|2.||Obstructive Sleep Apnea
|3.||Neuromuscular Diseases (Neuromuscular Disease)
|4.||Sleep Apnea Syndromes (Sleep Apnea)
|5.||Weight Loss (Weight Reduction)
|1.||Piper, Amanda J: 4 articles (05/2014 - 01/2006)|
|2.||Monneret, Denis: 3 articles (11/2015 - 04/2010)|
|3.||Contal, Olivier: 3 articles (07/2015 - 01/2013)|
|4.||Adler, Dan: 3 articles (07/2015 - 01/2013)|
|5.||Janssens, Jean-Paul: 3 articles (07/2015 - 11/2008)|
|6.||Grunstein, Ronald R: 3 articles (05/2014 - 01/2006)|
|7.||Yee, Brendon J: 3 articles (05/2014 - 01/2006)|
|8.||Esquinas, Antonio M: 3 articles (05/2013 - 02/2013)|
|9.||Borel, Jean-Christian: 3 articles (01/2013 - 04/2010)|
|10.||Pépin, Jean-Louis: 2 articles (07/2015 - 01/2013)|
11/01/2014 - "Obesity hypoventilation syndrome in Japan and independent determinants of arterial carbon dioxide levels."
07/01/1983 - "Thus, the decreased neuromuscular responsiveness to carbon dioxide (mouth-occlusion pressure/end-tidal carbon dioxide pressure) among the group with former obesity-hypoventilation syndrome when compared with that in the group with simple obesity is a consequence of a blunted neural (central) drive, and not due to any apparent worse mechanical limitations. "
11/01/1980 - "The obesity hypoventilation syndrome in children with the Prader-Willi syndrome: a possible role for familial decreased response to carbon dioxide."
05/01/1999 - "As obesity becomes more pronounced some individuals are unable to compensate, leading to elevated arterial carbon dioxide levels (PaCO2), alveolar hypoventilation, and increased cardiorespiratory morbidity and mortality (Pickwickian syndrome). "
05/01/2012 - "Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity (body mass index ≥ 30 kg/m(2)), daytime hypercapnia (partial arterial carbon dioxide concentration ≥45 mm Hg) and sleep-disordered breathing after ruling out other disorders that may cause alveolar hypoventilation. "
04/01/2012 - "The combination of ventilatory impairment, excess CO(2) production and reduced ventilatory drive predisposes obese individuals to obesity hypoventilation syndrome."
01/01/2013 - "The overlap syndrome of obstructive sleep apnoea (OSA) and chronic obstructive pulmonary disease (COPD), in addition to obesity hypoventilation syndrome, represents growing health concerns, owing to the worldwide COPD and obesity epidemics and related co-morbidities. "
01/01/2004 - "In the presence of more profound daytime hypercapnia, polysomnography should be considered (over nocturnal pulse oximetry) to rule out other co-existing sleep-related breathing disorders such as obstructive sleep apnea (overlap syndrome) and obesity hypoventilation syndrome. "
05/01/2009 - "The male MC patients had more prevalent co-morbidities than did the male NMC patients (hypertension 79.17% versus 58.85%; diabetes mellitus 36.11% versus 24.83%; obstructive sleep apnea 79.17% versus 54.51%; and obesity hypoventilation syndrome 26.39% versus 7.64%). "
05/01/2009 - "The co-morbidities were greater in the MC patients than in the NMC patients (hypertension 71.9% versus 48.4%, diabetes mellitus 39.72% versus 19.4%, obstructive sleep apnea 46.45% versus 28.46%, and obesity hypoventilation syndrome 9.93% versus 2.71%). "
05/02/1992 - "It is treated by weight reduction (pickwickian syndrome), hormones, or recently, with continuous positive pressure apparatus. "
07/01/2001 - "In most patients, surgically induced weight loss will correct hypertension, type II diabetes mellitus, sleep apnea, obesity hypoventilation syndrome, gastroesophageal reflux, venous stasis disease, urinary incontinence, female sexual hormone dysfunction, pseudotumor cerebri, degenerative joint disease pains, as well as improved self-image and employability."
05/01/2011 - "Oxygen for obesity hypoventilation syndrome: a double-edged sword?"
