the morbid obesity with Pickwickian syndrome." 03/01/1991 - "He was diagnosed as morbid obesity with Pickwickian syndrome and underwent vertical banded gastroplasty. " 03/01/1991 - "[A case of Pickwickian syndrome with improvement of obesity-related sleep apnea following vertical banded gastroplasty]" 06/01/1981 - "Three patients with the obesity hypoventilation syndrome and one patient with the sleep apnea syndrome underwent gastroplasty for weight reduction. " Order ALL the reference details at left...

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