HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Obesity Hypoventilation Syndrome (Pickwickian Syndrome)

HYPOVENTILATION syndrome in very obese persons with excessive ADIPOSE TISSUE around the ABDOMEN and DIAPHRAGM. It is characterized by diminished to absent ventilatory chemoresponsiveness; chronic HYPOXIA; HYPERCAPNIA; POLYCYTHEMIA; and long periods of sleep during day and night (HYPERSOMNOLENCE). It is a condition often related to OBSTRUCTIVE SLEEP APNEA but can occur separately.
Also Known As:
Pickwickian Syndrome; Syndrome, Pickwickian; Hypoventilation Syndrome, Obesity; Syndrome, Obesity Hypoventilation
Networked: 110 relevant articles (6 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypoventilation
2. Obstructive Sleep Apnea
3. Neuromuscular Diseases (Neuromuscular Disease)
4. Sleep Apnea Syndromes (Sleep Apnea)
5. Weight Loss (Weight Reduction)

Experts

1. Piper, Amanda J: 4 articles (05/2014 - 01/2006)
2. Monneret, Denis: 3 articles (11/2015 - 04/2010)
3. Contal, Olivier: 3 articles (07/2015 - 01/2013)
4. Adler, Dan: 3 articles (07/2015 - 01/2013)
5. Janssens, Jean-Paul: 3 articles (07/2015 - 11/2008)
6. Grunstein, Ronald R: 3 articles (05/2014 - 01/2006)
7. Yee, Brendon J: 3 articles (05/2014 - 01/2006)
8. Esquinas, Antonio M: 3 articles (05/2013 - 02/2013)
9. Borel, Jean-Christian: 3 articles (01/2013 - 04/2010)
10. Pépin, Jean-Louis: 2 articles (07/2015 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Obesity Hypoventilation Syndrome:
1. Carbon DioxideIBA
2. Carbon MonoxideIBA
3. HormonesIBA
4. OxygenIBA
5. Interleukin-6 (Interleukin 6)IBA
6. LeptinIBA
7. SASIBA
8. ProgesteroneFDA LinkGeneric
9. GasesIBA
10. Oxyhemoglobins (Oxyhemoglobin)IBA
07/01/1985 - "Oxyhemoglobin saturation during sleep in subjects with and without the obesity-hypoventilation syndrome."
01/01/2008 - "Current recommendations follow: (1) APAP devices are not recommended to diagnose OSA; (2) patients with congestive heart failure, patients with significant lung disease such as chronic obstructive pulmonary disease; patients expected to have nocturnal arterial oxyhemoglobin desaturation due to conditions other than OSA (e.g., obesity hypoventilation syndrome); patients who do not snore (either naturally or as a result of palate surgery); and patients who have central sleep apnea syndromes are not currently candidates for APAP titration or treatment; (3) APAP devices are not currently recommended for split-night titration; (4) certain APAP devices may be used during attended titration with polysomnography to identify a single pressure for use with standard CPAP for treatment of moderate to severe OSA; (5) certain APAP devices may be initiated and used in the self-adjusting mode for unattended treatment of patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (6) certain APAP devices may be used in an unattended way to determine a fixed CPAP treatment pressure for patients with moderate to severe OSA without significant comorbidities (CHF, COPD, central sleep apnea syndromes, or hypoventilation syndromes); (7) patients being treated with fixed CPAP on the basis of APAP titration or being treated with APAP must have close clinical follow-up to determine treatment effectiveness and safety; and (8) a reevaluation and, if necessary, a standard attended CPAP titration should be performed if symptoms do not resolve or the APAP treatment otherwise appears to lack efficacy."

Therapies and Procedures

1. Positive-Pressure Respiration (PEEP)
2. Continuous Positive Airway Pressure
3. Artificial Respiration (Mechanical Ventilation)
4. Mechanical Ventilators (Ventilator)
5. Analgesia