04/01/2014 - "Moderate concentrations of supplemental oxygen worsen hypercapnia in obesity hypoventilation syndrome: a randomised crossover study."
03/01/1981 - "The two patients with the most frequent episodes of apnea and lowest oxygen saturation had a clinical picture consistent with the pickwickian syndrome. "
09/01/2015 - "Rapid oxygen desaturation may occur as a result of brief moments of apnea from even minimal amounts of sedating medications, due to poor baseline functional reserve as well as common comorbid conditions such as obstructive sleep apnea and obesity hypoventilation syndrome. "
06/01/2015 - "Supplemental oxygen is commonly used to treat chronic hypoxemia but carries some risk in obese individuals due to unrecognized comorbid obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS). "
|5.||Interleukin-6 (Interleukin 6)IBA
12/01/2000 - "The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of <93%). "
01/01/2015 - "Very high levels of leptin, however, are associated with the depressed ventilatory phenotype observed in obesity hypoventilation syndrome. "
08/01/2007 - "Raised leptin levels have been reported in subjects with sleep apnoea or obesity-hypoventilation syndrome. "
06/01/2007 - "Long-term non-invasive ventilation increases chemosensitivity and leptin in obesity-hypoventilation syndrome."
01/01/2006 - "Treatment of obesity hypoventilation syndrome and serum leptin."
01/01/2002 - "It was hypothesised that a relative deficiency in CNS leptin, indicated by high circulating leptin levels, may be implicated in the pathogenesis of obesity hypoventilation syndrome (OHS). "
06/01/1987 - "In its most severe form, when both SAS and OHS are present, it is called the Pickwickian syndrome. "
07/01/1986 - "This can be divided into the following two primary breathing disorders which can affect patients alone or in combination: the obstructive sleep apnea syndrome (SAS); and the obesity-hypoventilation syndrome (OHS). "
01/01/1997 - "This article gives a brief historical overview of the literature on the sleep apnea syndrome (SAS), including initial case reports of the Pickwickian syndrome and its treatment with tracheostomy. "
02/01/1992 - "The Pickwickian syndrome can be divided into two primary breathing disorders, which can affect patients alone or in combination: sleep apnea syndrome (SAS) and obesity hypoventilation syndrome (OHS). "
06/01/1987 - "Respiratory insufficiency of obesity can be divided into two primary breathing disorders: the obstructive sleep apnea syndrome (SAS) and the obesity hypoventilation syndrome (OHS). "
09/01/1972 - "Lung volumes, mechanics of breathing and changes in arterial blood gases in obese patients and in Pickwickian syndrome."
05/15/2014 - "We measured overnight polysomnography (PSG), arterial blood gases, and Epworth Sleepiness Scale in 55 severe SDB patients with obesity hypoventilation syndrome or overlap syndrome (COPD+ obstructive sleep apnea) before and ∼3 months after positive airway pressure (PAP) treatment. "
08/15/2013 - "This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide P CO2, pH and bicarbonate (HCO3(-)) in people with obesity hypoventilation syndrome (OHS). "
07/01/1985 - "Oxyhemoglobin saturation during sleep in subjects with and without the obesity-hypoventilation syndrome."
01/01/2008 - "Current recommendations follow: (1) APAP devices are not recommended to diagnose OSA; (2) patients with congestive heart failure, patients with significant lung disease such as chronic obstructive pulmonary disease; patients expected to have nocturnal arterial oxyhemoglobin desaturation due to conditions other than OSA (e.g., obesity hypoventilation syndrome); patients who do not snore (either naturally or as a result of palate surgery); and patients who have central sleep apnea syndromes are not currently candidates for APAP titration or treatment; (3) APAP devices are not currently recommended for split-night titration; (4) certain APAP devices may be used during attended titration with polysomnography to identify a single pressure for use with standard CPAP for treatment of moderate to severe OSA; (5) certain APAP devices may be initiated and used in the self-adjusting mode for unattended treatment of patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (6) certain APAP devices may be used in an unattended way to determine a fixed CPAP treatment pressure for patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (7) patients being treated with fixed CPAP on the basis of APAP titration or being treated with APAP must have close clinical follow-up to determine treatment effectiveness and safety; and (8) a reevaluation and, if necessary, a standard attended CPAP titration should be performed if symptoms do not resolve or the APAP treatment otherwise appears to lack efficacy."
|1.||Positive-Pressure Respiration (PEEP)
01/01/2013 - "Impact of different backup respiratory rates on the efficacy of noninvasive positive pressure ventilation in obesity hypoventilation syndrome: a randomized trial."
06/01/2007 - "Our objective was to study the long-term effects of non-invasive positive pressure ventilation (NPPV) on lung function and gas exchange in patients with the obesity hypoventilation syndrome (OHS). "
04/01/2013 - "Backup respiratory rate during noninvasive positive pressure ventilation in obesity hypoventilation syndrome: can this difficult puzzle be resolved?"
07/01/2010 - "Few data are available on the long-term outcome of noninvasive positive pressure ventilation (NPPV) for obesity hypoventilation syndrome (OHS). "
07/01/2010 - "Long-term outcome of noninvasive positive pressure ventilation for obesity hypoventilation syndrome."
|2.||Continuous Positive Airway Pressure
07/01/1983 - "Remission of severe obesity-hypoventilation syndrome after short-term treatment during sleep with nasal continuous positive airway pressure."
10/01/2013 - "The use of continuous positive airway pressure (CPAP) treatment in patients with obesity hypoventilation syndrome (OHS) and obstructive sleep apnoea (OSA) was evaluated, and factors that might predict CPAP treatment failure were determined. "
10/01/2013 - "Continuous positive airway pressure in clinically stable patients with mild-to-moderate obesity hypoventilation syndrome and obstructive sleep apnoea."
09/20/2013 - "Airway pressure release ventilation as a therapeutic approach in a patient with severe obesity hypoventilation syndrome and restrictive lung impairment."
05/01/2008 - "An emerging application is to treat obesity-hypoventilation syndrome, particularly in continuous positive airway pressure (CPAP) failures. "
|3.||Artificial Respiration (Mechanical Ventilation)
02/01/2015 - "Noninvasive mechanical ventilation in patients with obesity hypoventilation syndrome. "
02/01/2013 - "Non-invasive mechanical ventilation in obesity hypoventilation syndrome: are multimodal therapeutic strategies disease essential?"
01/01/2007 - "Obesity-hypoventilation syndrome and noninvasive mechanical ventilation: new insights in the Pickwick papers?"
07/01/2003 - "[Analysis of withdrawal from noninvasive mechanical ventilation in patients with obesity-hypoventilation syndrome. "
04/01/2001 - "To assess the effectiveness of nasal noninvasive mechanical ventilation (NIMV) in patients with obesity hypoventilation syndrome (OHS). "
|4.||Mechanical Ventilators (Ventilator)
07/01/2015 - "In stable subjects with obesity-hypoventilation syndrome, the home ventilator software tested was appropriate for determining if control of respiratory events was satisfactory on NIV or if further testing or adjustment of ventilator settings was required. "
12/01/2013 - "27 PSG tracings under NIV recorded in 9 stable patients with Obesity Hypoventilation Syndrome (OHS), under 3 different ventilator modes (no back-up rate, low or high back-up rate) were analyzed. "
07/01/2015 - "In this study, we aimed to compare apnea-hypopnea indices (AHI) provided by home ventilators (AHINIV) versus data scored manually during polysomnography (AHIPSG) in subjects on noninvasive ventilation (NIV) for obesity-hypoventilation syndrome. "
07/01/2015 - "Patients with acute on chronic respiratory failure (ACRF) with underlying chronic obstructive pulmonary disease (COPD) demonstrate different levels of comfort in response to varying ventilator settings compared to those with underlying obesity hypoventilation syndrome (OHS). "
03/01/2012 - "The ongoing debate on the relevance of obesity, for example in terms of obstructive sleep apnea syndrome, obesity hypoventilation syndrome, and other related respiratory disturbances, in relation to the choice of analgesic techniques, especially interscalene block, patient-controlled intravenous analgesia and patient monitoring, demands large-scale, well-designed studies to resolve it. "